Efficacy and Versatility of the 3-D Titanium Mesh Implant in the Closure of Large Post-Craniectomy Osseous Defects, and its Therapeutic Role in Reversing the Syndrome of the Trephined: Clinical Study of a Case Series and Review of Literature

Jeyaraj, Priya

doi:10.1007/s12663-015-0807-0

Cited by 14 publications

(11 citation statements)

References 36 publications

(36 reference statements)

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“…The overall histological and radiographic results show a survival and success rate of 100% according to Albrektsson et al . 27 , confirming our previous hypothesis that the combination of Bio-Gide membrane and titanium mesh may achieve an enhanced bone regeneration effect.…”

Section: Discussionsupporting

confidence: 89%

“…13 reported the use of titanium mesh in GBR to repair severe alveolar defects at implant sites. Recently, the use of a rigid titanium mesh, stabilized as a tent over a resorbed ridge in full/partial restoration of the alveolar process, has been reported 14 , 15 . The porous titanium mesh can cover the alveolar defects to form the ideal shape of the alveolar ridge, thus effectively preventing soft tissue collapse and displacement of bone particles during bone regeneration 16 , 17 .…”

Section: Introductionmentioning

confidence: 99%

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Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs

Li¹,

Zheng²,

Zhang³

et al. 2018

Sci Rep

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To guide barrier membrane choice in the treatment of peri-implant alveolar bone defects, we evaluated guided bone regeneration (GBR) using titanium (Ti) mesh or Bio-Gide membrane, independently or in combination, for repair of alveolar bone defects in Beagle dogs. Six months after extraction of the mandibular premolars and first molars from three beagle dogs, we inserted implants assigned into 3 groups and covered with the following membrane combinations: Group A: Implant + Bio-Oss + Ti-mesh, Group B: Implant + Bio-Oss + Bio-Gide, and Group C: Implant + Bio-Oss + Ti-mesh + Bio-Gide. At 6 months, micro-CT revealed that bone volume/total volume (BV/TV), trabecular number (Tb.N), and trabecular thickness (Tb.Th) was significantly greater in Group C than the other two groups, while trabecular separation (Tb.Sp) was significantly lower, suggesting improved bone regeneration. The distance between bands of three fluorescent tracking dyes was significantly greater in Group C, indicating faster deposition of new bone. The Bio-Oss particles were ideally integrated with newly deposited bone and bone thickness was significantly larger in Group C. These findings suggest that combination of Bio-Gide membrane and titanium mesh can effectively repair peri-implant alveolar bone defects, achieving enhanced bone regeneration compared to titanium mesh or Bio-Gide alone, and therefore providing a novel treatment concept for clinical implant surgery.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Experiment of GBR for repair of peri-implant alveolar defects in beagle dogs

Li¹,

Zheng²,

Zhang³

et al. 2018

Sci Rep

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“…Previous methods of cranioplasty in dogs are not ideal and recently the use of titanium mesh has been described in a small subset of dogs with good outcomes [1]. In humans it has been shown that titanium mesh can provide a safe and reliable implant that allows for postoperative CT and magnetic resonance imaging [13]. Despite this benefit, it does not always provide a cosmetic solution or one that reduces surgery time, speeds healing, or improves clinical outcome [6,8,9].…”

Section: Discussionmentioning

confidence: 99%

Schedule feasibility and workflow for additive manufacturing of titanium plates for cranioplasty in canine skull tumors

et al. 2020

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Background: Additive manufacturing has allowed for the creation of a patient-specific custom solution that can resolve many of the limitations previously reported for canine cranioplasty. The purpose of this pilot study was to determine the schedule feasibility and workflow in manufacturing patient-specific titanium implants for canines undergoing cranioplasty immediately following craniectomy. Results: Computed tomography scans from patients with tumors of the skull were considered and 3 cases were selected. Images were imported into a DICOM image processing software and tumor margins were determined based on agreement between a board-certified veterinary radiologist and veterinary surgical oncologist. Virtual surgical planning was performed and a bone safety margin was selected. A defect was created to simulate the planned intraoperative defect. Stereolithography format files of the skulls were then imported into a plate design software. In collaboration with a medical solution centre, a custom titanium plate was designed with the input of an applications engineer and veterinary surgery oncologist. Plates were printed in titanium and post-processed at the solution centre. Total planning time was approximately 2 h with a manufacturing time of 2 weeks. Conclusions: Based on the findings of this study, with access to an advanced 3D metal printing medical solution centre that can provide advanced software and printing, patient-specific additive manufactured titanium implants can be planned, created, processed, shipped and sterilized for patient use within a 3-week turnaround.

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“…Compared to alloplastic materials, autogenous calvarial bone grafts present better mechanical, biological, and immunological characteristics (13) . Nevertheless, titanium mesh implant is an alternative to calvarial grafts, especially in cases with large cranial defects, as it is inert, malleable and has the ability to osseointegrate (14) . Additionally, advanced 3D printing techniques have permitted the manufacturing of porous titanium implants, customised to the individual needs of patients with such defects, without leaving any dead space, but at a rather high cost (15) .…”

Section: Discussionmentioning

confidence: 99%