Efficacy and toxicity of plasmonic photothermal therapy (PPTT) using gold nanorods (GNRs) against mammary tumors in dogs and cats

Abdoon, Ahmed S.; Al-Ashkar, Emad A.; Kandil, Omaima M.; Shaban, A. M.; Khaled, Hussein M.; Sayed, Moustafa A. El; Shaer, Marwa M. El; Shaalan, A H; Eisa, Wael H.; Eldin, Amina A. Gamal; Hussein, Hany A.; Ashkar, Mohammad R. El; Ali, Moustafa R. K.; Shabaka, A. A.

doi:10.1016/j.nano.2016.07.005

Cited by 37 publications

(38 citation statements)

References 35 publications

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“…c) A photo of the abdomen of a dog with a natural mammary tumor before (left and center) and after being treated with photothermal therapy (right). Reproduced with permission . Copyright 2016, Elsevier.…”

Section: Heating Up the Environmentmentioning

confidence: 99%

Section: Heating Up the Environmentmentioning

confidence: 99%

“…PTT has been tested both in vitro and in vivo in animal models . Figure b shows results of photothermal treatment of mice with human prostate cancer performed by Stern et al The authors injected polyethylene glycol (PEG) coated Au nanoshells with 110 nm SiO 2 core and 10 nm Au shell into tail veins of the mice.…”

Section: Heating Up the Environmentmentioning

confidence: 99%

“…The illumination and subsequent heating cause localized hyperthermia to the cancerous tissue, with little effect on the surrounding healthy tissue. The therapy has been successfully demonstrated in vivo, on several animal models (mouse, cat, and dog), and it has proceeded to clinical trials on humans . An important limitation however is the cost of the therapy, with an estimated cost of $7500 for a single treatment .…”

Section: Introductionmentioning

confidence: 99%

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“Hot” in Plasmonics: Temperature‐Related Concepts and Applications of Metal Nanostructures

Kuppe

Rusimova

Ohnoutek

et al. 2019

Advanced Optical Materials

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Recent advances in nonlinear optics, hot electrons for renewable energy (e.g., solar cells and water‐splitting), acousto‐optics, nanometalworking, nanorobotics, steam generation, and photothermal cancer therapy are reviewed here. In all these areas, one of the key enabling properties is the ability of metallic nanoparticles to harvest and control light at the subwavelength scale by supporting coherent electronic oscillations, called localized surface plasmon resonances (LSPRs). Various physical properties and potential areas of application emerge depending on the decay mechanism of the LSPR and, especially, depending on the considered timescale. The field of plasmonics has mainly been associated with manipulating electromagnetic near‐fields at the nanoscale, where absorption is an obstacle. However, plasmonic absorption leads to a stream of temperature‐related phenomena that have only recently attracted significant attention. The goal of this review is to highlight exciting new areas of research (such as nanorobotics, nanometalworking, or acousto‐optical techniques) and to survey the most recent progress in more established areas (such as hot electrons, photothermal therapy, and plasmonic steam generation). To set each research area in context, the text is organized around the thermal cycle of the nanoparticles.

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Section: Heating Up the Environmentmentioning

confidence: 99%

Section: Heating Up the Environmentmentioning

confidence: 99%

Section: Heating Up the Environmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

“Hot” in Plasmonics: Temperature‐Related Concepts and Applications of Metal Nanostructures

Kuppe

Rusimova

Ohnoutek

et al. 2019

Advanced Optical Materials

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“…However, the establishment of non-invasive therapeutic approaches for mammary carcinomas is currently addressed in various ways. A recent study reported a non-invasive treatment option for mammary tumours in dogs and cats using plasmonic photothermal therapy [33]. Due to disease similarities between humans and dogs, similar environmental conditions, but easier performable trials (guidelines are less strict than for humans), dogs are considered to represent an excellent model for human diseases [34].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines

Hammer

Becker

Rateitschak

et al. 2016

IJMS

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Human and canine mammary tumours show partial claudin expression deregulations. Further, claudins have been used for directed therapeutic approaches. However, the development of claudin targeting approaches requires stable claudin expressing cell lines. This study reports the establishment and characterisation of canine mammary tissue derived cell lines, analysing longitudinally the claudin-1, -3, -4 and -7 expressions in original tissue samples, primary cultures and developed cell lines. Primary cultures were derived from 17 canine mammary tissues: healthy, lobular hyperplasia, simple adenoma, complex adenoma, simple tubular carcinoma, complex carcinoma, carcinoma arising in a benign mixed tumour and benign mixed tissue. Cultivation was performed, if possible, until passage 30. Claudin mRNA and protein expressions were analysed by PCR, QuantiGene Plex Assay, immunocytochemistry and immunofluorescence. Further, cytokeratin expression was analysed immunocytochemically. Cultivation resulted in 11 established cell lines, eight showing epithelial character. In five of the early passages the claudin expressions decreased compared to the original tissues. In general, claudin expressions were diminished during cultivation. Three cell lines kept longitudinally claudin, as well as epithelial marker expressions, representing valuable tools for the development of claudin targeted anti-tumour therapies.

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Plasmonic‐Pyroelectric Materials and Structures

Wang,

Bowen,

Valev

2024

Adv Funct Materials

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With the growing global energy crisis, research into new energy materials that can potentially transfer heat into electricity has become a worldwide imperative. Pyroelectric materials are polar materials that are able to produce electrical charge in response to temperature change. These materials are of interest for infrared sensing, energy harvesting, and emerging applications in chemistry and biology. However, unlocking their potential requires the temperature changes to be both large and rapid. To achieve this goal, pyroelectric materials can be used in synergy with plasmonic nanomaterials, which provide highly localized and rapid heating upon illumination at the plasmonic resonances. Plasmonic‐pyroelectric combinations are therefore being used for a variety of electrical, thermal, electrochemical, and biological studies and are inspiring new technological applications. In this review, the underlying mechanisms of the pyroelectric and plasmonic effects are introduced and the benefits of combining them are outlined. A range of applications is then overviewed. Critical challenges and future perspectives to further develop the underlying science of these systems and to create highly efficient plasmonic‐pyroelectric materials and structures are discussed.

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Efficacy and toxicity of plasmonic photothermal therapy (PPTT) using gold nanorods (GNRs) against mammary tumors in dogs and cats

Cited by 37 publications

References 35 publications

“Hot” in Plasmonics: Temperature‐Related Concepts and Applications of Metal Nanostructures

“Hot” in Plasmonics: Temperature‐Related Concepts and Applications of Metal Nanostructures

Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines

Plasmonic‐Pyroelectric Materials and Structures

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