Efficacy of a new collection procedure for preventing bacterial contamination of whole‐blood donations

Bruneau, Cécile; Perez, Paul; Chassaigne, M; Allouch, P.; Audurier, A; Gulian, C.; Janus, G.; Boulard, G.; Micco, Philippe de; Salmi, Louis Rachid; Noël, Luc

doi:10.1046/j.1537-2995.2001.41010074.x

Cited by 104 publications

(101 citation statements)

References 31 publications

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“…A study performed with 22,000 samples of donated blood by the Red Cross in The Netherlands, in which the first 10 ml of donor blood was diverted from the primary bag, showed that 16 of the first 5-ml aliquots were bacterially contaminated while only 2 of the second 5-ml aliquots were positive after culture (19). A second study in France showed that removal of the first 10 ml of donor blood was associated with a significant decrease in bacterial contamination (18,263 collections with 0.39% contamination compared with 7,115 collections with 0.21% contamination; P Ͻ 0.05) (12).…”

Section: Avoidancementioning

confidence: 98%

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Bacterial Contamination of Blood Components

2005

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Blood for transfusion is a potential source of infection by a variety of known and unknown transmissible agents. Over the last 20 years, astounding reductions in the risk of viral infection via allogeneic blood have been achieved. As a result of this success, bacterial contamination of blood products has emerged as the greatest residual source of transfusion-transmitted disease. This paper summarizes the current status of detection, prevention, and elimination of bacteria in blood products for transfusion

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Section: Avoidancementioning

confidence: 98%

“…Such methods are most effective with respect to skin contaminants (12,19). However, it has been said that "one should not be diverted by diversion," since most fatal cases of bacterial contamination involve gram-negative organisms and thus would not minimized by diversion.…”

Section: Avoidancementioning

confidence: 99%

Bacterial Contamination of Blood Components

2005

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“…Several recent studies suggest that the diversion of the initial 15 to 30 mL of whole blood from the main container might be associated with reduced risk of bacterial contamination. [54][55][56] Several blood bag manufacturers have developed plastic software to accommodate such an option. Several countries, including Canada, have recently introduced this intervention to try to reduce the rate of transfusion-associated sepsis.…”

Section: Removal Of First Aliquot Of Donor Bloodmentioning

confidence: 99%

Bacterial Contamination of Blood Components: Risks, Strategies, and Regulation

Hillyer

Josephson²,

Blajchman³

et al. 2003

Hematology

218

210

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Bacterial contamination of transfusion products, especially platelets, is a longstanding problem that has been partially controlled through modern phlebotomy practices, refrigeration of red cells, freezing of plasma and improved materials for transfusion product collection and storage. Bacterial contamination of platelet products has been acknowledged as the most frequent infectious risk from transfusion occurring in approximately 1 of 2,000-3,000 whole-blood derived, random donor platelets, and apheresis-derived, single donor platelets. In the US, bacterial contamination is considered the second most common cause of death overall from transfusion (after clerical errors) with mortality rates ranging from 1:20,000 to 1:85,000 donor exposures. Estimates of severe morbidity and mortality range from 100 to 150 transfused individuals each year.Concern This Joint ASH and AABB Educational Session reviews the risks, testing strategies, and regulatory approaches regarding bacterial contamination of blood components to aid in preparing practitioners of hematology and transfusion medicine in understanding the background and clinical relevance of this clinically important issue and in considering the approaches currently available for its mitigation, as well as their implementation.In this chapter, Drs. Hillyer and Josephson review the background and significance of bacterial contamination, as well as address the definitions, conceptions and limitations of the terms risk, safe and safety. They then describe current transfusion risks including non-infectious serious hazards of transfusion, and current and emerging viral risks. In the body of the text, Dr. Blajchman reviews the prevalence of bacterial contamination in cellular blood components in detail with current references to a variety of important studies. He then describes the signs and symptoms of transfusion-associated sepsis and the sources of the bacterial contamination for cellular blood products including donor bacteremia, and contamination during whole blood collection and of the collection pack. This is followed by strategies to decrease the transfusion-associated morbidity/mortality risk of contaminated cellular blood products 576American Society of Hematology including improving donor skin disinfection, removal of first aliquot of donor blood, pretransfusion detection of bacteria, reducing recipient exposure, and pathogen reduction/inactivation. In the final sections, Drs. Vostal, Epstein and Goodman describe the regulations and regulatory approaches critical to the appropriate implementation of a bacterial contamination screening and limitation program including their and/or the FDA's input on prevention of bacterial contamination, bacterial proliferation, and detection of bacteria in transfusion products. This is followed by a discussion of sampling strategy for detection of bacteria in a transfusion product, as well as the current approval process for bacterial detection devices, trials recommended under "actual clinical use" conditions, pathogen reduction ...

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“…This blood is used for standard laboratory tests. Some authors claim such a practice may reduce the initial amount of bacteria in the blood taken even by 70 -90%, but it does not eliminate the risk for its being contaminated (53,54,55 …”

Section: Lowering the Risk For Contaminating Collected Blood With Donmentioning

confidence: 99%