Efficacy of a local-drug delivery gel containing extracts of Quercus brantii and Coriandrum sativum as an adjunct to scaling and root planing in moderate chronic periodontitis patients

Abstract

Objective:Recent advances in the field of alternative medicine introduced various herbal products for the treatment of periodontitis. The purpose of this study was to evaluate the effects of combined extracts from Quercus brantii and Coriandrum sativum on periodontal indices in adult periodontitis patients.Methods:In this randomized, double-blinded clinical trial, performed in Isfahan Dental School in 2012, a new herbal medicament containing combined extracts from Q. brantii and C. sativum was formulated in the gel form for subgingival application. Following scaling and root planing (SRP), both herbal and placebo gels were delivered at the experimental and control sites, respectively. Periodontal pocket depth, clinical attachment level, papilla bleeding index, and plaque index were measured at baseline, 1 month and 3 months later. Both intra-and inter-groups changes were registered. The obtained data were analyzed by SPSS software, using repeated measure analysis of variance, paired t-test, Mann-Whitney, Friedman, and Wilcoxon tests. Differences with P < 0.05 were considered to be significant.Findings:Both groups indicated statistically significant improvements in the periodontal indices (P < 0.05), but there were no significant differences between two study groups with this regard.Conclusion:The herbal gel does not have considerable advantages over SRP alone as an adjunct in periodontal treatment.

Effect of an herbal mouthwash on periodontal indices in patients with plaque-induced gingivitis: A cross-over clinical trial

“…The sample size was estimated at 25 participants in each group based on the study of Yaghini et al, SD: 0.46, 0.63, and at least one unit of expected difference between the two groups. 9 Fifty volunteers 20‒30 years of age were selected from dental students in Shahid Beheshti School of Dentistry by a single trained periodontist (M. TA.).…”

“… 7 , 8 In addition, bacterial accumulation in other areas of the oral cavity, such as the tongue, oral mucosa, and tonsils, can contribute to re-infection. 9 , 10 Antimicrobial mouthwashes may reduce bacterial adhesion to the tooth surfaces or the growth and division of microorganisms. 11 …”

“…Considering the available evidence on anti-inflammatory, antibacterial, antioxidant, antifungal, and antiviral effects of the herbal mouthwash constituents. 7 , 9 , 14 , 16 - 21 this study aimed to assess the effect of this mouthwash as an adjunct to the non-surgical treatment of plaque-induced gingivitis.…”

Phyllanthus emblica fruits: a polyphenol-rich fruit with potential benefits for oral management

“…Recently, natural products have shown many positive effects in the adjuvant therapy of periodontitis, 137–140 with the majority of them possessing exceptional anti-inflammatory, antioxidant, and bacteriostatic properties. Clinical studies 32 have shown that the subgingival delivery of 10% PEF gel as an adjunct to SRP in the treatment of chronic periodontitis can significantly improve the periodontal parameters of patients more effectively than SRP alone, including the plaque index (PI), gingival index (GI), modified sulcus bleeding index (mSBI), probing pocket dept (PPD), and clinical attachment level (CAL).…”

Potential applications of medicinal herbs and phytochemicals in oral and dental health: Status quo and future perspectives

“…In the research, a 4% concentration of Ocimum sanctum extract was shown to be the most efficient in combating oral bacterial microflora. In Iran, a Coriandrum sativum and Quercus brantii oral gel were recently explored (Yaghini et al, 2014). The clinical experiment used a combination of Coriandrum sativum and Quercus brantii because both plants contained tannins that may restrict bacterial activity in the periodontium.…”