Efficacy of a morantel–abamectin combination for the treatment of resistant ascarids in foals

Wilkes, Edwina; McConaghy, F F; Thompson, Renee L.; Dawson, K. L.; Sangster, Nicholas C.; Hughes, Kristopher

doi:10.1111/avj.12559

Cited by 19 publications

(20 citation statements)

References 20 publications

(63 reference statements)

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“…For Parascaris , ML drugs, if active against larval stages, will reduce refugia and may increase selection pressure for AR . In the current study, MLs in interval treatment programmes were extensively used by respondents for foals which may be associated with the development of resistance to ivermectin in Parascaris , which has been described recently to occur on Australian stud farms …”

Section: Discussionmentioning

confidence: 83%

A questionnaire study of parasite control in Thoroughbred and Standardbred horses in Australia

Wilkes

Heller

Raidal

et al. 2020

Equine Veterinary Journal

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Background Information regarding parasite control practices currently used on Thoroughbred and Standardbred studs in Australia is lacking. Anthelmintic resistance (AR) is a global problem which has implications for equine health and welfare. Objectives To identify parasite control practices currently used on horse studs in Australia and investigate the frequency of use of management factors that have been associated with the likelihood of promoting or delaying AR. Study design Questionnaire study of equine parasite control on Thoroughbred and Standardbred studs in Australia. Methods An online questionnaire was emailed to 300 studs in Australia. Information obtained included property details, grazing management, anthelmintic use, non‐chemotherapeutic parasite control practices, use of faecal egg counts (FECs) and perceptions of AR. Results Seventy‐five completed questionnaires were received (25% response rate). Macrocyclic lactones (MLs) were the most commonly administered anthelmintics in mares and foals and less than 5% of respondents used targeted treatment regimens. The implementation of pasture hygiene practices was variable. The majority of respondents (97%) considered AR to be important; however, few respondents were aware of the use of FEC reduction tests for monitoring of drug efficacy. Main limitations The potential for nonresponse bias was the main limitation of this study. Conclusions Parasite control strategies on Australian stud farms remain over‐reliant on anthelmintic use. The frequent use of MLs is of concern for the increased selection pressure for AR. There is a lack of awareness of the importance of non‐chemotherapeutic strategies in integrated approaches to parasite control aimed at delaying the development of AR. This study highlights the need for greater veterinary involvement in the implementation of more sustainable parasite control practices with greater emphasis placed on surveillance through FEC testing.

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Section: Discussionmentioning

confidence: 83%

A questionnaire study of parasite control in Thoroughbred and Standardbred horses in Australia

Wilkes

Heller

Raidal

et al. 2020

Equine Veterinary Journal

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“…However, resistance of Parascaris spp. has been reported to an abamectin/morantel combination where abamectin alone exhibited poor efficacy [18, 24, 79, 80]. A combination of morantel, oxibendazole and dichlorvos was shown to be effective against cyathostomins, strongylins as well as a benzimidazole-resistant P. equorum [18].…”

Section: Control Of Gins In Horsesmentioning

confidence: 99%

“…However, the majority of equine owners/managers in Australia usually follow a regular treatment interval of 6–8 weeks without any estimation of faecal egg counts (FECs) or consideration of seasonal variation [19]. The intensive use of anthelmintics has driven in the emergence of GIN populations resistant to all major classes of anthelmintics used in Australia, including benzimidazoles, macrocyclic lactones and tetrahydropyrimidines [12, 18, 20–24]. Thus, a national survey of the prevalence of anthelmintic resistance (AR) in Australian horses is required for the effective control and management of equine nematodes.…”

Section: Introductionmentioning

confidence: 99%

Systematic review of gastrointestinal nematodes of horses from Australia

et al. 2019

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Background Equine gastrointestinal nematodes (GINs) have been the subject of intermittent studies in Australia over the past few decades. However, comprehensive information on the epidemiology of equine GINs, the efficacy of available anthelmintic drugs and the prevalence of anthelmintic resistance (AR) in Australasia is lacking. Herein, we have systematically reviewed existing knowledge on the horse GINs recorded in Australia, and main aspects of their pathogeneses, epidemiology, diagnoses, treatment and control. Methods Six electronic databases were searched for publications on GINs of Australian horses that met our inclusion criteria for the systematic review. Subsets of publications were subjected to review epidemiology, diagnoses, pathogeneses, treatment and control of GINs of horses from Australia. Results A total of 51 articles published between 1950 to 2018 were included. The main GINs reported in Australian horses were cyathostomins (at least 28 species), Draschia megastoma , Habronema muscae , H. majus , Oxyuris equi , Parascaris equorum , Strongyloides westeri and Trichostrongylus axei across different climatic regions of Queensland, New South Wales, Victoria, and Western Australia. Nematodes are diagnosed based on the traditional McMaster egg counting technique, though molecular markers to characterise common GINs of equines were characterised in 1990s. The use of anthelmintic drugs remains the most widely-used strategy for controlling equine GIN parasites in Australia; however, the threshold of faecal egg count that should trigger treatment in horses, remains controversial. Furthermore, anthelmintic resistance within GIN population of horses is becoming a common problem in Australia. Conclusions Although GINs infecting Australian horses have been the subject of occasional studies over the past few decades, the effective control of GIN infections is hampered by a generalised lack of knowledge in various disciplines of equine parasitology. Therefore, coordinated and focused research is required to fill our knowledge gaps in these areas to maximise equine health and minimise economic losses associated with the parasitic infections in Australia. Electronic supplementary material The online version of this article (10.1186/s13071-019-3445-4) contains supplementary material, which is available to authorized users.

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“…This month's equine study used combination anthelmintics to effectively treat foals with macrocylic lactone (ML)‐resistant Parascaris species . As traditional anthelmintics are becoming less useful in controlling Parascaris species, because of increasing anthelmintic resistance (AR), a strategy used in ruminant grazing to reduce the rate of AR is combining anthelmintics with the same spectrum of activity but different mechanisms of action.…”

mentioning

confidence: 99%

“…This month's equine study used combination anthelmintics to effectively treat foals with macrocylic lactone (ML)-resistant Parascaris species. 7 As traditional anthelmintics are becoming less…”

mentioning

confidence: 99%

In this issue – March 2017

Jackson¹

2017

Aust Veterinary J

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Efficacy of a morantel–abamectin combination for the treatment of resistant ascarids in foals

Abstract: On all properties, resistance to ivermectin and abamectin was present and the Parascaris FECR in foals administered the morantel-abamectin combination was > 99%, indicating that this combination effectively controlled ML-resistant parasites.

Cited by 19 publications

References 20 publications

A questionnaire study of parasite control in Thoroughbred and Standardbred horses in Australia

A questionnaire study of parasite control in Thoroughbred and Standardbred horses in Australia

Systematic review of gastrointestinal nematodes of horses from Australia

In this issue – March 2017

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