Efficacy evaluation of antidepressant drugs utilized at tertiary care centre in North Karnataka in psychiatric outpatient department

Abstract

Background: Depression is the major psychotic disorder affecting 9.5% of population worldwide. Present study investigates the prescribing patterns of different antidepressants evaluating their efficacy.Methods: This was a prospective, observational study which was conducted in the out-patient department of Psychiatry and Pharmacology in Gulbarga Institute of Medical Sciences, Kalaburagi. A total of 200 cases were enrolled for the present study. Statistical analysis for efficacy was done using Wilcoxson’s signed rank test.Results: Predominantly, females suffered from depression when compared to male counterparts. In our study, monotherapy was practiced more frequently than polytherapy with 2 or more drugs. Selective serotonin reuptake inhibitors (SSRIs) like Escitalopram was found out to be the most widely used antidepressant drug.Conclusions: Among antidepressant medications, SSRIs are preferred over others because of their better side effect profile.

Research on treatment-related aspects of depression from India in the preceding decade (2014–2023): An updated systematic review

“…The studies comparing different classes of anti-depressants failed to find significant improvements in efficacy with SSRIs or serotonin norepinephrine reuptake inhibitors (SNRIs) over TCAs. [ 26 27 28 32 33 34 35 36 ]…”