Efficacy and Safety of Vonoprazan-Amoxicillin Dual Regimen With Varying Dose and Duration for Helicobacter pylori Eradication: A Multicenter, Prospective, Randomized Study

Peng, Xiang; Yao, Jia-Yin; Ma, Yu-qian; Li, Guo-hua; Chen, Huang-wei; Wan, Yu; Liang, Dong-sheng; Zhang, Min; Zhi, Min

doi:10.1016/j.cgh.2024.01.022

Clinical Gastroenterology and Hepatology

2024

DOI: 10.1016/j.cgh.2024.01.022

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Efficacy and Safety of Vonoprazan-Amoxicillin Dual Regimen With Varying Dose and Duration for Helicobacter pylori Eradication: A Multicenter, Prospective, Randomized Study

Xiang Peng,

Jia-Yin Yao,

Yu-qian Ma

et al.

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2024

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Cited by 2 publications

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Efficacy and safety of high-dose dual therapy in eradicating Helicobacter pylori

Ye,

Zhu,

et al. 2024

WCJD

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Efficacy and safety of high-dose dual therapy in eradicating Helicobacter pylori

Ye,

Zhu,

et al. 2024

WCJD

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Comparative Efficacy and Safety of Potassium-Competitive Acid Blocker-Based Dual, Triple, and Quadruple Regimens for First-Line Helicobacter pylori Infection Treatment: A Systematic Review and Network Meta-Analysis

Rokkas,

Ekmektzoglou,

Niv

et al. 2024

Am J Gastroenterol

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BACKGROUND & AIMS: In the last few years numerous new P-CAB based RCTs concerning first-line regimens for H. pylori infection treatment from various countries have been published. However, no NWM exists which examines the comparative efficacy and safety of P-CAB based dual, triple and quadruple treatments and therefore, in this network meta-analysis (NWM) we examined this matter comparing efficacy and safety of these P-CAB based regimens. METHODS: Databases were searched for identification, screening, eligibility and inclusion of relevant randomized controlled trials (RCTs). Extracted data were entered into a Bayesian NWM and the ranking order for each regimen was evaluated by means of surfaces under cumulative ranking area (SUCRA) values. RESULTS: Twenty-five eligible RCTs were included with 7,605 patients randomized to 6 first line regimens, i.e. PCAB-DUAL, PCAB-TRIPLE, PCAB-QUADRUPLE, PPI-DUAL, PPI-TRIPLE, and PPI- QUADRUPLE. The SUCRA values (%) for these 6 regimens were 92.7, 62.5, 33.9, 75.1, 19.4 and 16.3 respectively. The comparative effectiveness ranking showed that PCAB-DUAL regimen ranked first for efficacy and last for adverse effects and had the best profile for integrated efficacy-safety. CONCLUSIONS: In this NWM concerning the comparative efficacy and safety of P-CAB based dual, triple and quadruple regimens for first line H. pylori infection treatment, the overall results showed that PCAB based dual treatment ranked first for efficacy with the best-integrated efficacy-safety profile. This is of importance, since the dual regimens overcome the crucial issue of clarithromycin resistance. Consequently, these findings are expected to be useful in helping clinical decision-making and future guidelines.

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Efficacy and Safety of Vonoprazan-Amoxicillin Dual Regimen With Varying Dose and Duration for Helicobacter pylori Eradication: A Multicenter, Prospective, Randomized Study

Cited by 2 publications

References 16 publications

Efficacy and safety of high-dose dual therapy in eradicating Helicobacter pylori

Efficacy and safety of high-dose dual therapy in eradicating Helicobacter pylori

Comparative Efficacy and Safety of Potassium-Competitive Acid Blocker-Based Dual, Triple, and Quadruple Regimens for First-Line Helicobacter pylori Infection Treatment: A Systematic Review and Network Meta-Analysis

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