Efficacy and Safety of Tranexamic Acid for the Control of Surgical Bleeding in Patients Under Liposuction

Rodríguez-García, F A; Sánchez-Peña, M A; Andrea, Gjergj; Villarreal-Salgado, José Luis; Álvarez-Trejo, H J; Medina-Quintana, V M; García-Valenzuela, Salvador Eloy; Morfin-Meza, Karen; Fierro-Rodríguez, Diego Armando; Dorado-Hernández, Emmanuel; Bonilla-Catalán, Pablo Valente; Ramos-Maciel, Joel; Romero-Algara, Enrique; Jiménez-Pavón, K E; Torres-Salazar, Quitzia Libertad

doi:10.1007/s00266-021-02486-y

Cited by 10 publications

(12 citation statements)

References 26 publications

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“…17 Rodriguez-Garcia and Sanchez-Peña also found less bleeding in the group in which TXA was used in the tumescent infusion before liposuction than in the group in which it was not used. 20 In previous studies, we had found the efficiency of the use of 1 g of IV TXA half an hour before the start of body contouring surgery, where blood loss had been less in the group where TXA was used compared with the control group where TXA was not used. 17 However, considering that bleeding persists after body contouring surgical procedures, because the area worked on is wide, and wide detachments, it was decided to carry out this study, the main premise of which was to extend the use of TXA up to 48 hours after surgery.…”

Section: Discussionmentioning

confidence: 92%

“…5 Although TXA is a product widely used in various areas of medicine and surgery, [6][7][8][9][10][11][12] only recently has it been used in different surgical procedures in the field of plastic surgery, [13][14][15][16] including body contouring surgery. [17][18][19][20] The usefulness of TXA has already been determined during liposuction, in different forms and processes with very good results. [17][18][19][20] However, there is no comparative study that evaluates the effect and possible benefits of continuing its administration for 48 hours after surgery.…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19][20] The usefulness of TXA has already been determined during liposuction, in different forms and processes with very good results. [17][18][19][20] However, there is no comparative study that evaluates the effect and possible benefits of continuing its administration for 48 hours after surgery. That is why we developed a comparative protocol using it in the transoperative period and continuing its use during the immediate postsurgical period to find out the benefits provided by this scheme and to evaluate possible complications, with the aim of reducing bleeding and the amount of blood transfusions.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial

Bayter-Marín,

Hoyos,

Cárdenas-Camarena

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Background: Tranexamic acid (TXA) is used to reduce bleeding in body contouring procedures; however, there are no studies that show the effectiveness of TXA when it is also used in the immediate postoperative period. Methods: A controlled, randomized, parallel, and open-label clinical trial was carried out in adult patients undergoing liposculpture and/or abdominoplasty. A control group administering presurgical TXA and a study group with presurgical and postsurgical TXA were formed. The decrease in hemoglobin and the incidence of blood transfusions between both groups were compared as well as the possible adverse effects of TXA. Results: Four hundred twenty-seven subjects were included, 208 (48.7%) in the control group and 219 (51.3%) in the study group. The median age was 34 years (interquartile range 28–42). Median postoperative hemoglobin levels at 24 hours were similar in both groups (study 11.3 g/dL versus control 11.1 g/dL, P = 0.07); however, at 72 hours, postoperative hemoglobin was higher in the study group versus control (10.8 versus 10.0 g/dL, P ≤ 0.001). The incidence of transfusions at 72 hours was 1.8% in the study group and 8.6% in the control group, for a risk ratio of 0.21 (95% confidence interval 0.07–0.61). There were no adverse or thromboembolic events. Conclusion: TXA proved to be more effective in reducing intra- and postsurgical bleeding and the need for transfusions, when used preoperatively and continued for 48 hours after surgery, than when used only preoperatively, without reporting adverse or thromboembolic effects.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial

Bayter-Marín,

Hoyos,

Cárdenas-Camarena

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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“…Normally, fibrinogen binds to lysine binding sites on fibrin molecules and is converted to fibrinogenase in the presence of tissue plasminogen activator [45]. TXA blocks activation of plasminogen and prevents binding of plasmin to fibrin [46].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of tranexamic acid in intracranial haemorrhage: A meta-analysis

et al. 2023

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Background Although some studies have shown that tranexamic acid is beneficial to patients with intracranial haemorrhage, the efficacy and safety of tranexamic acid for intracranial haemorrhage remain controversial. Method The PubMed, EMBASE, and Cochrane Library databases were systematically searched. The review followed PRISMA guidelines. Data were analyzed using the random-effects model. Results Twenty-five randomized controlled trials were included. Tranexamic acid significantly inhibited hematoma growth in intracranial hemorrhage (ICH) and traumatic brain injury (TBI) patients. (ICH: mean difference -1.76, 95%CI -2.78 to -0.79, I2 = 0%, P < .001; TBI: MD -4.82, 95%CI -8.06 to -1.58, I2 = 0%, P = .004). For subarachnoid hemorrhage (SAH) patients, it significantly decreased the risk of hydrocephalus (OR 1.23, 95%CI 1.01 to 1.50, I2 = 0%, P = .04) and rebleeding (OR, 0.52, 95%CI 0.35 to 0.79, I2 = 56% P = .002). There was no significance in modified Rankin Scale, Glasgow Outcome Scale 3–5, mortality, deep vein thrombosis, pulmonary embolism, or ischemic stroke/transient ischemic. Conclusion Tranexamic acid can significantly reduce the risk of intracranial haemorrhage growth in patients with ICH and TBI. Tranexamic acid can reduce the incidence of complications (hydrocephalus, rebleeding) in patients with SAH, which can indirectly improve the quality of life of patients with intracranial haemorrhage.

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“… 2 While topical TXA has been shown to improve ecchymosis in fat graft donor sites in a retrospective study and to reduce decreases in hematocrit and need for transfusion in abdominal liposuction in a prospective study, it would be of interest to validate these results in a prospective split-breast study. 3 , 4 …”

mentioning

confidence: 99%

Considerations for Differentiating the Effects of Intravenous and Topical Tranexamic Acid in Liposuction in Future Research Protocols

Stoehr

Fine

2021

Aesthetic Surgery Journal Open Forum

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Efficacy and Safety of Tranexamic Acid for the Control of Surgical Bleeding in Patients Under Liposuction

Cited by 10 publications

References 26 publications

Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial

Effectiveness of Tranexamic Acid in the Postoperative Period in Body Contour Surgery: Randomized Clinical Trial

Efficacy and safety of tranexamic acid in intracranial haemorrhage: A meta-analysis

Considerations for Differentiating the Effects of Intravenous and Topical Tranexamic Acid in Liposuction in Future Research Protocols

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