Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections

Abstract

Background and Aims. To establish the efficacy and safety of ilaprazole, levofloxacin, and amoxicillin as a first-line eradication treatment for Helicobacter pylori. Methods. Patients with gastric ulcer, duodenal ulcer, or gastritis, as detected by esophagogastroduodenoscopy with confirmed H. pylori infection between September 2014 and November 2015, were enrolled in the study. All participants received ilaprazole (10 mg bid), levofloxacin (500 mg bid), and amoxicillin (1000 mg bid) for 10 days. H. pylori eradication was confirmed by a 13C-urea breath test at 6–8 weeks after the end of treatment. Results. Of 84 patients included in the analysis, the eradication rate was 88.8% in the per protocol group (n = 80). Demographic factors such as age, gender, body mass index (BMI), alcohol, smoking, hypertension, diabetes mellitus, and peptic ulcer did not affect the eradication rate. However, multivariate analysis showed that overweight patients and patients with cerebrovascular accident (CVA) had a significantly lower eradication rate than patients with normal BMI and without CVA. Laboratory test results did not change significantly after treatment. A total of six (7.5%) patients developed eight adverse reactions. Conclusions. A 10-day triple therapy containing ilaprazole, levofloxacin, and amoxicillin is a safe alternative first-line eradication treatment for H. pylori.

Treatment of Helicobacter pylori infection in 2018

“…A review of levofloxacin‐based third‐line therapy over the past decade in Korea found pooled eradication rates of 71.6% throughout the decade, suggesting no increase in resistance rates over the past decade . A 10‐day triple therapy containing ilaprazole, levofloxacin, and amoxicillin reported good results, with an eradication rate of 88.8% …”

“…41 A 10-day triple therapy containing ilaprazole, levofloxacin, and amoxicillin reported good results, with an eradication rate of 88.8%. 42…”

Diagnosis of Helicobacter pylori infection

“…In addition, Suki et al demonstrated a positive association between H. pylori infection and increased BMI (especially in patient groups with obesity). Furthermore, high BMI and stroke were associated with unsuccessful eradication, using 13 C‐UBT at 6‐8 weeks after initiation of therapy …”

“…Furthermore, high BMI and stroke were associated with unsuccessful eradication, using 13 C-UBT at 6-8 weeks after initiation of therapy. 22…”

The efficacy, safety, and tolerability of levofloxacin quadruple therapy for helicobacter pylori eradication: a randomized, double-blind clinical trial

“…The e cacy of present pharmacological treatments for H. pylori infection has evaluated in different studies [8][9][10][11][12][13][14]. The co-administration of a proton-pump inhibitor (PPI) and two antibiotics (triple therapy), or addition of bismuth salts to the triple therapy (bismuth-based quadruple therapy) for a period of 14 A block randomization method was used in order to assign patients randomly into permuted treatment blocks and ensure equal numbers in each group of treatment.…”