Efficacy, Cost, and Complications of Demineralized Bone Matrix in Instrumented Lumbar Fusion: Comparison With rhBMP-2

Eleswarapu, Ananth; Rowan, Flynn Andrew; Le, Hai; Wick, Joseph; Roberto, Rolando Figueroa; Javidan, Yashar; Klineberg, Eric O.

doi:10.1177/2192568220942501

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…In rhBMP-2 group radiographic complication rate was 33% (7/21). However in DBM side complication rate was zero [33]. Despite these positive ndings of DBM, two patients had complications in our series.…”

Section: Discussionmentioning

confidence: 52%

Low-Grade Chondrosarcomas: Diagnosis and Treatment

Erdoğan¹,

Demiröz²,

Kaya³

et al. 2021

Preprint

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Background: Multiple parameters are needed to distinguish between enchondroma and low-grade chondrosarcoma (LGCS). This study aimed to investigate the diagnosis, surgery type according to bone type, recurrence rates, and complications of LGCS in the appendicular and axial skeletons. Methods: A total of 52 surgically treated patients with LGCS, between March 2007 and May 2019, were retrospectively examined. Following diagnosis, the patients were operated on with intralesional curettage for long bones or wide local excision (WLE) for axial bones. The retrieved data included demographics, tumor location, surgical treatment type, local adjuvants, complications, and Musculoskeletal Tumor Society scores.Results: The final cohort included 52 patients (52 tumors; 35 female and 17 male). The male:female ratio was 1:2. The mean age was 44 ± 17 years. Forty of the tumors were treated with intralesional procedures (all with a high-speed burr and phenol), 6 with autograft, 8 with allograft, and 28 with cement augmentation, while 7 were treated with WLE.Conclusions: The use of phenol as an adjuvant may reduce recurrence rates. Using a putty graft alone may result in nonunion. Applying a thin layer of putty on the cementum can create callus tissue on the cementum. Even in the upper limb, plate and screw fixation should be used to prevent fractures in metaphyseal–diaphyseal curettages.

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Section: Discussionmentioning

confidence: 52%

Low-Grade Chondrosarcomas: Diagnosis and Treatment

Erdoğan¹,

Demiröz²,

Kaya³

et al. 2021

Preprint

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“…They will be used in a separate study to develop evidence-based recommendations for economic evaluations in spine surgery. Finally, a total of 130 clinical cost-effectiveness studies were included 24–153…”

Section: Resultsmentioning

confidence: 99%

Methodology of economic evaluations in spine surgery: a systematic review and qualitative assessment

et al. 2023

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ObjectivesThe present study is a systematic review conducted as part of a methodological approach to develop evidence-based recommendations for economic evaluations in spine surgery. The aim of this systematic review is to evaluate the methodology and quality of currently available clinical cost-effectiveness studies in spine surgery.Study designSystematic literature review.Data sourcesPubMed, Web of Science, Embase, Cochrane, Cumulative Index to Nursing and Allied Health Literature, EconLit and The National Institute for Health Research Economic Evaluation Database were searched through 8 December 2022.Eligibility criteria for selecting studiesStudies were included if they met all of the following eligibility criteria: (1) spine surgery, (2) the study cost-effectiveness and (3) clinical study. Model-based studies were excluded.Data extraction and synthesisThe following data items were extracted and evaluated: pathology, number of participants, intervention(s), year, country, study design, time horizon, comparator(s), utility measurement, effectivity measurement, costs measured, perspective, main result and study quality.Results130 economic evaluations were included. Seventy-four of these studies were retrospective studies. The majority of the studies had a time horizon shorter than 2 years. Utility measures varied between the EuroQol 5 dimensions and variations of the Short-Form Health Survey. Effect measures varied widely between Visual Analogue Scale for pain, Neck Disability Index, Oswestry Disability Index, reoperation rates and adverse events. All studies included direct costs from a healthcare perspective. Indirect costs were included in 47 studies. Total Consensus Health Economic Criteria scores ranged from 2 to 18, with a mean score of 12.0 over all 130 studies.ConclusionsThe comparability of economic evaluations in spine surgery is extremely low due to different study designs, follow-up duration and outcome measurements such as utility, effectiveness and costs. This illustrates the need for uniformity in conducting and reporting economic evaluations in spine surgery.

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“…To the best of our knowledge, no previous study has reported the rate of pseudarthrosis following ASD surgery including DBM. As a surrogate measurement, we found that several studies suggest non-inferior fusion rates when comparing DBM as an adjunct to local autologous autograft with iliac crest bone graft (ICBG), allograft and Bone Morphogenetic Protein-2 (BMP-2) following lumbar fusion surgery ( Buser et al., 2018 ; Fu et al., 2016 ; Han et al., 2020 ; Eleswarapu et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%