Efficacy and Safety of Two Different n-Butyl-2-Cyanoacrylates for the Embolization of Varicoceles: A Prospective, Randomized, Blinded Study

Vanlangenhove, Peter; Keukeleire, Katrien De; Everaert, Karel; Maele, Georges Van; Defreyne, Luc

doi:10.1007/s00270-011-0188-9

Cited by 30 publications

(29 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, percutaneous embolization has the advantage of being an outpatient procedure with a faster return to normal activities, a considerably lower cost and a lower recurrence rate than is the case for surgery (6). The use of many different embolic agents, such as gelatin sponge, stainless steel coils, Amplatzer vascular plugs, detachable balloons, cyanoacrylate glues or sclerosing agents has been reported (7)(8)(9)(10)(11)(12)(13)(14)(15). However, to our knowledge, there are no data in the literature regarding the comparison of the different embolic materials currently available on the market for the treatment of varicocele in terms of efficacy, tolerance, radiation and recurrence rates.…”

Section: Introductionmentioning

confidence: 65%

“…Additional coils are then placed in the upper part of the spermatic vein, as we usually did in our study. In Europe, the main cyanoacrylate glues used for medical purposes today are NBCA (Histoacryl ® ) and NBCA-MS (Glubran ® 2), a copolymer of NBCA with a lower temperature of polymerization (10,22). The endothelium of the vessel is damaged as a result of the heat generated by the polymerization reaction of the glue.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of three different embolic materials for varicocele embolization: retrospective study of tolerance, radiation and recurrence rate

Loffroy¹,

Mourey²,

Genson³

et al. 2016

Journal of Vascular and Interventional Radiology

View full text Add to dashboard Cite

Background: To evaluate pain, radiation and recurrence rates in patients undergoing varicocele embolization with three different embolic materials.Methods: Retrospective study of 182 consecutive patients who underwent transcatheter retrograde varicocele embolization from July 2011 to May 2015 with glue (Glubran ® 2) (group 1, n=63), mechanical agents (coils and/or plugs) (group 2, n=53) or a sclerosing agent (polidocanol) (group 3, n=66). Patients were asked by telephone interview to evaluate pain during embolization and at 1, 7 and 30 days using a quantitative pain scale ranging from 0 to 10. Duration of scopy, kinetic energy released per unit mass (kerma) and dose area product (DAP) were assessed as radiation parameters during embolization procedures.Recurrence rates after treatment were also evaluated. Statistical analyses were performed using parametric and non-parametric tests.Results: Patients in the three study groups were comparable for age, clinical indication and embolization side. No difference was noted for significant pain (pain score ≥3) during embolization and at 1, 7 and 30 days after treatment. Discomfort (pain score <3) was more frequent in group 1 than in groups 2 and 3 at 7 days after the procedure (P=0.049). No difference in discomfort was noted during embolization or at 1 and 30 days. Duration of scopy was shorter (P<0.0001) and kerma was lower (P=0.0087) in group 1 than in groups 2 and 3. DAP was lower in group 1 than in group 2 (P=0.04) but no difference was noted between groups 1 and 3, and groups 2 and 3. The recurrence rate at a mean follow-up of 24.4 months (range, 2-53 months)was significantly lower in group 1 than in the two other groups (P=0.032).Conclusions: The use of Glubran ® 2 acrylic glue for varicocele embolization is safe and leads to less radiation and lower recurrence rates than is the case for other embolic materials without any more significant pain.

show abstract

Section: Introductionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Comparison of three different embolic materials for varicocele embolization: retrospective study of tolerance, radiation and recurrence rate

Loffroy¹,

Mourey²,

Genson³

et al. 2016

Journal of Vascular and Interventional Radiology

View full text Add to dashboard Cite

show abstract

“…Most studies based on venography and with large number of patients report a bilateral varicocele in 25% [8][9][10]. In studies using different diagnostic tools, bilateral varicocele was reported in a range between 40% and 60% [11][12].…”

Section: Presentation Incidence and Epidemiology Of Varicocelesmentioning

confidence: 99%

“…Only embolization with high viscosity liquids (glue) has a reported low technical failure rate (<1%) and lower recurrence rates (< 2%) [10,23,36,37]. The low technical failure rate is probably related to the use of a coaxial catheter system.…”

Section: Non-liquid Embolicsmentioning

confidence: 99%

See 1 more Smart Citation

Contribution to the Pathophysiology and Treatment of Varicoceles

Vanlangenhove¹

2018

Journal of the Belgian Society of Radiology

Self Cite

View full text Add to dashboard Cite

Anatomical differences between adults and adolescents and between left and right varicoceles were shown in this work. We designed a standardized and reproducible method for pressure measurement in the inguinal internal spermatic vein (ISV). We demonstrated that the mean absolute pressure in the ISV in the upright position is higher than the veno-capillary pressure in the testicle, and hence could impair spermatogenesis prompting the need for treatment in varicoceles.Histoacryl transparent and Glubran2, the current commercially available adhesives for the treatment of varicoceles, do not differ with regard to efficiency, safety and tolerance during and after embolization. Both adhesives cause a mild pain in 30% of the patients in the week after embolization. The radiation exposure is low during embolizations of varicoceles with highly viscous liquid products. Therefore, the endovascular treatment with glue is an efficient, safe and tolerable method of treatment for varicoceles when applicable. Keywords: Varicocele; Embolization; Glue IntroductionThis thesis aimed at contributing to the pathophysiology and treatment of varicoceles. The research project encompasses five prospective studies and one retrospective study. The specific objectives of these clinical studies were to assess: (i) the safety, efficacy and tolerance of two types of glue and a non-gluing liquid embolic agent, in the endovascular treatment of varicoceles, (ii) to assess radiation burden for patient during varicocele embolization, (iii) to develop a standardized method to read the phlebographic anatomy of varicoceles and to test a different ontogenesis of varicoceles in adolescents and adults, and (iv) lastly to develop a standardized method to measure the intravascular pressure in the internal spermatic vein and to determine whether infertility in varicoceles can be explained by the principle of elevated hydrostatic pressure.

show abstract

Surgical or radiological treatment for varicoceles in subfertile men

Persad

O'Loughlin

Kaur

et al. 2021

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Efficacy and Safety of Two Different n-Butyl-2-Cyanoacrylates for the Embolization of Varicoceles: A Prospective, Randomized, Blinded Study

Abstract: NBCA and NBCA-MS are equally efficient and safe glues for embolization of varicoceles.

Cited by 30 publications

References 28 publications

Comparison of three different embolic materials for varicocele embolization: retrospective study of tolerance, radiation and recurrence rate

Comparison of three different embolic materials for varicocele embolization: retrospective study of tolerance, radiation and recurrence rate

Contribution to the Pathophysiology and Treatment of Varicoceles

Surgical or radiological treatment for varicoceles in subfertile men

Contact Info

Product

Resources

About