Efficacy in reducing potassium load in irradiated red cell bags with a potassium adsorption filter

Cid, Joan; Ramiro, Laia; Bertran, Silvia; Martínez, Nathalie Tamayo; Claparols, Montse; Maymó, Rosa Ma; Puig, L.; Pau, Ramon

doi:10.1111/j.1537-2995.2008.01776.x

Cited by 24 publications

(25 citation statements)

References 18 publications

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“…In other words, to maintain electrical neutrality, the number of Na + ions released from the SPS resin is identical to the number of K + , Li + , or H + ions adsorbed by the SPS resin, while two Na + ions are released following adsorption of Mg 2+ or Ca 2+ , and three Na + ions are released following adsorption of Al 3+ . The three earlier studies using this filter showed that the mean reduction in the supernatant K + concentration after a single pass of the stored RBC units was more than 90%, but not 100% . Yamada et al.…”

Section: Discussionmentioning

confidence: 95%

“…Cid et al. reported that the K + concentration decreased from 60.6 to 3.4 mEq/L (mean reduction of 94%) in the supernatant of stored irradiated RBC bags after a single filtration. Yamada et al.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, Cid et al. reported that the filter effectively reduced the K + load in irradiated RBCs. Similarly, Yamada et al.…”

mentioning

confidence: 99%

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Characterization of the Cation‐Binding Capacity of a Potassium‐Adsorption Filter Used in Red Blood Cell Transfusion

Suzuki¹,

Muto

Miyata

et al. 2015

Ther Apher Dial

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A K(+) -adsorption filter was developed to exchange K(+) in the supernatant of stored irradiated red blood cells with Na(+) . To date, however, the filter's adsorption capacity for K(+) has not been fully evaluated. Therefore, we characterized the cation-binding capacity of this filter. Artificial solutions containing various cations were continuously passed through the filter in 30 mL of sodium polystyrene sulfonate at 10 mL/min using an infusion pump at room temperature. The cation concentrations were measured before and during filtration. When a single solution containing K(+) , Li(+) , H(+) , Mg(2+) , Ca(2+) , or Al(3+) was continuously passed through the filter, the filter adsorbed K(+) and the other cations in exchange for Na(+) in direct proportion to the valence number. The order of affinity for cation adsorption to the filter was Ca(2+) >Mg(2+) >K(+) >H(+) >Li(+) . In K(+) -saturated conditions, the filter also adsorbed Na(+) . After complete adsorption of these cations on the filter, their concentration in the effluent increased in a sigmoidal manner over time. Cations that were bound to the filter were released if a second cation was passed through the filter, despite the different affinities of the two cations. The ability of the filter to bind cations, especially K(+) , should be helpful when it is used for red blood cell transfusion at the bedside. The filter may also be useful to gain a better understanding of the pharmacological properties of sodium polystyrene sulfonate.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Characterization of the Cation‐Binding Capacity of a Potassium‐Adsorption Filter Used in Red Blood Cell Transfusion

Suzuki¹,

Muto

Miyata

et al. 2015

Ther Apher Dial

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show abstract

“…190, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207 Transmission of infections, although rare, is a major concern and this risk varies between countries (Table 6). 208, 209, 210, 211 These complications are reviewed extensively elsewhere.…”

Section: Rationalementioning

confidence: 99%

Chapter 4: Red cell transfusion to treat anemia in CKD

2012

Kidney International Supplements

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“…When blood products with increased potassium concentrations are administered to patients with renal dysfunctions, there is a high risk of causing hyperkalemia. In these cases, a filter (KPF-4, Kawasumi Laboratories, Tokyo, Japan) to adsorb the potassium in the red cell bags is useful [1,2]. It has been reported that the filter is effective for use during surgery as large volume blood transfusions are required [3,4], but it is also useful to patients of renal dysfunctions.…”

Section: To the Editormentioning

confidence: 99%

Washing out potassium absorption filters with normal saline after use

et al. 2015

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Efficacy in reducing potassium load in irradiated red cell bags with a potassium adsorption filter

Abstract: This study has shown a high efficacy in reducing potassium load in irradiated RBC bags with the use of the PAF.

Cited by 24 publications

References 18 publications

Characterization of the Cation‐Binding Capacity of a Potassium‐Adsorption Filter Used in Red Blood Cell Transfusion

Characterization of the Cation‐Binding Capacity of a Potassium‐Adsorption Filter Used in Red Blood Cell Transfusion

Chapter 4: Red cell transfusion to treat anemia in CKD

Washing out potassium absorption filters with normal saline after use

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