Efficacy Evaluation of a Multifunctional Cosmetic Formulation: The Benefits of a Combination of Active Antioxidant Substances

Abstract

This study presents the association of active antioxidants substances in a multifunctional cosmetic formulation with established efficacy against signs of aging. A multifunctional cosmetic formulation containing an association of UV filters and antioxidant substances (liposoluble vitamins A, C and E, Ginkgo biloba and Phorphyra umbilicalis extracts) was evaluated. This formulation was submitted to a clinical efficacy study using biophysics techniques and skin images analysis (digital photography imaging systems, 20 MHz ultrasound, and reflectance confocal microscopy). The volunteers applied the formulation containing the UV filters and antioxidant substances during the day and the formulation with antioxidant substances and without the UV filters at night, for 90 days. The formulation increased the hydration and protected the skin barrier function after a single application. At the long term assessment the formulation provided an improvement in skin barrier function and skin hydration to the deeper layers of the epidermis, leading to an improvement in skin appearance by reducing wrinkles and skin roughness. The multifunctional cosmetic formulation studied can be suggested to preventing signs of aging and improving skin conditions. In addition, this study presents the benefits of associating different active antioxidants substances in a single cosmetic formulation to prevent skin aging.

An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants

“…Our results are in line with other studies which have also given a useful insight into the epidermal and dermal ultra-structural changes after either antioxidant topical application [56] or antioxidant oral supplementation [57][58][59] .…”

Characterization of oily mature skin by biophysical and skin imaging techniques

“…The stratum corneum water content (hydration) was determined by a non‐invasive, skin capacitance meter (Corneometer ® CM 825, Courage & Khazaka, Cologne, Germany), which measures capacitance and is entirely dependent of the water content in the skin. Different capacitance changes are converted into a digital measured value (arbitrary units) which is proportional to the skin humidity and results are given in arbitrary units (AU) estimated to correspond 1 AU in 0.2‐0.9 mg of water per gram of stratum corneum . This parameter was analyzed on the frontal and malar regions of the face.…”

“…The ultrasonic wave (speed of 1580 m s −1 ) is partially reflected by the skin structure, giving rise to echoes of different amplitudes. To calculate the echogenicity, the number of pixels with low echogenicity is measured by means of the image analysis software and related to the total number of pixels . The echogenicity ratio was calculated as a ratio of number of low echogenical pixels and number of total echogenical pixels (LEP/TEP).…”

Assessment of skin pigmentation by confocal microscopy: Influence of solar exposure and protection habits on cutaneous hyperchromias

“…The VisioFace ® Quick equipment provides images of skin illuminated by a white light‐emitting diode (white LED) and light‐emitting diodes similar to UV (UV‐like LED) allowing the detection of visible spots and those visible only under UV light. The software also calculates the percentage of pores, lines and wrinkles, and homogeneity of skin texture in the images obtained …”