Efficacy of 0.2% chlorhexidine gluconate and 0.1% octenidine dihydrochloride mouth rinses in patients with plaque induced gingivitis: Double blinded randomised case control study.

Abstract

Aims: The study aims at making a comparative study of two commercially available mouth rinses, 0.2% chlorhexidine gluconate and 0.1% octenidine dihydrochloride for assessing their efficacy as an antiplaque agent in patient with plaque induced gingivitis.
 Methods and Material:
 In double-blinded experimental study forty-five patients with dental plaque induced gingivitis, divided into 3 groups of 15 patients each, were advised 0.2% chlorhexidine gluconate (CHX) and 0.1% octenidine dihydrochloride (OCT) and distilled water as a mouth rinses respectively. Clinical parameters viz, Plaque Index, Modified Gingival Index and Gingival Bleeding Index were assessed (day 0, 5,10 and15). Microbial count was also assessed from the collected plaque samples (at day 0 and on day 15). Antimicrobial susceptibility test was also done.
 Statistical analysis used: One- way ANOVA with post hoc test using Tukey, Paired- t test, Mann-Whitney U test, The Kruskal-Wallis test, Wilcoxon signed-rank test
 Results:
 There was significant difference in mean plaque index between the different groups. There was a significant reduction in plaque index for 0.2% CHX The mean modified gingival index was higher in group belonging to 0.1% OCT compared to 0.2% CHX that was statistically significant (p = 0.005). Similarly, the mean gingival bleeding index was significantly higher in group belonging to 0.1% OCT compared to 0.2% CHX (p = 0.005). On day 15 change in the microbial count was statistically significant for 0.2% CHX (p = 0.026).and 0.1% OCT (p = 0.001).
 Conclusions:
 The antimicrobial and antiplaque efficacy (in vivo and in vitro) of 0.1% octenidine dihydrochloride containing mouth rinse was comparatively higher than that containing 0.2% chlorhexidine gluconate thereby demonstrating the former's potential usefulness in controlling plaque and gingivitis.