Efficacy and Safety of Topiramate in the Treatment of Obese Subjects With Essential Hypertension

Weight Management in Type 2 Diabetes: Current and Emerging Approaches to Treatment

“…Topiramate has several pharmacological mechanisms of action and has been assessed as a single agent for weight reduction in obese patients with and without type 2 diabetes and hypertension (81)(82)(83).…”

Cannabinoid-1 Receptor Antagonist, Rimonabant, for Management of Obesity and Related Risks

“…Although some of the drugs indicated for other conditions-bupropion, topiramate, and zonisamide, to name a few-have been studied for the treatment of obesity with positive results, these findings have limitations, because most of these trials have not examined large samples for long durations. 28 -35 Topiramate has consistently been shown to be effective for weight reduction, with notable improvements in BP and hemoglobin A 1C (HbA 1C ), but neuropsychiatric adverse events, which occur at high frequency, [32][33][34][35] limit its usefulness as an antiobesity drug. Numerous drug candidates for obesity treatment have fizzled in the past few years because of safety concerns or lack of efficacy in phase II or III trials.…”

Gewichtsveränderungen unter Antiepileptikagabe

“…Ein Einfluss der Dosis auf die Gewichtsabnahme scheint vorzuliegen [37][40] [43] [48], auch wenn sich in einigen Studien kein solcher Effekt zeigte [36] [42]. Möglicherweise kommt es erst im oberen Dosisbereich zu einer vermehrten Gewichtsreduktion [42].…”