Efficacy and safety of the 2% formulation of testosterone topical solution applied to the axillae in androgen-deficient men

Abstract

These results indicate that once-daily application of the testosterone topical solution 2% to the axillae is a safe and effective treatment for androgen replacement in hypogonadal men.

Phase 1 pharmacokinetics and phase 3 efficacy of testosterone nasal gel in subjects with seasonal allergies

“…11,24,25,26 Fifty-eight patients with prior medical history of AR were Baseline characteristics and treatment outcomes for AR and non-AR patients completing the 90-day treatment period are very similar (Table 6). Hypogonadal patients with AR had a mean starting testosterone level of 250 ng/dL compared to 229 for non-AR patients.…”

Transdermal delivery of testosterone

“…In pilot studies application of the formulation to the axillary region resulted in higher serum testosterone concentrations compared with application to the inner forearm. An open label study conducted over 120 days evaluated the pharmacokinetics and efficacy of the formulation (56). Patients used a pump-actuated device to apply the formulation (30 mg testosterone per 1.5 ml) with a starting dose of 60 mg of drug.…”

Androgens

“…One patch [6] and several gels [7][8][9][10] are currently marketed. The patch causes severe skin rash in about one-third of users, but the gels rarely do.…”