Abstract:PURPOSE Depression is common in primary care. There are no systematic reviews of depression treatment comparing antidepressants with placebo; hence, we do not know whether these medications are effective in primary care.
METHODSWe searched the Cochrane Collaboration Depression, Anxiety and Neurosis Group register of controlled trials, MEDLINE, International Pharmaceutical abstracts, PsycINFO, and EMBASE. Abstracts of potential studies were reviewed independently by 2 authors. Studies needed to include randomiz… Show more
“…1,2 These drugs have been shown to be more effective than placebo in the treatment of depression in primary care. 3 Continuation of treatment following remission of depression is associated with a reduced risk of early relapse and in patients who have already experienced depressive episodes, longterm treatment substantially reduces the risk of further episodes. 4 Consequently, national and international guidelines recommend that antidepressant treatment should be continued for around 6 months after recovery from an initial episode.…”
“…1,2 These drugs have been shown to be more effective than placebo in the treatment of depression in primary care. 3 Continuation of treatment following remission of depression is associated with a reduced risk of early relapse and in patients who have already experienced depressive episodes, longterm treatment substantially reduces the risk of further episodes. 4 Consequently, national and international guidelines recommend that antidepressant treatment should be continued for around 6 months after recovery from an initial episode.…”
“…Given that the most recently available evidence refers to the SSRIs as a homogeneous group (Arroll 2005;, it is still unclear how each of the SSRIs or newer agents compare with other antidepressants in terms of effects and side effects.…”
“…Their analysis confirms the results of previous studies that suggest psychological therapies are probably as effective as antidepressant treatment. A meta-analysis of antidepressant treatment in primary care 19 found an NNT for selective serotonin reuptake inhibitors of around 6.0.…”
Section: Managing Depression In Primary Carementioning
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