Efficacy and safety of systemic tranexamic acid administration in total knee arthroplasty: A case series

Maalouly, Joseph; Assaad, Donna El; Ayoubi, Rami; Darwish, M.A.; Aouad, Dany; Lati, Georgio; Rassi, George El

doi:10.1016/j.ijscr.2020.06.077

Cited by 2 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Temporomandibular joint (TMJ) replacement surgeries are often associated with significant intraoperative blood loss (up to 1 liter of blood volume) and often require blood transfusion [ 1 , 2 ]. Intraoperative bleeding during total TMJ replacements can occur due to the proximity of major vessels such as the maxillary artery, temporal artery, and facial artery [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Tranexamic Acid Use Intra-Operatively Decreases the Need for Blood Transfusions and Post-Operative Edema in Temporomandibular Joint Surgeries

Entezari¹,

Wolford²,

Gunn³

et al. 2022

Cureus

View full text Add to dashboard Cite

Temporomandibular joint (TMJ) surgeries cover a vast assortment of surgical procedures such as tooth extractions, tissue biopsies, and extensive maxillofacial surgeries. Major complications that occur during and after TMJ surgeries include uncontrolled bleeding, considerable blood loss, serious infections, and edema. Tranexamic acid (TXA) is an antifibrinolytic agent that reduces blood loss by inhibiting the enzymatic breakdown of fibrin. Currently, TXA is widely used in various orthopedic surgeries to reduce bleeding and decrease the need for blood transfusions. In this study, we observed five patients undergoing major TMJ replacement surgeries and administered TXA during the procedure. The principal aim of this study was to examine the association between TXA administration during TMJ replacement surgery and blood loss and tissue edema.

show abstract

Section: Introductionmentioning

confidence: 99%

Tranexamic Acid Use Intra-Operatively Decreases the Need for Blood Transfusions and Post-Operative Edema in Temporomandibular Joint Surgeries

Entezari¹,

Wolford²,

Gunn³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

The Impact of Tranexamic Acid on Blood Loss Management in Primary Total Knee Arthroplasty: A Comprehensive Review

Sawant,

Deshpande,

Wamborikar

et al. 2024

Cureus

View full text Add to dashboard Cite

Total knee arthroplasty (TKA) is a widely performed surgical procedure to restore function and relieve pain in patients with advanced knee arthritis. One of the key challenges in TKA is managing perioperative blood loss, which can lead to complications such as postoperative anemia and the need for blood transfusions. Tranexamic acid (TXA), an antifibrinolytic agent, has shown promising results in reducing blood loss and transfusion requirements in various surgical settings, including TKA. This comprehensive review synthesizes current evidence regarding the efficacy and safety profile of TXA in primary TKA. Mechanistically, TXA functions by inhibiting the breakdown of fibrin clots, promoting hemostasis, and minimizing blood loss. Clinical studies evaluating TXA in TKA have consistently demonstrated significant reductions in blood loss parameters, including total blood loss, postoperative drain output, and transfusion rates. Key findings highlight the efficacy of TXA across different dosing regimens and administration routes, with minimal associated risks of thromboembolic events or adverse effects. Comparative analyses with other blood conservation strategies underscore TXA's superiority in reducing transfusion requirements and its cost-effectiveness in clinical practice. The review also discusses current clinical guidelines and recommendations for TXA use in TKA, emphasizing optimal dosing strategies and patient selection criteria. Future research directions include exploring the long-term outcomes of TXA administration and its impact on functional recovery, and refining protocols to enhance its efficacy and safety further. In conclusion, TXA represents a valuable adjunct in blood loss management during primary TKA, offering substantial benefits in patient outcomes, healthcare resource utilization, and cost-effectiveness. Continued research efforts are warranted to optimize its use and expand its applicability in orthopedic surgery.

show abstract

Efficacy and safety of systemic tranexamic acid administration in total knee arthroplasty: A case series

Cited by 2 publications

References 33 publications

Tranexamic Acid Use Intra-Operatively Decreases the Need for Blood Transfusions and Post-Operative Edema in Temporomandibular Joint Surgeries

Tranexamic Acid Use Intra-Operatively Decreases the Need for Blood Transfusions and Post-Operative Edema in Temporomandibular Joint Surgeries

The Impact of Tranexamic Acid on Blood Loss Management in Primary Total Knee Arthroplasty: A Comprehensive Review

Contact Info

Product

Resources

About