Efficacy of a long-acting formulation of ceftiofur crystalline-free acid for the treatment of naturally occurring infectious bovine keratoconjunctivitis

Dueger, Erica; George, Lisle W.; Angelos, John A.; Tankersley, Natalie S.; Luiz, Kelsie M.; Meyer, J; Portis, Ellen; Lucas, Merlyn J.

doi:10.2460/ajvr.2004.65.1185

Cited by 27 publications

(26 citation statements)

References 6 publications

(3 reference statements)

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“…The pinna site was chosen due to the reduced risk for tissue residue and the lower potential for injection‐site trimming at slaughter. Concentrations of ceftiofur metabolites in plasma have been shown to remain well above published M bovis modal MIC values for more than 7 days when administered via this particular route 12,32,33 . A single dose of CCFA (6.6 mg of ceftiofur equivalents/kg, SC) proved effective in the treatment of IBK in beef calves, resulting in shorter mean healing times, smaller corneal ulcer surface areas, amelioration of ocular discharge and photophobia, and a 50% increase in the percentage of calves healed by day 14 32 .…”

Section: Systemic Treatmentmentioning

confidence: 71%

Infectious bovine keratoconjunctivitis antimicrobial therapy

2007

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Infectious bovine keratoconjunctivitis (IBK) is one of the most common diseases of cattle and is of major economic importance. If the primary aetiological agent, Moraxella bovis, is successfully eliminated from ocular tissues corneal ulcers heal at a constant rate. If treatment is unsuccessful ulcer reoccurrence may follow initial healing. Appropriate antimicrobial selection requires knowledge of antimicrobial sensitivities and distribution in ocular tissues and tears. Drugs may be delivered to the eye in several ways: subconjunctival injection, topical application and systemic administration. While therapeutic efficacy is affected by the frequency and mode of drug delivery, variations between intensive and extensive enterprises dictate the practical method of antimicrobial delivery. Specific recommendations for antimicrobial therapies targeting Australian IBK outbreaks are dependent upon antimicrobial pharmacokinetics, drug regulations and associated costs.

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Section: Systemic Treatmentmentioning

confidence: 71%

Infectious bovine keratoconjunctivitis antimicrobial therapy

2007

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“…50 In that study a control group of calves were administered vehicle alone (control group). This treatment resulted in a 4 fold increased odds of corneal ulcer healing by 14 days as compared to control group calves and results supported that CCFA was effective against naturally occurring IBK.…”

Section: Parenteral Ceftiofurmentioning

confidence: 99%

Infectious Bovine Keratoconjunctivitis (Pinkeye)

Angelos

2015

Veterinary Clinics of North America: Food Animal Practice

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Key Points• Effective treatment of pinkeye requires accurate diagnosis• Antibiotic treatment can the shorten healing time• Multiple routes of antibiotic delivery can be effective• Efforts to develop herd preventive strategies must involve considerations of risk factors Video of classical signs of Infectious bovine keratoconjunctivitis accompanies this article. AbstractAs with many livestock diseases, the most successful efforts to control (Infectious bovine keratoconjunctivitis) IBK include multiple facets of disease control including the host, the environment, herd management, and ongoing surveillance even after the immediate crisis has Discussions of IBK control programs with producers should take into consideration all aspects of the disease including the host immune response and reduction of potential risk factors. Outline Key PointsAbstract Introduction

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“…In one study, bacteria that were cultured from IBK-associated corneal ulcers were identified as Gram negative cocci in ∼46% of ulcers, while only ∼21% of ulcers were M. bovis positive (Dueger et al 2004). Gram negative cocci from that study were subsequently identified as M. bovoculi (Angelos et al 2007c).…”

Section: Introductionmentioning

confidence: 99%

Recombinant Moraxella bovoculi cytotoxin-ISCOM matrix adjuvanted vaccine to prevent naturally occurring infectious bovine keratoconjunctivitis

et al. 2010

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A randomized, blinded, controlled field trial was conducted during summer 2006 in a northern California, USA, herd of beef cattle to evaluate the efficacy of a recombinant Moraxella bovoculi cytotoxin subunit vaccine to prevent naturally occurring infectious bovine keratoconjunctivitis (IBK; pinkeye). A convenience sample comprised of 127 steers were administered a subcutaneous dose of either adjuvant alone (ISCOM matrices; control group) or recombinant M. bovoculi cytotoxin carboxy terminus adjuvanted with ISCOM matrices (MbvA group) and were boostered 21 days later. The steers were examined once weekly for 15 weeks for evidence of IBK. No significant difference in the cumulative proportion of corneal ulcerations was detected between groups. Compared to the control calves, the MbvA vaccinates had significantly higher increases in serum neutralizing titers to M. bovoculi hemolysin between week 0 and week 6. The prevalence of M. bovis isolations was higher from ulcerated eyes of calves vaccinated with MbvA as compared to control calves. Vaccination of calves against the carboxy terminus of M. bovoculi RTX toxin resulted in significant increases in serum hemolysin neutralizing titers and may modulate organism type cultured from ulcerated eyes of calves in herds where both M. bovis and M. bovoculi exist. Use of M. bovoculi antigens alone in vaccines to prevent IBK may not be beneficial in herds where IBK is associated with both M. bovoculi and M. bovis.

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Efficacy of a long-acting formulation of ceftiofur crystalline-free acid for the treatment of naturally occurring infectious bovine keratoconjunctivitis

Abstract: A single dose of CCFA administered into the posterior aspect of a pinna had a positive treatment effect against naturally occurring IBK in calves with corneal ulcerations.

Cited by 27 publications

References 6 publications

Infectious bovine keratoconjunctivitis antimicrobial therapy

Infectious bovine keratoconjunctivitis antimicrobial therapy

Infectious Bovine Keratoconjunctivitis (Pinkeye)

Recombinant Moraxella bovoculi cytotoxin-ISCOM matrix adjuvanted vaccine to prevent naturally occurring infectious bovine keratoconjunctivitis

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