Efficacy and tolerability of antiasthma herbal medicine intervention in adult patients with moderate-severe allergic asthma

Wen, Mingchun; Chunhua, Wei; Hu, Zhao-qiu; Srivastava, Kamal; Ko, Jimmy; Xi, Su-ting; Mu, Dongzhen; Du, Ji-Bin; Li, Guohua; Wallenstein, Sylvan

doi:10.1016/j.jaci.2005.05.029

Cited by 170 publications

(138 citation statements)

References 32 publications

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“…Clinical symptom scores, use of β2-bronchodilators, serum IgE level, serum IL-5, IL-13 concentrations are all reduced, and some effects are even better than prednisone. During the study no adverse effect were recorded [298]. These results indicate the effectiveness of ASHMI on treating asthma in both young and old adult patients.…”

Section: Anti-asthma Herbal Medicine Intervention (Ashmi)supporting

confidence: 58%

Asthma in the 21st Century — Unexpected Applications of Ancient Treatments

Pundir¹,

Kulka²

2013

Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century

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Section: Anti-asthma Herbal Medicine Intervention (Ashmi)supporting

confidence: 58%

Asthma in the 21st Century — Unexpected Applications of Ancient Treatments

Pundir¹,

Kulka²

2013

Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century

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“…[12;13] We found that ASHMI had comparable effects on AHR and eosinophilic inflammation to the classical 14-herb formulation and showed a high safety profile in an animal model of asthma. [13] Consequently, Wen et al [7] investigated the efficacy and tolerability of this formula on 91 patients in China with moderateto-severe asthma in a double-blind, randomized, placebo-controlled trial comparing ASHMI to oral prednisone therapy. Subjects in the ASHMI group received oral ASHMI capsules (4 capsules, tid, 0.3 g/capsule) and placebo tablets similar in appearance to prednisone.…”

Section: Anti-asthma Herbal Medicine Intervention (Ashmi)mentioning

confidence: 99%

Traditional Chinese herbal remedies for asthma and food allergy

Li¹

2007

Journal of Allergy and Clinical Immunology

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The increasing prevalence of allergic diseases in westernized countries is a significant health problem. Curative therapies for these diseases are not available. There are also significant concerns regarding the potential side effects from the chronic use of conventional drugs such as corticosteroids, especially in children. Many patients with chronic allergic conditions seek complementary and alternative medicine (CAM) therapies including traditional Chinese medicines (TCM). This trend has begun to attract interest from the mainstream healthcare providers and scientific investigators, and has stimulated government agencies in the US to provide support and guidance for the scientific investigation of CAM. This effort may lead to improved therapies and better healthcare/patient outcomes. This review presents an update on the most promising Chinese herbal remedies for asthma and food allergy.

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“…As many as 40% of patients with asthma are estimated to use herbal therapies to self-treat their asthma symptoms (6,7). The exact mechanism of action of these agents is unclear, but may involve the attenuation of allergic responses (i.e., IgE concentrations) (8), anti-inflammatory and antioxidant effects (5), or direct effects on airway smooth muscle (ASM) (9,10). Of note is the use of ginger in alleviating respiratory symptoms, dyspepsia, and gastrointestinal motility disorders (11)(12)(13).…”

mentioning

confidence: 99%

Effects of Ginger and Its Constituents on Airway Smooth Muscle Relaxation and Calcium Regulation

Townsend

Siviski

Zhang

et al. 2013

Am J Respir Cell Mol Biol

105

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The prevalence of asthma has increased in recent years, and is characterized by airway hyperresponsiveness and inflammation. Many patients report using alternative therapies to self-treat asthma symptoms as adjuncts to short-acting and long-acting b-agonists and inhaled corticosteroids (ICS). As many as 40% of patients with asthma use herbal therapies to manage asthma symptoms, often without proven efficacy or known mechanisms of action. Therefore, investigations of both the therapeutic and possible detrimental effects of isolated components of herbal treatments on the airway are important. We hypothesized that ginger and its active components induce bronchodilation by modulating intracellular calcium ([Ca 21 ] i ) in airway smooth muscle (ASM). In isolated human ASM, ginger caused significant and rapid relaxation. Four purified constituents of ginger were subsequently tested for ASM relaxant properties in both guinea pig and human tracheas: ] i regulation. These purified compounds may provide a therapeutic option alone or in combination with accepted therapeutics, including b 2 -agonists, in airway diseases such as asthma.

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Efficacy and tolerability of antiasthma herbal medicine intervention in adult patients with moderate-severe allergic asthma

Cited by 170 publications

References 32 publications

Asthma in the 21st Century — Unexpected Applications of Ancient Treatments

Asthma in the 21st Century — Unexpected Applications of Ancient Treatments

Traditional Chinese herbal remedies for asthma and food allergy

Effects of Ginger and Its Constituents on Airway Smooth Muscle Relaxation and Calcium Regulation

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