Efficacy and safety of valsartan plus hydroclorothiazide for high blood pressure

Ruvolo, Antonio; Mercurio, Valentina; Fazio, Valeria; Carlomagno, Guido; Russo, Teresa; Affuso, Flora; Fazio, Serafino

doi:10.4330/wjc.v2.i5.125

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Cited by 2 publications

(1 citation statement)

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“…For cohort studies (Table S2, http://links.lww.com/HJH/ B3), the domains 'selection', 'comparability' and 'exposure' were adequate, indicating a low risk of bias. Two studies [38,42], however, constituted overall a significantly higher risk of bias, and therefore, extra attention is needed when interpreting their results.…”

Section: Risk Of Biasmentioning

confidence: 99%

Do treatment-induced changes in arterial stiffness affect left ventricular structure? A meta-analysis

Waaij

Heusinkveld²,

Delhaas³

et al. 2019

Journal of Hypertension

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Section: Risk Of Biasmentioning

confidence: 99%

Do treatment-induced changes in arterial stiffness affect left ventricular structure? A meta-analysis

Waaij

Heusinkveld²,

Delhaas³

et al. 2019

Journal of Hypertension

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show abstract

Safety and efficiency of valsartan and combination of valsartan plus hydrochlorothiazide for high blood pressure

Bunc¹

2013

Afr. J. Pharm. Pharmacol.

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The essential hypertension is one of the most common cardiovascular risk factors in adult population. The duration of hypertension influences the risk of stroke, heart failure, atherosclerosis, and kidney disease. Diuretics, beta blockers, calcium-antagonists, ACE-inhibitors, and sartans may be used to treat arterial hypertension. In this study, the efficacy and safety of a prompt pharmacologic treatment with valsartan (VAL) or combination of valsartan plus hydrochlorothiazide (VAL/HYCT) in middle aged population was demonstrate with the most frequent cardiovascular risk factors. The results of the 4 months study period showed that treatment with VAL or VAL/HYCT in middle aged 1059 patients significantly reduce the systolic and diastolic blood pressure. Average systolic and diastolic blood pressure were lowered from 161.2 (16.5) and 92.9 (9.5) mmHg to 136.1 (12.5) and 81.6 (7.8) mmHg, respectively. Side effects were observed only in few patients: elevated serum creatinine (4.6%), elevation of HbA1c (1%) and serum potassium values (0.3%). It may be concluded that VAL or VAL/HYCT is safe and very effective potent antihypertensive drug.

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Efficacy and safety of valsartan plus hydroclorothiazide for high blood pressure

Abstract: The full-dose combination of valsartan plus hydrochlorothiazide produced optimal BP control with regression of target organ damage, already after 3 mo, without relevant side effects.

Cited by 2 publications

References 22 publications

Do treatment-induced changes in arterial stiffness affect left ventricular structure? A meta-analysis

Do treatment-induced changes in arterial stiffness affect left ventricular structure? A meta-analysis

Safety and efficiency of valsartan and combination of valsartan plus hydrochlorothiazide for high blood pressure

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