Efficacy of a New Agonist-Antagonist Protocol Compared To Microdose Flare-up in Poor Responder IVF Patients

Comparison of the ultrashort gonadotropin-releasing hormone agonist-antagonist protocol with microdose flare-up protocol in poor responders: a preliminary study

“…However, in another study from Yarali et al İt was reported that, in terms of the high fertilization rate and the rate of at least one top-quality embryo transferred in the GnRH antagonist/letrozole protocol, compared with the mirodose protocol the GnRH antagonist/ letrozole protocol is an effective protocol that may be used in poor ovarian responders for ICSI (31). Although as in the above studies, several trials investigated the microdose flare and antagonist protocols or antagonist plus letrozole protocol in poor responders, only a limited number of studies in the literature investigated combining the ultrashort GnRH agonist-antagonist protocols in poor responders (17,19,32). The report by Berger et al (19), which is the first report dealing with the AAP protocol, was presented only as a meeting abstract, so no data exists concerning the stimulation characteristics of the control cycles.…”

“…In addition, they did not report any information regarding the patients' previous stimulation protocols. In 2005, Erden et al in their retrospective study, compared the Agonist-Antagonist Protocol and microdose flare-up protocols in poor responder IVF patients (32). They reported that there were higher peak estradiol levels, more mature and fertilized oocytes and higher clinical pregnancy rates in the Agonist-Antagonist Protocol.…”