Efficacy of a Comfrey root extract ointment in comparison to a Diclo-fenac gel in the treatment of ankle distortions: Results of an observer-blind, randomized, multicenter study

Predel, Hans‐Georg; Giannetti, Bruno; Koll, Robert; Bulitta, Michael; Staiger, Christiane

doi:10.1016/j.phymed.2005.06.001

Cited by 45 publications

(37 citation statements)

References 17 publications

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“…In comparing an NSAID gel with a comfrey extract cream, 2 separate studies found that the comfrey cream was superior in reducing edema and pain and in improving movement to the NSAID cream. 21,22 Again, no adverse effects were reported in either study. In reference to bone, when comfrey was administered orally, radiographic bone density has been shown to increase around titanium implants.…”

Section: Introductionmentioning

confidence: 79%

“…Botanicals such as stinging nettle, 39 devil's claw, turmeric, and ginger 40 have yielded positive results, whereas avocado soybean fraction, rose hip, and seed powder showed moderate positive results and Boswellia serrata gum resin registered poor outcomes. 41 Previous studies using comfrey have all suggested that the herb is effective in treating edema 15,22 and pain associated with OA. Previous studies have found a 46% 42,43 and a 54.7% 24 reduction in OA knee pain following a regimen of comfrey cream use compared with a 10.7% improvement in a placebo group.…”

Section: Discussionmentioning

confidence: 99%

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Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials

Smith

Jacobson

2011

Journal of Chiropractic Medicine

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Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials The purpose of this study was to determine the effect of 2 concentrations of topical, comfrey-based botanical creams containing a blend of tannic acid and eucalyptus to a eucalyptus reference cream on pain, stiffness, and physical functioning in those with primary osteoarthritis of the knee. Methods: Forty-three male and female subjects (45-83 years old) with diagnosed primary osteoarthritis of the knee who met the inclusion criteria were entered into the study. The subjects were randomly assigned to 1 of 3 treatment groups: 10% or 20% comfrey root extract (Symphytum officinale L.) or a placebo cream. Outcomes of pain, stiffness, and functioning were done on the Western Ontario and MacMaster Universities Osteoarthritis Index. Participants applied the cream 3× a day for 6 weeks and were evaluated every 2 weeks during the treatment. Results: Repeated-measures analyses of variance yielded significant differences in all of the Western Ontario and MacMaster Universities Osteoarthritis Index categories (pain P b .01, stiffness P b .01, daily function P b .01), confirming that the 10% and 20% comfrey-based creams were superior to the reference cream. The active groups each had 2 participants who had temporary and minor adverse reactions of skin rash and itching, which were rapidly resolved by modifying applications. Conclusion: Both active topical comfrey formulations were effective in relieving pain and stiffness and in improving physical functioning and were superior to placebo in those with primary osteoarthritis of the knee without serious adverse effects.

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Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials

Smith

Jacobson

2011

Journal of Chiropractic Medicine

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“…Studies are summarised in Tables 1 and 2 for efficacy and adverse events, respectively. All studies evaluated developing or established commercial comfrey creams; eight evaluated Kytta-Salbe ® (Merck Selbstmedikation GmbH, Darmstadt; S. officinale fresh root and rosemary oil), 41,42,49,51,52,56,62 one S. officinale (part not specified), eucalyptus oil and tannic acid (4Jointz ® ; Arthritis Relief Plus Ltd, Brisbane), 47 one including various S. officinale preparations, 57 eleven Traumaplant ® (Harras Pharma Curarina GmbH, München; S. x uplandicum fresh leaf) [43][44][45][46][53][54][55]59,[63][64][65] and five combined products including Symphytum species (plant part unknown) with other herbal extracts including mistletoe (Syviman ® ; Müller Göppingen, Wegenerstr), 48 walnut (Phytoskin ® ; Vita-Cos-Med KlettLoch GmbH, Eisenberg) 66 and calendula, sage and yarrow (Plantoderm ® 50,58 Zdravlje-Actavis Pharmaceutical Company, Leskovac; and Antiacne ® 61 Fontis Ltd., Podgorica). 1 No clinical trials were located for S. asperum.…”

Section: Resultsmentioning

confidence: 99%

A critical scoping review of external uses of comfrey (Symphytum spp.)

Frost

MacPherson

O’Meara

2013

Complementary Therapies in Medicine

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“…The pain response to the pressure on the injured area, the swollen joint circumference, the individual spontaneous pain in resting, the frequency of using the rescue medication (an anti-inflammatory) as well as the general efficacy and tolerability were measured. It has been shown that the comfrey gel is slightly superior to the diclofenac gel [38].…”

Section: Symphytum Officinale (Comfrey)mentioning

confidence: 99%

Medicinal herbs as possible sources of anti-inflammatory products

Corciovă¹,

Matei²,

Ivănescu³

2017

Balneo

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Plants constitute an inexhaustible source of bioactive compounds that can be valuable for research in the chemistry field of antiinflammatory compounds. This review describes several plants from international and national flora that have been shown to have anti-inflammatory activity in various clinical trials. The paper includes: general aspects regarding the vegetal source, compounds responsible for anti-inflammatory activity, mechanism of action and clinical trials carried out with extracts or products containing standardized extracts.

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Efficacy of a Comfrey root extract ointment in comparison to a Diclo-fenac gel in the treatment of ankle distortions: Results of an observer-blind, randomized, multicenter study

Cited by 45 publications

References 17 publications

Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials

Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials

A critical scoping review of external uses of comfrey (Symphytum spp.)

Medicinal herbs as possible sources of anti-inflammatory products

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