Efficacy and safety of the ab interno gelatin stent in severe pseudoexfoliation glaucoma compared to non-pseudoexfoliation glaucoma at 6 months

Dar, Nimrod; Sharon, Tal; Hecht, Idan; Kalev-Landoy, Maya; Burgansky-Eliash, Zvia

doi:10.1177/1120672119848277

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…As a result, PEG exhibited a better survival rate than did POAG in both multivariate (Table 2) and univariate (Fig 3) analyses. This is in an agreement with previous studies reporting favorable clinical results of other MIGS procedures in patients with PEG [38,39]. PEG is a common cause of secondary glaucoma and it is reportedly frequent in many populations [40][41][42][43][44].…”

Section: Plos Onesupporting

confidence: 93%

Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma

et al. 2021

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The purpose of the study was to evaluate the 12-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy. The changes in the intraocular pressure (IOP) and medication score and the success rate of the surgery were analyzed. Thirty-four eyes of 29 patients with primary open-angle glaucoma (POAG; n = 16) or pseudoexfoliation glaucoma (PEG; n = 18) with a 12-month follow-up period were included in the study. The decreases in IOP and medication score from the baseline to the all-time-point were statistically significant (P < 0.001). The surgical success rates were 97.1%, 76.5%, and 44.0% at 3 months (90 days), 6 months (180 days), and 12 months (365 days), respectively. A mixed effect Cox model revealed that the type of glaucoma (POAG) was significantly associated with surgical failure (P = 0.044). Furthermore, the surgical success rate was significantly higher in eyes with PEG than it was in those with POAG (P = 0.019). Stand-alone ab interno trabeculotomy significantly lowered both the IOP and the medication score in patients with glaucoma, although almost one quarter of the cases needed additional glaucoma surgeries. The surgical success rate was significantly higher in eyes with PEG than it was in those with POAG.

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Section: Plos Onesupporting

confidence: 93%

Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma

et al. 2021

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“…Among 14 studies using an absolute dose of 10 µg, the weighted mean average IOP was reduced from 24.4 mm Hg on 2.7 medications at baseline to 15.2 mm Hg on 0.7 medications at the end of follow-up. 5,24,26,[28][29][30][32][33][34][35][36]89,104 Among 21 studies using an absolute dose of 20 µg, the weighted mean average IOP was reduced from 21.6 mm Hg on 2.7 medications at baseline to 14.4 mm Hg on 0.8 medications at the end of follow-up. 5,10,15,21,24,28,33,34,[44][45][46][47][48]50,[54][55][56]60,63,65,68 Only two studies were available with a calculated mean dose of 40 µg; due to the paucity of data, these data are not shown.…”

Section: Interpretationsmentioning

confidence: 99%

“…88 A limited number of studies reported outcomes among eyes diagnosed with POAG compared to PEXG (Table 7). 11,22,36,89,90 Similarly, data are limited but nonetheless encouraging in the setting of uveitic glaucoma. Qureshi et al reported outcomes in an observational case series of 37 eyes with medically uncontrolled glaucoma secondary to uveitis.…”

Section: Interpretationsmentioning

confidence: 99%

Intraocular Pressure and Medication Changes Associated with Xen Gel Stent: A Systematic Review of the Literature

Panarelli¹,

Vera²,

Sheybani³

et al. 2023

OPTH

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The Xen gel stent (Allergan Inc, an AbbVie company; Dublin, Ireland) was conceived as an option for patients requiring modest IOP reduction but for whom trabeculectomy was not yet indicated. As with any glaucoma surgery, establishing criteria for patient selection and identifying factors that contribute to a high likelihood of success are important. To help guide clinical decisionmaking, a systematic review of published studies on the gel stent was performed, with the goal of understanding postoperative outcomes based on clinical and patient factors. Results were organized around a series of pertinent clinical questions based on scenarios encountered in clinical practice. Criteria for including studies were intentionally broad, with the objective of simulating the diverse population of glaucoma patients encountered in real-world practice. Outcomes for IOP and medication reduction postoperatively were assessed in various analyses, including in eyes with various glaucoma types and severity; in eyes naïve to surgery as well as those with a history of prior incisional glaucoma surgery; and when surgery was performed as a standalone procedure or at the time of cataract surgery. The results of each of the various analyses were consistent in demonstrating that successful gel stent surgery achieved a postoperative IOP of approximately 14.0 mm Hg and reduction to fewer than 1 glaucoma medication. Additional data are shown on outcomes by method of implant (ab interno vs ab externo); intraoperative use of antifibrotics; and rates of needling in published studies.

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“…Multiple recent series have demonstrated the safety and efficacy of XEN gel stent placement at the time of cataract surgery in reducing IOP and IOP lowering medication [35][36][37][38][39][40][41][42]. Interestingly, Widder et al reported that pseudophakic eyes had the most favorable primary success rate compared to phakic eyes and combined surgery with phacoemulsification, and this finding influenced their clinical decision making so as to no longer offer patients combined surgery [43].…”

Section: It Is the Only Currently Available Subconjunctival Migs Devimentioning

confidence: 99%

An Update on Microinvasive Glaucoma Surgery Concurrent With Cataract Extraction

Tassel

Chen

2019

Curr Ophthalmol Rep

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Purpose of Review In this article, we review the current options for microinvasive glaucoma surgery (MIGS) combined with cataract extraction in the USA and the efficacy of the various approaches. Recent Findings MIGS is a rapidly growing area of research and clinical interest. Available surgeries aim to reduce intraocular pressure by improving aqueous outflow through the trabecular or subconjunctival pathways or by reducing aqueous production. Summary Multiple approaches to MIGS are utilized in clinical practice. On average, these surgeries are safe and modestly effective in reducing intraocular pressure. Future research will demonstrate which surgical approaches are most efficacious, whether and how to combine MIGS, and the role of MIGS in improving patient quality of life.

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Efficacy and safety of the ab interno gelatin stent in severe pseudoexfoliation glaucoma compared to non-pseudoexfoliation glaucoma at 6 months

Cited by 6 publications

References 22 publications

Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma

Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma

Intraocular Pressure and Medication Changes Associated with Xen Gel Stent: A Systematic Review of the Literature

An Update on Microinvasive Glaucoma Surgery Concurrent With Cataract Extraction

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