Abstract:Acyclovir has well-documented efficacy and tolerability in the treatment of herpes zoster. Its limited oral bioavailability and short half-life, however, necessitates frequent dosing. Valacyclovir, the l-valyl ester of acyclovir, could be rapidly converted to acyclovir after oral administration, resulting in a three to five fold increase in acyclovir bioavailability compared with oral acyclovir in humans. The study was done in the department of Dermatology and Venereology, Faridpur Medical College Hospital (FM… Show more
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