Efficacy of 5-hydroxytryptamine-3 (5-HT3) antagonists adjuvant therapy for moderate to severe obsessive–compulsive disorder: A systematic review and meta-analysis of randomized clinical trials
Abstract:Background: obsessive–compulsive disorder (OCD) is the fourth most common mental disorder, and selective serotonin reuptake inhibitors (SSRIs) are the cornerstone of its pharmacological treatment. About 40-60% of the cases are treatment-refractory, and this makes searching for second-line treatment necessary. 5-hydroxytryptamine-3 (5-HT3) antagonists are among the many medications that have been used in augmentation with SSRIs.
Objectives: In this systematic review and meta-analysis, we assessed the efficacy … Show more
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