Efficacy and safety of terbinafine hydrochloride 1% cream vs eberconazole nitrate 1% cream in localised tinea corporis and tinea cruris

Choudhary, Sanjiv; Aghi, Taru; Bisati, Shazia

doi:10.4103/2229-5178.131079

Cited by 13 publications

(10 citation statements)

References 7 publications

(6 reference statements)

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“…8 Eberconazole is clinically effective in the treatment of topical fungal infections, with good safety profile and tolerability. 9,10 In our study, all three topical drugs were well tolerated and found to be safe. Local side effects such as erythema, swelling, stinging sensation, or itching as mentioned in a few studies were not reported.…”

Section: Discussionmentioning

confidence: 50%

Evaluation of newer imidazoles in dermatophytosis

et al. 2019

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Background: Eberconazole, a newer Imidazole derivative, antimycotic drug. Similarly, sertaconazole and luliconazole are also newer antifungal which all exhibit fungicidal, fungistatic and anti-inflammatory actions. But, sertaconazole in addition have antipruritic effect also.Methods: Randomized, open-labelled, prospective study comprising of 75 patients divided into three equal groups A, B, C of 25 patients each. Group A received eberconazole 1%, Group B received sertaconazole 2% and Group C received luliconazole 1% for twice daily topical application for 4 weeks. Patients were asked to review at 2nd and 4th week to record clinical and mycological cure.Results: In this study out of 75, seventy patients completed the complete course of treatment whereas, five patients were not reported for review citing personal reasons. Parameters included are pruritus, erythema, scaling and vesicles in all three groups. In this study, marked relief of pruritus was achieved clinically with eberconazole (72.7%) followed by luliconazole and sertaconazole with 50.0% and 33.3% respectively at 4th week of treatment phase and reduction of scaling was achieved more with eberconazole (90.9%), sertaconazole (87.5%) and luliconazole (83.3%). All three groups of patients showed successful mycological cure by confirming with negative 10% potassium hydroxide examination at the end of treatment course.Conclusions: Eberconazole 1% cream was better than sertaconazole 2% cream and luliconazole 1% cream in relieving symptoms like pruritus and scaling at the end of treatment phase and follow up.

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Section: Discussionmentioning

confidence: 50%

Evaluation of newer imidazoles in dermatophytosis

et al. 2019

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“…In another study done by Choudhary et al ,[ 7 ] patients with tinea corporis and tinea cruris were treated with topical 1% terbinafine hydrochloride and 1% eberconazole nitrate cream respectively, twice daily for 3 weeks. There was 100% cure rate in both groups at the end of 3 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…A similar study comparing the efficacy and safety of eberconazole versus terbinafine had already been done on patients with tinea corporis and tinea cruris. [ 7 ] The present study was undertaken to compare the efficacy and safety of eberconazole versus terbinafine in TV.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of efficacy and safety of eberconazole versus terbinafine in patients of tinea versicolor

2018

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Background:Tinea versicolor (TV) is characterised by the appearance of maculosquamous lesions sometimes associated with mild erythema and pruritus in characteristic areas of the body. Eberconazole and terbinafine though drugs of different classes provide both mycological and clinical cure.Aim:This study aims to compare the efficacy and safety of eberconazole versus terbinafine in patients of TV.Materials and Methods:An open-label, randomised, comparative clinical trial was conducted on 60 patients. The patients were randomly divided into two study groups. Group A: Eberconazole 1% cream once daily and Group B: Terbinafine 1% cream once daily for 2 weeks. Efficacy assessment was done by observing signs and symptoms, i.e., Physician assessment 4-point scale, microscopic KOH examination, Wood's lamp examination, global clinical response assessment, and patient's assessment on visual analog scale at the end of 2 weeks and subsequently patients were reassessed at the end of 4 and 8 weeks to check any relapse. Safety assessment was also done.Results:There was a significant improvement in all the parameters in both groups over a period of 2 weeks. Both the treatment groups, i.e., eberconazole and terbinafine were found to be safe and efficacious at the end of 2 weeks, and no statistically significant difference was observed between the two groups regarding complete cure, i.e., mycological and clinical cure (80% vs. 63.33%), respectively. However, early response (at the end of week 1) was observed with eberconazole. No relapse was seen with eberconazole, but one patient had relapse at 8 weeks with terbinafine. Both drugs had similar safety profile.Conclusion:Although both the drugs cured the disease, eberconazole showed better response as clinical cure and mycological cure were observed earlier and no patient relapsed in the follow-up.

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“…Recently, a randomized control trial found similar efficacy and tolerability of 1% terbinafine cream to 1% eberconazole nitrate cream in the management of localized tinea corporis and cruris. [ 24 ] Similarly, another RCT found an efficacy of 1% terbinafine cream similar to 2% sertaconazole cream. [ 33 ] Various newer formulations, i.e., TBF-loaded liposome film, TBF-loaded liposome and ethosome, TBF-loaded transferosome, liposome poloxamer gel, microemulsion-based gel, and ethosome chitosan gel are in the developmental phase to increased penetration leading to augmented efficacy.…”

Section: Other Newer 14α-lanosterol Demethylase Inhibitorsmentioning

confidence: 97%

“…[ 23 ] A randomized controlled trial found the efficacy and safety of 1% eberconazole nitrate cream similar to that of 1% terbinafine hydrochloride cream in the treatment of localized (<20% involvement) tinea corporis and tinea cruris. [ 24 ] Recently, a study used ethyl cellulose microsponges as topical carriers of eberconazole nitrate and found four-fold higher retention of eberconazole nitrate in the stratum corneum layer compared with commercial cream,[ 25 ] which might lead to increased efficacy of the drug.…”

Section: Role Of Topical Antifungalsmentioning

confidence: 99%