Efficacy of a mouthwash containing essential oils and curcumin as an adjunct to nonsurgical periodontal therapy among rheumatoid arthritis patients with chronic periodontitis: A randomized controlled trial

Anusha, Divvi; Chaly, Preetha Elizabeth; Junaid, Mohammed; Nijesh, J E; Shivashankar, K. N.; Sivasamy, Shyam

doi:10.4103/ijdr.ijdr_662_17

Cited by 38 publications

(28 citation statements)

References 18 publications

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“…They also investigated epigenetic modifications including chemical alterations of DNA and associated proteins influencing the remodelling of the chromatin and gene malfunctions, which may be related to both periodontitis and RA. The results revealed that MEC as an adjunct to SRP as an effective approach in reducing the disease activity of both RA and chronic periodontitis [73].…”

Section: Plant-derived Essential Oilsmentioning

confidence: 95%

Effects of Essential Oils and Selected Compounds from Lamiaceae Family as Adjutants on the Treatment of Subjects with Periodontitis and Cardiovascular Risk

et al. 2021

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Essential oils from different plant species were found to contain different compounds exhibiting anti-inflammatory effects with the potential to be a valid alternative to conventional chemotherapy that is limited in long-term use due to its serious side effects. Generally, the first mechanism by which an organism counteracts injurious stimuli is inflammation, which is considered a part of the innate immune system. Periodontitis is an infectious and inflammatory disease caused by a dysbiosis in the subgingival microbiome that triggers an exacerbated immune response of the host. The immune–inflammatory component leads to the destruction of gingival and alveolar bone tissue. The main anti-inflammation strategies negatively modulate the inflammatory pathways and the involvement of inflammatory mediators by interfering with the gene’s expression or on the activity of some enzymes and so affecting the release of proinflammatory cytokines. These effects are a possible target from an effective and safe approach, suing plant-derived anti-inflammatory agents. The aim of the present review is to summarize the current evidence about the effects of essentials oils from derived from plants of the Lamiaceae family as complementary agents for the treatment of subjects with periodontitis and their possible effect on the cardiovascular risk of these patients.

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Section: Plant-derived Essential Oilsmentioning

confidence: 95%

Effects of Essential Oils and Selected Compounds from Lamiaceae Family as Adjutants on the Treatment of Subjects with Periodontitis and Cardiovascular Risk

et al. 2021

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“…The chemical name of curcumin is diferuloylmethane (C21H20O6) and its structure contain two aryl rings with ortho methoxy group linked in beta diketone moiety [3]. Literature survey revealed that curcumin has various therapeutic effects like anti-inflammatory [4], anti-oxidant [5], anti-proliferative [6], anti-atherosclerosis [7], anti-Amyloid [8] and anti-arthritis [9]. After several therapeutic effects, use of curcumin is limited because of low bioavailability of curcumin which may be due to rapid metabolism, low absorption in intestine and its hydrophobic nature [10].…”

Section: Introductionmentioning

confidence: 99%

Method Development and Validation of UV Spectrophotometric Method for the Quantitative Estimation of Curcumin in Simulated Nasal Fluid

Sharma

Bhatt

et al. 2020

Drug Res (Stuttg)

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Background Curcumin is a polyphenolic compound with numerous therapeutic activities. There is no validated method available for the quantitative estimation of curcumin in simulated nasal fluid. Objective The aim of present investigation was to develop a simple and precise UV visible spectrophotometric method for estimation of pure form of curcumin in simulated nasal fluid. Method Suitable solvent system was selected by estimation of curcumin at UV maxima of 421nm in simulated nasal fluid with two surfactants (tween 80 and sodium lauryl sulphate). The double beam UV visible spectrophotometer was used for measurement of absorption. The selected solvent system was further validated according to guidelines of international conference on harmonization (ICH), the analytical parameter like linearity, precision and accuracy etc. were studied. Results Simulated nasal fluid with tween 80 at 1% concentration satisfied all the conditions relative to Peak quality at the stated wavelength. In developed method, curcumin was found to be linear over selected concentration range of 5 to 60µg/ml with a correlation coefficient of 0.998. The accuracy was found to be in range of 99.51 –100.223%.The precision was found to be less than 2 in terms of % RSD. The LOD & LOQ were 0.3657 & 1.109 respectively. Conclusion The proposed method was found to be simple, sensitive and precise. The most important this method can be used for routine quality control analysis of curcumin with accuracy.

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“…In our search of the PubMed search engine, we found four randomized clinical trials ( Table 3 ) of essential oil therapy. Out of these four trials, aromatherapy with essential oils was used in two studies, whereas oral or gargling administrations were used in the other two trials [ 354 , 355 , 356 , 357 ]. A recent systematic review reported that essential oils have been used to treat RA, mainly with a small number of subjects for a short duration of observation (2–12 weeks), and mostly with women (60–100%) [ 358 ].…”

Section: Obesity and Arthritis Managementmentioning

confidence: 99%

The Role of Medicinal and Aromatic Plants against Obesity and Arthritis: A Review

et al. 2022

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Obesity is a significant health concern, as it causes a massive cascade of chronic inflammations and multiple morbidities. Rheumatoid arthritis and osteoarthritis are chronic inflammatory conditions and often manifest as comorbidities of obesity. Adipose tissues serve as a reservoir of energy as well as releasing several inflammatory cytokines (including IL-6, IFN-γ, and TNF-α) that stimulate low-grade chronic inflammatory conditions such as rheumatoid arthritis, osteoarthritis, diabetes, hypertension, cardiovascular disorders, fatty liver disease, oxidative stress, and chronic kidney diseases. Dietary intake, low physical activity, unhealthy lifestyle, smoking, alcohol consumption, and genetic and environmental factors can influence obesity and arthritis. Current arthritis management using modern medicines produces various adverse reactions. Medicinal plants have been a significant part of traditional medicine, and various plants and phytochemicals have shown effectiveness against arthritis and obesity; however, scientifically, this traditional plant-based treatment option needs validation through proper clinical trials and toxicity tests. In addition, essential oils obtained from aromatic plants are being widely used as for complementary therapy (e.g., aromatherapy, smelling, spicing, and consumption with food) against arthritis and obesity; scientific evidence is necessary to support their effectiveness. This review is an attempt to understand the pathophysiological connections between obesity and arthritis, and describes treatment options derived from medicinal, spice, and aromatic plants.

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Efficacy of a mouthwash containing essential oils and curcumin as an adjunct to nonsurgical periodontal therapy among rheumatoid arthritis patients with chronic periodontitis: A randomized controlled trial

Cited by 38 publications

References 18 publications

Effects of Essential Oils and Selected Compounds from Lamiaceae Family as Adjutants on the Treatment of Subjects with Periodontitis and Cardiovascular Risk

Effects of Essential Oils and Selected Compounds from Lamiaceae Family as Adjutants on the Treatment of Subjects with Periodontitis and Cardiovascular Risk

Method Development and Validation of UV Spectrophotometric Method for the Quantitative Estimation of Curcumin in Simulated Nasal Fluid

The Role of Medicinal and Aromatic Plants against Obesity and Arthritis: A Review

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