Efficacy and Safety of Triple Antihypertensive Therapy with the Olmesartan/Amlodipine/Hydrochlorothiazide Combination

Abstract

Registered at ClinicalTrials.gov identifier as NCT00923091.

Efficacy and Tolerability of Triple‐Combination Therapy With Olmesartan, Amlodipine, and Hydrochlorothiazide: A Subgroup Analysis of Patients Stratified by Hypertension Severity, Age, Sex, and Obesity

“…16 The study consisted of a double-blind safety run-in (weeks 0-2: period I), double-blind (weeks 3-10: period II), single-blind (weeks [10][11][12][13][14][15][16][17][18], and open-label treatment periods (weeks 18-54). The single-blind and open-label treatment periods are beyond the focus of the current report and are not described here.…”

“…In addition, a factorial study in patients with moderate to severe hypertension investigated the addition of HCTZ 12.5 mg and 25 mg to OLM/AML treatment and found it provided statistically significant improvements in BP reduction and achievement of BP thresholds (ClinicalTrials.gov identifier: NCT00923091). 16 This multinational, phase III, randomized, double-blind study provides an opportunity to assess the efficacy of triple-combination therapy in higher-risk subgroups of hypertensive patients, including those with severe hypertension and other risk factors.…”

“…16 The ability of this triple-combination therapy to lower BP in patients with a range of elevated BP levels was also investigated in a post-hoc analysis of the hypertension severity profile of patients in the triple OLM/AML/HCTZ therapy compared with dual OLM/ AML therapy groups. In addition, to obtain insights into the efficacy of triple-combination therapy in other important groups of hypertensive patients, prespecified analyses of the efficacy and safety of adding HCTZ to OLM/AML were performed in subgroups defined by baseline age, sex, and obesity status.…”

Educational Interventions May Promote Better Blood Pressure Control in Russia

“…Information obtained from these analyses are of potential clinical relevance, since they can be effectively implemented by recommendations derived from international guidelines, in order to improve the clinical management and achieve the recommended blood pressure targets. In particular, recent studies have demonstrated that the implementation of rational and effective therapeutic regimes, mostly based on combination therapies, may promote higher rates of blood pressure control also in the setting of real practice [5][6][7].In this issue of High Blood Pressure and Cardiovascular Prevention, Kiselev and co-authors reported a detailed and comprehensive analysis of clinical factors that may have potential impact on the achievement of the blood pressure goals in a large sample of adult individuals with hypertension in the Ivanovo, Russia [8]. This study is part of the larger Russian Registry of Hypertension, Coronary Artery Disease and Chronic Heart Failure, which is a retrospective, continuous, nation-wide, web-based registry.…”

“…Information obtained from these analyses are of potential clinical relevance, since they can be effectively implemented by recommendations derived from international guidelines, in order to improve the clinical management and achieve the recommended blood pressure targets. In particular, recent studies have demonstrated that the implementation of rational and effective therapeutic regimes, mostly based on combination therapies, may promote higher rates of blood pressure control also in the setting of real practice [5][6][7].…”