Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated systematic review and meta-analysis

Zhou, Sheng; Hu, Haiying; Ru, J. Alexander de

doi:10.1016/j.heliyon.2023.e18356

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e18356

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Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated systematic review and meta-analysis

Sheng Zhou

Haiying Hu²,

J. Alexander de Ru

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2024

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Cited by 1 publication

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Sugammadex vs Neostigmine, a Comparison in Reversing Neuromuscular Blockade: A Narrative Review

Maqusood,

Bele,

Verma

et al. 2024

Cureus

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The use of neuromuscular blocking agents (NMBA) has grown due to the development of laparoscopic and minimally invasive procedures. Respiratory insufficiency, an elevated risk of aspiration, postoperative pulmonary complications, and subsequent reintubation are among the risks linked to the residual block. The normal clinical practice calls for the pharmacologic "reversal" of these agents with either sugammadex or neostigmine prior to extubation. The administration of neostigmine is linked to a number of potential complications. In response, anaesthesiologists have begun to prescribe sugammadex more frequently for treating residual block and reversing blockade with NMBA. This review article compares and assesses neostigmine and sugammadex thoroughly in order to determine the extent to which they work as agents to reverse neuromuscular blockade. The review's findings highlight sugammadex's considerable advantages -Sugammadex's ability to quickly and reliably achieve desired train-of-four (TOF) ratios -over neostigmine in reversing neuromuscular blockade in a variety of surgical settings. In contrast, neostigmine's limitations regarding efficacy and rate of reversal were consistently noted in all of the reviewed studies, despite the fact that it is still widely used due to its lower cost and extensive clinical experience. Sugammadex is a superior option for reversing neuromuscular blockade, but incorporating it into standard clinical practice necessitates carefully weighing its potential benefits and drawbacks. Sugammadex provides notable benefits over neostigmine in terms of speed, predictability, and safety.

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Sugammadex vs Neostigmine, a Comparison in Reversing Neuromuscular Blockade: A Narrative Review

Maqusood,

Bele,

Verma

et al. 2024

Cureus

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Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated systematic review and meta-analysis

Cited by 1 publication

References 40 publications

Sugammadex vs Neostigmine, a Comparison in Reversing Neuromuscular Blockade: A Narrative Review

Sugammadex vs Neostigmine, a Comparison in Reversing Neuromuscular Blockade: A Narrative Review

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