Efficacy of a 28-Day Oral Cyanocobalamin Supplementation on Vitamin B Status in Spanish Institutionalized Elderly

Albers, Ulrike; Pedrero‐Chamizo, Raquel; Meléndez, Agustín; Pietrzik, Klaus; Castillo, Manuel J.; González‐Gross, Marcela

doi:10.1024/0300-9831/a000099

Cited by 6 publications

(5 citation statements)

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“…A study by Sanchez et al showed that a daily dose of 1.4 ug of vitamin B 12 was not sufficient to improve vitamin B 12 status [30]. Supplementation with higher doses of vitamin B 12 ( > 500 ug/day) have proven effective in Latino populations residing in USA [34] and institutionalized Spanish elderly increased significantly from 308.4 pmol/L to 558.3 pmol/L (p < 0.001) [35]. Also, Favrat et al showed that oral vitamin B 12 treatment normalized the metabolic markers [4].…”

Section: Discussionmentioning

confidence: 99%

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

Aparicio‐Ugarriza¹,

Palacios²,

Alder

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

105

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Vitamin B 12 deficit is one of the most common vitamin deficiencies. However, there is no consensus on the cut-off points for vitamin B 12 and its co-markers, such as folate, holotranscobalamin, methylmalonic acid and homocysteine. In order to establish the state of the art about cut-off points used to determine vitamin B 12 deficiency in the last decades, the database MEDLINE was used for searching studies published in adults between December 1992 and May 2014 (69 articles), using search terms like 'vitamin B 12 ', 'cobalamin', 'cut-off', 'deficiency' alone or in combinations. Broad ranges of cut-off points for vitamin B 12 and its biomarkers were identified: vitamin B 12 ranged between 100 pmol/L and 350 pmol/L, holotranscobalamin 20-50 pmol/L, methylmalonic acid 0.210-0.470 μmol/L, homocysteine 10-21.6 μmol/L, serum folate 3.7-15.9 nmol/L and red blood cell 124-397 nmol/L. For the majority of studies, the potential influence of age, analytical methods, gender and fortified food consumption was not taken in account when choosing cut-off values. This could explain the discrepancies between studies on vitamin B 12 and folate deficiency prevalences. We conclude that there is inconsistency in the literature regarding vitamin B 12 cut-offs. It would be necessary to establish different reference cut-offs according to age, considering the analytical methods used.

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Section: Discussionmentioning

confidence: 99%

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

Aparicio‐Ugarriza¹,

Palacios²,

Alder

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

105

View full text Add to dashboard Cite

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“…There is a new trend to give oral and nasal preparations, and preliminary data suggest that they could be just as effective. [37][38][39] Although the possibility of erratic absorption needs to be considered, 40 oral and nasal routes could play a role in medical treatment after correction to normal levels, especially in those who need lifelong treatment. Care should be taken in the replacement of folate in people with a concomitant vitamin B 12 deficiency because the administration of folate without replacement of vitamin B 12 can worsen neurological sequelae.…”

Section: Long Answermentioning

confidence: 99%

A woman with macrocytic anaemia and confusion

Sugrue

Egan

O’Regan

2014

BMJ

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An 82 year old woman with a history of type 2 diabetes presented with unsteady gait and confusion of two months' duration. Her diabetes was controlled by metformin (500 mg, three times a day) and she had no other comorbidities. She was a non-smoker and did not drink alcohol. Dietary history showed an adequate intake of meat, vegetables, and calories.On examination, her vital signs were stable. She was disorientated in time but not in person or place. Cranial nerve examination was normal but examination of the peripheral nervous system showed ataxia and impaired proprioception of the lower limbs bilaterally. The rest of her examination was normal. Her score on the mini-mental state examination at presentation was 18 out of 30.Correspondence to: A Sugrue

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“…It is thought to be due to either alteration in small bowel motility, which stimulates small bowel bacterial overgrowth and subsequent vitamin B12 deficiency, or by directly decreasing vitamin B12 absorption process. [10][11] Peripheral neuropathy is caused by both diabetes mellitus and vitamin B12 deficiency which may produce overlapping clinical pictures. However, non-diabetic neuropathies may be present in patients with diabetes and may be treatable with therapeutic vitamin B12 or vitamin B complex mixtures containing B12 supplementation. )…”

Section: Introductionmentioning

confidence: 99%

Vitamin B12 Status in Long-Term Metformin Treated Type 2 Diabetes Mellitus Patients

Rahul

Ahmed²,

Rahman

et al. 2022

Bangla J Med

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Background: The association between long-term use of metformin and low vitamin B12 levels in patients with type 2 diabetes mellitus (T2DM) has been proven. However, the prevalence among metformin induced vitamin B12 deficiency in T2DM patients showed considerable variations among the studies. The potential of deficiency to cause new onset or worse preexisting peripheral neuropathy in T2DM patients has been investigated with conflicting results.The objective of this study is to determine the frequency of vitamin B12 deficiency among patients with T2DM patients on metformin therapy compared to those who are not taking metformin. Methods: This crosssectional analytical study was conducted at the Department of Medicine, in Sylhet M. A. G. Osmani Medical College &Hospital, Sylhet. Total 100 patients’ withT2DM were selected according to inclusion and exclusion criteria following informed written consent. They were divided into two groups; each groups contains 50 patients. Group-I included patients who were taking metformin for e”1 year and Group-II included patients who were not taking metformin for at least 1 year. Detailed history taking, proper clinical examinations and relevant investigations were done. After collection of all the required data, final analysis was carried out by using the SPSS version 22.0. Results: Among 100 patients of T2DM, mean age were 55.4±15.62 and 55.24±16.76 years, respectively among Group- I and Group-II. They were similar in terms of demographic profile. About 16.0% patients of group- I had vitamin B 12 deficiency and 6.0% had vitamin B 12 deficiency in Group-II. The mean serum Vitamin B 12 was 481.52±283.37 (pgm/mL) in group-I and 600.85±294.2 (pgm/mL) in group-II. The difference of serum Vitamin B 12 was statistically significant (p<0.041) between two groups. Reduced vitamin B 12 also found to be positively associated with duration of metformin intake (p<0.05) and presence of neuropathy (p<0.05). Conclusion: Metformin is significantly associated with decrease the level of vitamin B12. Bangladesh J Medicine 2022; 33: 43-48

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Efficacy of a 28-Day Oral Cyanocobalamin Supplementation on Vitamin B Status in Spanish Institutionalized Elderly

Abstract: A supplementation with an oral supplement solution of 500 µg cyanocobalamin daily for only four weeks, a shorter period than that found in former studies, may be considered suitable in institutionalized elderly.

Cited by 6 publications

References 0 publications

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

A review of the cut-off points for the diagnosis of vitamin B12 deficiency in the general population

A woman with macrocytic anaemia and confusion

Vitamin B12 Status in Long-Term Metformin Treated Type 2 Diabetes Mellitus Patients

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