Efficacy and tolerability of celecoxib versus hydrocodone/acetaminophen in the treatment of pain after ambulatory orthopedic surgery in adults

Gimbel, Joseph; Brugger, Andrew; Zhao, Wen; Verburg, Kenneth M.; Geis, Gilbert

doi:10.1016/s0149-2918(01)80005-9

Cited by 142 publications

(97 citation statements)

References 16 publications

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“…The analgesic effects of celecoxib were confirmed in patients undergoing tooth extraction or orthopedic surgery (Lefkowith, 1999;Gimbel et al, 2001). A double blind study of post orthopedic pain in 418 patients compared 200 mg of celecoxib with 10 mg of hydrocodone/ 1000 mg of paracetamol.…”

Section: A Treatment Of Inflammatory Diseasesmentioning

confidence: 98%

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Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

2004

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Section: A Treatment Of Inflammatory Diseasesmentioning

confidence: 98%

“…A double blind study of post orthopedic pain in 418 patients compared 200 mg of celecoxib with 10 mg of hydrocodone/ 1000 mg of paracetamol. Both treatments were effective in producing analgesia with fewer doses of celecoxib needed to ease the pain (Gimbel et al, 2001).…”

Section: A Treatment Of Inflammatory Diseasesmentioning

confidence: 99%

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

2004

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“…The theory behind the preoperative administration of selective COX-2 inhibitors is that inhibition of COX-2-mediated prostaglandin synthesis reduces nociceptive pain and prevents inflammatory-induced hyperalgesia. 7 Celecoxib, a COX-2-selective NSAID, has been shown to be effective in relieving pain associated with orthopedic surgery, 8 arthroscopic knee surgery, 9 and ankle sprain, 10,11 as well as dental surgery. [9][10][11] Celecoxib has been shown to be well tolerated and associated with a lower incidence of endoscopically detected gastric and duodenal ulcers than nonselective NSAIDs such as aspirin and its derivatives.…”

Section: Introductionmentioning

confidence: 99%

Effect of Celecoxib on Emotional Stress and Pain-Related Behaviors Evoked by Experimental Tooth Movement in the Rat

Shibazaki

Yozgatian²,

Zeredo

et al. 2009

The Angle Orthodontist

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Objective: To test the efficacy of an animal model of pain and stress and evaluate the effects of celecoxib administered when orthodontic force is applied. Materials and Methods: A 20-g reciprocal force was applied via an orthodontic appliance to the maxillary left first and second molars of 7-week-old male Sprague-Dawley rats. Rat behavior was evaluated at 5, 24, and 48 hours after the appliance was set. Behavior was assessed in a test field by the number of lines crossed in the first 30 seconds and 5 minutes following force application; number of lines crossed to the center; rearing time; and facial grooming time. Experimental group 1 received intraperitoneal administration of 30 mg/kg celecoxib before every behavioral test. Experimental group 2 received 90 mg/kg before the first behavioral test, and physiologic saline was administered before the remaining behavioral tests. Control groups received saline before every behavioral test and were given passive (passive control group) and active (active control group) appliances, respectively. Results: Parameters related to pain increased in the active controls, whereas the parameters in the experimental groups decreased to the level seen in the passive controls. Statistically significant differences in pain-related behavior between control and experimental groups were found at 5 and 24 hours after placing the appliance. Stress-related behavior was significantly less in the experimental groups compared to the active control group during experimental periods. Conclusions:The administration of celecoxib relieves pain-and stress-related behavior evoked by orthodontic tooth movement in the rat. This model might be a useful tool for the evaluation of pain and stress.

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“…Th e same reviewer assessed the full text articles and determined that 14 of the 26 off ered quantitative results that could be analyzed using the GRADE-pro software [28][29][30][31][32][33][34][35][36][37][38][39][40][41]. Th e remaining 12 articles were excluded because they did not compare both drugs assessed in a PICO question [42][43][44][45][46][47], compared analgesics not addressed in the seven P ICO qu estions (such as acetaminophen alone) [48,49], used unconventional medication dosing [50,51], used non-validated pain me asurement scales [52,53], and/or unusual study designs [50].…”

Section: Resultsmentioning

confidence: 99%

Analgesia in the Emergency Department: A GRADE-based Evaluation of Research Evidence and Recommendations for Practice

Lipp

Dhaliwal

Lang

2013

Annual Update in Intensive Care and Emergency Medicine 2013

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Emergency physicians care for patients with pain on an extremely frequent basis [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Th e prevalence of pain as the presenting complaint of patients seeking eme rgen cy department (ED) care ranges from 38 % [3] to as high as 78 % [1]. As a result, evidence-based use of analgesics should be a foundational skill of emergency physicians. However, the literature consistently reports that emergency physicians are ofte n poor at treating pain [1,2,8,13,14,16,19,20] . Notwithstanding the prevalence of pain in the ED, many patients often report that their pain was no t pr oper ly t reated [3,7,20]. I n addi tion to a compromised patient experience, sub-optimal treatment of pain will result in decreased department fl ow, increased wait times, more return visits to the ED, and increased hospitalization rates.Very few evidence-based resources and guideli nes exis t to inform emergency physicians on how to treat pain. One recent guideline on acute pain management compiled by the college of Anaesthetists of Australia and New Zealand [21] was focused primarily on treating pain perioperatively and did not include stratifi ed or graded recommendations based on the literature, highlighting the paucity of emergency medicine-specifi c guidance. Emergency physicia ns need an eff ective, evidenced-based approach to analyze and apply the options available for acute pain management.Th e objective of this article is to synthesize and evaluate the quality of medical literature surrounding analgesia delivery in the adult ED using the Grading Assessment, Development and Evaluation (GRADE) framework. We further strived to provide emergency physicians with graded recommendations upon which analgesics should be used to treat adults with acute pain in the ED. Question formulationPrior to searching the literature we developed seven clinically-oriented questions based on a scoping of the literature and a review of locally utilized ED analgesic order sets. Th is initial surveying of medical literature and our local practice environment allowed us to identify the most commonly prescribed intravenous and oral analgesics used in adult EDs in our health care region.We then used the patient-intervention-comparisonoutcome (PICO) approach to develop our seven research questions (Table 1). Th is approach has been adopted by many authors of systematic reviews and guideline panels, including the Internati onal Liaison Committee on Resuscitation (ILCOR) and the American College of Chest Physicians (ACCP) [22][23][24]. It involves identifying a specifi c population or setting to which recommen dations may be applied. Subseq uently each question compares two specifi c management strategies (intervention and comparison). Fi nally, we defi ned important patient oriented outcomes (e. g., change in pain) as well as any adverse eff ects of the medication or other safety concerns.All seven draft questions were reviewed and revised through an iterative process involving all authors. Th ese seven cl...

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Efficacy and tolerability of celecoxib versus hydrocodone/acetaminophen in the treatment of pain after ambulatory orthopedic surgery in adults

Cited by 142 publications

References 16 publications

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

Effect of Celecoxib on Emotional Stress and Pain-Related Behaviors Evoked by Experimental Tooth Movement in the Rat

Analgesia in the Emergency Department: A GRADE-based Evaluation of Research Evidence and Recommendations for Practice

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