Efficacy and safety of stem cell therapy in cerebral palsy: A systematic review and meta-analysis

Qu, Jiayang; Zhou, Lin; Zhang, Hao; Han, Dongmiao; Luo, Yaolin; Chen, Junming; Li, Lincai; Zou, Zhengwei; He, Zhengyi; Zhang, Min-Hong; Ye, Junsong

doi:10.3389/fbioe.2022.1006845

Cited by 4 publications

(3 citation statements)

References 55 publications

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“…MSCs are capable of directly differentiating into tissue cells in a particular microenvironment, thus replacing the injured cells [ 58 ]. Meanwhile, the fate of MSCs is regulated by a wide range of instructive signals from the microenvironment, which consists of many biomolecules (soluble and insoluble) and biomechanical forces [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of mesenchymal stem cell therapy in liver cirrhosis: a systematic review and meta-analysis

Lu,

Qu,

Yan

et al. 2023

Stem Cell Res Ther

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Aim Although the efficacy and safety of mesenchymal stem cell therapy for liver cirrhosis have been demonstrated in several studies. Clinical cases of mesenchymal stem cell therapy for patients with liver cirrhosis are limited and these studies lack the consistency of treatment effects. This article aimed to systematically investigate the efficacy and safety of mesenchymal stem cells in the treatment of liver cirrhosis. Method The data source included PubMed/Medline, Web of Science, EMBASE, and Cochrane Library, from inception to May 2023. Literature was screened by the PICOS principle, followed by literature quality evaluation to assess the risk of bias. Finally, the data from each study's outcome indicators were extracted for a combined analysis. Outcome indicators of the assessment included liver functions and adverse events. Statistical analysis was performed using Review Manager 5.4. Results A total of 11 clinical trials met the selection criteria. The pooled analysis' findings demonstrated that both primary and secondary indicators had improved. Compared to the control group, infusion of mesenchymal stem cells significantly increased ALB levels in 2 weeks, 1 month, 3 months, and 6 months, and significantly decreased MELD score in 1 month, 2 months, and 6 months, according to a subgroup analysis using a random-effects model. Additionally, the hepatic arterial injection favored improvements in MELD score and ALB levels. Importantly, none of the included studies indicated any severe adverse effects. Conclusion The results showed that mesenchymal stem cell was effective and safe in the treatment of liver cirrhosis, improving liver function (such as a decrease in MELD score and an increase in ALB levels) in patients with liver cirrhosis and exerting protective effects on complications of liver cirrhosis and the incidence of hepatocellular carcinoma. Although the results of the subgroup analysis were informative for the selection of mesenchymal stem cells for clinical treatment, a large number of high-quality randomized controlled trials validations are still needed.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of mesenchymal stem cell therapy in liver cirrhosis: a systematic review and meta-analysis

Lu,

Qu,

Yan

et al. 2023

Stem Cell Res Ther

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“…There were only nine studies included in this meta-analysis with high heterogenicity. Thus, further high-quality randomized control trials should be performed [75].…”

Section: Challenges and Future Prospectsmentioning

confidence: 99%

Stem Cell Therapy in Children with Traumatic Brain Injury

Lin,

Wu,

Chen

et al. 2023

IJMS

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Pediatric traumatic brain injury is a cause of major mortality, and resultant neurological sequelae areassociated with long-term morbidity. Increasing studies have revealed stem cell therapy to be a potential new treatment. However, much work is still required to clarify the mechanism of action of effective stem cell therapy, type of stem cell therapy, optimal timing of therapy initiation, combination of cocurrent medical treatment and patient selection criteria. This paper will focus on stem cell therapy in children with traumatic brain injury.

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“…Additionally, it highlights the importance of planning for the long-term care and support of individuals with cerebral palsy, ensuring they have the resources and opportunities to thrive. As we look to the future, the evolving landscape of cerebral palsy care and societal attitudes provides hope for a more inclusive and supportive world (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Cerebral Palsy: Treatment and Management

2021

Cerebral Palsy: Public Education

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Management of cerebral palsy involves a range of treatments to manage symptoms and improve quality of life. Innovative therapies and ongoing research are paving the way for new treatments and breakthroughs. Advancements in research, technology, and societal attitudes offer hope for a brighter future where individuals with cerebral palsy. Planning for the future ensures that individuals with cerebral palsy have the support and resources they need throughout their lives. This chapter focuses on various aspects of managing cerebral palsy, focusing on medical management, innovative therapies, future planning, and the optimistic outlook for individuals with cerebral palsy.

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Efficacy and safety of stem cell therapy in cerebral palsy: A systematic review and meta-analysis

Cited by 4 publications

References 55 publications

Efficacy and safety of mesenchymal stem cell therapy in liver cirrhosis: a systematic review and meta-analysis

Efficacy and safety of mesenchymal stem cell therapy in liver cirrhosis: a systematic review and meta-analysis

Stem Cell Therapy in Children with Traumatic Brain Injury

Cerebral Palsy: Treatment and Management

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