At present, the conventional line loss location prediction method mainly adopts the way of stratified location analysis to realize the line loss prediction by calculating the line loss value in layers, but there is a problem of low prediction accuracy. In this regard, a feature vector-based prediction model is proposed. The similarity of line loss sections of distribution networks is calculated, and the actual situation of theoretical line loss and communication line loss is discussed by situation to construct the line loss prediction model. The experimental results show that the output of the proposed prediction model has a low root-mean-square error and has a more desirable prediction effect.