Efficacy of a mini version of the frameless GyneFix intrauterine system (IUS) with effective copper surface area of 200 mm2

Wildemeersch, Dirk; Cao, Xiaoming; Zhang, Wenhao; Xuan, Zhao; Lin, Nong; Wang, Limei; Li, Chunhua; Song, Lijuan; Zhang, Weijia; Delbarge, W.

doi:10.1016/s0010-7824(02)00345-1

Cited by 5 publications

(9 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These include a mini-GyneFix (the GF200 ® ) with a copper surface area of just 200 mm 2 , and GynePlant ® (a frameless device containing both copper and levonorgestrel). 20,21 Conclusions Although this study does not show the GyneFix to be superior to the Gyne-T380S for ease of insertion or discomfort, it does suggest that pain is less subsequent to insertion, accounting for higher continuation rates. The high overall continuation rate of both emergency IUDs at 6 weeks and the low morbidity seen in this study, plus its higher efficacy over oral EC, should encourage us to offer IUD insertion more often where unprotected intercourse has occurred.…”

Section: Description Of Pain Insertionmentioning

confidence: 57%

Randomised controlled trial assessing the acceptability of GyneFix® versus Gyne-T380S® for emergency contraception

D'Souza¹,

Masters²,

Bounds³

et al. 2003

j fam plann reprod health care

View full text Add to dashboard Cite

show abstract

Section: Description Of Pain Insertionmentioning

confidence: 57%

Randomised controlled trial assessing the acceptability of GyneFix® versus Gyne-T380S® for emergency contraception

D'Souza¹,

Masters²,

Bounds³

et al. 2003

j fam plann reprod health care

View full text Add to dashboard Cite

show abstract

“…The high initial and ongoing effectiveness of the ‘anchored device’ is attributed to its constant release of spermicidal copper ions in the upper part of the uterine cavity. This may explain why clinical trials with the mini IUS suggest a similar efficacy as the standard IUS 13 …”

Section: Efficacymentioning

confidence: 94%

“… High efficacy, 6–9,11 , 13,17–21 Efficacy does not decrease with time, 6,7 , 9,11 Low expulsion rate, 6–9,11 , 17–21 Reduced bleeding, 13 Reduced pain complaints, 7,8 , 11,13 , 17,22 Long duration of action 9 …”

Section: Potential Advantages Of the Frameless Copper‐releasing Ius Omentioning

confidence: 99%

“…The amount of excess bleeding is less (50–60 mL) with the smaller copper devices such as the copper T series. Clinical trials suggest that both the mini and standard GyneFix reduce the incidence of heavy blood loss due to the small size of the foreign body, however, comparative studies, which could actually quantify the blood loss have not been published 11,13 …”

Section: Side‐effectsmentioning

confidence: 99%

“…This could be particularly the case with the frameless IUS, which guarantees release of copper in the fundal area of the uterus, if the IUS is properly attached to the uterine wall. Clinical studies with the mini IUS do not suggest a reduced protection against ectopic pregnancy caused by the significantly reduced copper surface area 13 . It is important to note that an estimated 30–40% of the copper surface of IUDs is ineffective as no copper release occurs from the copper wire in contact with the plastic frame 45,46 .…”

Section: Ectopic Pregnanciesmentioning

confidence: 99%

See 2 more Smart Citations

The ‘frameless’ intrauterine system for long‐term, reversible contraception: A review of 15 years of clinical experience

Wildemeersch

Batar

Affandi

et al. 2003

J of Obstet and Gynaecol

Self Cite

View full text Add to dashboard Cite

Young nulliparous/nulligravid and parous women may significantly benefit from the advantages the 'frameless' IUS, which could be strategically important to help in reducing the increasing number of unintended pregnancies and induced abortions worldwide. Furthermore, the 'frameless' IUS has been shown to be highly effective for emergency contraception and for immediate postabortal insertion. The long lifespan of the IUS could constitute a cost-effective reversible alternative to irreversible female sterilization.

show abstract

Comparison of the release behaviors of cupric ions from metallic copper and a novel composite in simulated body fluid

Suo

Huang

et al. 2007

J Biomed Mater Res

View full text Add to dashboard Cite

The copper-containing intrauterine devices (Cu-IUDs) are being increasingly used worldwide as an effective contraceptive for family planning. To avoid abnormal bleeding, pain, and partial and complete expulsion which are associated with the burst release of copper during the first few days, a novel crosslinked composite based on poly(vinyl alcohol) that contained cupric ions, but not metallic copper, was synthesized. It is hypothesized that the burst release of cupric ions could be avoided and the utility of the cupric ions could be improved by this novel composite. To evaluate these effects of the composite, the corrosion products and the release rate of cupric ions after soaking in simulated body fluid (SBF) for different time spans were studied by environmental scanning electron microscopy, X-ray energy dispersive spectroscopy, X-ray diffraction, and atomic absorption spectrophotometer. In the first week, the release amount of cupric ions in the composite was 0.486 microg/mm(2). In the fifth week, it decreased to 0.0278 microg/mm(2). But for metallic copper, these were 5.93 microg/mm(2) and 0.041 microg/mm(2), respectively. No significant change on time-dependence was found for the release rates of cupric ions in the composite compared with that of metallic copper. Moreover, no other new elements, such as P, Cl, and Ca, appeared on the surface of the composite, and no Cu2O was formed after immersing in SBF for 90 days. All of these results suggested that burst release of cupric ions could be avoided and the effective utility of copper could be improved in this composite. In view of the earlier results, this novel copper-containing composite might serve as a potential substitute for conventional materials of IUDs in the future.

show abstract

Efficacy of a mini version of the frameless GyneFix intrauterine system (IUS) with effective copper surface area of 200 mm2

Cited by 5 publications

References 3 publications

Randomised controlled trial assessing the acceptability of GyneFix<SUP>®</SUP> versus Gyne-T380S<SUP>®</SUP> for emergency contraception

Randomised controlled trial assessing the acceptability of GyneFix<SUP>®</SUP> versus Gyne-T380S<SUP>®</SUP> for emergency contraception

The ‘frameless’ intrauterine system for long‐term, reversible contraception: A review of 15 years of clinical experience

Comparison of the release behaviors of cupric ions from metallic copper and a novel composite in simulated body fluid

Contact Info

Product

Resources

About