Efficacy and Tolerability of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan Intradermal Injections for the Treatment of Skin Roughness and Laxity of the Neck

Abstract

This study aimed to evaluate the efficacy of a well-characterized formulation of hyaluronic acid (HA), Profhilo®, in the treatment of roughness and laxity of the neck skin. The study was performed on 25 subjects ranging in age from 40 to 65 years. Two injections of the studied product at 30-day intervals were performed, with evaluations conducted 1 and 4 months after the first injection. The efficacy was determined by clinical and multilevel instrumental evaluations. In addition, at the end of the study, the subjects completed a questionnaire related to the efficacy and tolerability of the product. The studied product was shown to induce a clear and statistically significant improvement in the skin of the neck in all the subjects, with concordant results between the clinical, instrumental, and subjects’ evaluations. The positive effects, present after the first injection, were further increased in the second and last evaluation. Notably, the product was reported to have a very high tolerability by both clinicians and subjects. In conclusion, two injections of the studied product safely induced skin amelioration in subjects with mild to moderate neck skin roughness and laxity.

Efficacy and tolerability of Profhilo® Structura intended to restore lateral cheek fat compartment: An observational pilot study

“…The patented NAHYCO ® technology enables the delivery of HCC comprising low and high molecular weight HA characterized by increased stability and resistance to hyaluronidase degradation, 22 and its ability to sustain skin cell vitality and proliferation. 22,24 Moreover, HCC (commercial name, Profhilo ® ) demonstrated efficacy in clinical studies for improving facial appearance 25 and counteracting skin laxity 26 with a high safety profile. 27 This monocentric study aimed to evaluate the efficacy and tolerability of Profhilo Structura ® (a new formulation containing a higher concentration of HA; 45 mg/mL) injected into the lateral cheek fat compartment in a cohort of 50 healthy female subjects.…”

Intradermal Injection of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan: Where Do We Stand and Where Are We Headed in Regenerative Medicine?

“…Indeed, three independent in vivo studies, performing two facial subcutaneous injections with a 4-week time lapse between them, resulted in a significant improvement in facial face hydration, elasticity, and transepidermal water loss (TEWL), as well as in high patient satisfaction and optimal physician evaluations [ 30 , 31 , 32 , 33 ]. Importantly, HCC benefits were present in the absence of local side effects, as demonstrated by post-marketing surveillance data [ 31 ] and by long-term safety studies [ 34 ]. Moreover, treatment with HCCs proved to be effective not only for White populations, but also for different ethnicities.…”

“…Goltsova et al [ 35 ] and Satardinova et al [ 36 ] demonstrated significative amelioration of skin texture and hydration in the Russian and Oriental Mongolian population. Furthermore, a recent clinical study also proved that HCC treatment is effective in improving the facial appearance of Asian women, even earlier compared to White women [ 37 , 38 ].…”

“…Paganelli et al obtained similar promising data on the use of HCCs combined with plasma exeresis for neck rejuvenation, with an improvement in both patient- and physician-assigned neck skin laxity scores, excellent tolerability evaluations, and only transient and mild side effects such as erythema and oedema [ 42 ]. Sparavigna et al reported amelioration after injection of HCCs in the neck area in terms of skin roughness and laxity based on clinical, instrumental, and subjective evaluations [ 43 ]. The clinical study showed a statistically significant improvement in neck skin laxity, which was already detectable at 1 month after the first aesthetic procedure and further increased at 4 months.…”

“…The clinical study showed a statistically significant improvement in neck skin laxity, which was already detectable at 1 month after the first aesthetic procedure and further increased at 4 months. This improvement was associated with a reduction in the IBSA Neck Laxity Scale of at least 1 grade in more than half of the subjects [ 43 ]. Comparable to research on face rejuvenation, HCCs were proven to be effective for neck rejuvenation not only on in White populations, but also in different ethnicities (Asian women) [ 37 ].…”