Efficacy and Tolerability of Famotidine in Preventing Heartburn and Related Symptoms of Upper Gastrointestinal Discomfort

Gottlieb, Stanley; Decktor, Dennis L.; Eckert, Joanne M.; Simon, Thomas; Stauffer, Laura; Ciccone, Patrick E.

doi:10.1097/00045391-199505000-00004

Cited by 15 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have used provocative meals with various noxious components to evaluate antacids and antisecretory drugs for heartburn prophylaxis and/or treatment 9 , . 10 , 18 , 19 The lack of a standardized meal has led to studies of the effects of several meals designed to reliably produce gastro‐oesophageal reflux and heartburn 11 . The refluxogenic meal used in this study (chilli with cheese and onions, and a caffeinated soft drink) was slightly modified from the report by Rodriguez et al ., 11 and contained no measurable capsaicin which could be considered a noxious component.…”

Section: Discussionmentioning

confidence: 99%

Effects of antacid formulation on postprandial oesophageal acidity in patients with a history of episodic heartburn

Robinson¹,

Rodriguez–Stanley²,

Miner³

et al. 2002

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Heartburn occurs intermittently in more than 30% of otherwise healthy individuals and is almost always associated with acidic gastro-oesophageal re¯ux. 1±3 In addition, heartburn and related symptoms can be produced by certain`provocative' foods 1,4,5 or by overindulgence in food and drink. 6 Antacids are popular`over-the-counter' preparations for the relief of episodic heartburn, and have been assumed to assuage heartburn by neutralizing gastric acid, thus preventing subsequent acidic gastro-oesophageal re¯ux. 7,8 With large antacid doses (e.g. 156 mmol), fed subjects demonstrate signi®cantly elevated gastric pH. However, more recent studies have indicated that usual doses of antacids are primarily active in the distal oesophageal lumen 9, 10 rather than by neutralization of intragastric contents. If this is indeed the case, chewable antacids should rapidly increase and sustain the elevated intra-oesophageal pH better than swallowable antacids. The use of standardized meals eliminates a signi®cant variable in re¯ux and heartburn studies. In a previous SUMMARY Background: Heartburn self-treatment with antacids is extremely common. If the oesophagus is the primary site of antacid action, chewable antacids might raise the oesophageal pH more effectively than swallowable tablets. Aim: To establish a model to assess postprandial acid re¯ux and to compare the onset and duration of action on oesophageal pH of different antacid formulations. Methods: Twenty subjects with a history of episodic heartburn underwent eight pH monitoring sessions each for 5.5 h postprandially. One hour after consuming a meal consisting of chilli, cheese, raw onions and cola, subjects received 750 mg, 1500 mg and 3000 mg of either chewable or swallowable CaCO 3 tablets, an effervescent bicarbonate solution or placebo. Oesophageal and gastric pH data were collected.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of antacid formulation on postprandial oesophageal acidity in patients with a history of episodic heartburn

Robinson¹,

Rodriguez–Stanley²,

Miner³

et al. 2002

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Since 1995, these H 2 -antagonists have become available for the non-prescription treatment or prevention of heartburn in the USA, the UK, and a number of other countries, based upon successful placebo-controlled clinical trials. 6,17,24,25 The nonprescription H 2 -antagonists were approved to treat and/ or prevent heartburn, a condition that may be selfdiagnosed.…”

Section: Discussionmentioning

confidence: 99%

“…The use of a standardized provocative meal has been questioned in terms of its applicability to real life situations. This model evolved from the work of several groups of clinical scientists 6,25,28 and is designed to produce heartburn in the majority of patients who experience spontaneous meal-induced heartburn. Friedman et al 28 examined the severity and reproducibility of heartburn symptoms in response to two consecutive meals and concluded that meal-induced heartburn is reproducible and provides a scienti®cally valid model to assess the effects of study medications upon heartburn symptoms.…”

Section: Discussionmentioning

confidence: 99%

“… 2 Heartburn is most frequently associated with food and beverage consumption and especially occurs after ingestion of certain foods or food groups 2 –4 . Fried, spicy or fatty foods, and cola or alcohol are the most common meal‐related factors precipitating heartburn 5 –7 . Similarly, irritants such as cayenne or capsaicin and pepper‐containing foods, like chilli, may both stimulate gastric acid secretion and also act as a direct irritant 8 –10…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A double‐blind, placebo‐controlled study of the efficacy and safety of non‐prescription ranitidine 75 mg in the prevention of meal‐induced heartburn

Pappa

Williams

Payne

et al. 1999

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Background : Ranitidine 75 mg (Zantac 75) has been shown to be effective for the treatment of pre‐existing heartburn symptoms. Aim : To compare the efficacy of dosing ranitidine 75 mg or placebo 30 min prior to a proven heartburn‐provoking meal in completely preventing or reducing subsequent heartburn symptoms. Methods : A randomized, double‐blind, parallel methodology was used at nine investigative centres. Following a screening visit, patients ate a standard test meal consisting of chilli, chips and a soft drink on two occasions. On the first occasion, patients received single‐blind placebo 30 min before the meal. This meal was used to qualify patients and to ensure the onset of a minimum level of heartburn. Patients who qualified were randomized (n = 284) to receive double‐blind ranitidine 75 mg or placebo 30 min before a second test meal administered 4–14 days later at the treatment visit. Patients recorded whether heartburn was present and rated heartburn severity by completing visual analogue scales at 15‐min intervals over the 4.5 h meal evaluation periods. Results : Statistically significant differences favouring ranitidine 75 mg were determined for complete prevention of heartburn (P < 0.006), heartburn severity area under the curve (P < 0.001), a clinical success end‐point (P < 0.001), and all other end‐points (P < 0.001). Conclusions : These data clearly demonstrate that ranitidine 75 mg is effective in completely preventing or decreasing heartburn when administered 30 min prior to a provocative meal.

show abstract

A Double-blind, Placebo-Controlled Study of the Effectiveness and Safety of Nizatidine in the Prevention of Postprandial Heartburn

Spiegel

Thoden²,

Pappas³

et al. 1997

Arch Intern Med

View full text Add to dashboard Cite

show abstract

Efficacy and Tolerability of Famotidine in Preventing Heartburn and Related Symptoms of Upper Gastrointestinal Discomfort

Cited by 15 publications

References 0 publications

Effects of antacid formulation on postprandial oesophageal acidity in patients with a history of episodic heartburn

Effects of antacid formulation on postprandial oesophageal acidity in patients with a history of episodic heartburn

A double‐blind, placebo‐controlled study of the efficacy and safety of non‐prescription ranitidine 75 mg in the prevention of meal‐induced heartburn

A Double-blind, Placebo-Controlled Study of the Effectiveness and Safety of Nizatidine in the Prevention of Postprandial Heartburn

Contact Info

Product

Resources

About