Efficacy and safety of spontaneous ventilation technique using dexmedetomidine for rigid bronchoscopic airway foreign body removal in children

Cai, Yirong; Li, Wenxian; Chen, Kaizheng

doi:10.1111/pan.12197

Cited by 26 publications

(19 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[8,9] Furthermore, dexmedetomidine can provide appropriate anesthesia depth and ideal conditions for rigid bronchoscopic airway removal of foreign bodies in children. [10] However, there are no studies to date that have compared the sedative effects and adverse reactions of different sedatives during FFB in critically ill ICU patients on mechanical ventilation. In the present study, the clinical effectiveness of dexmedetomidine and midazolam for sedation of ICU patients before FFB was compared.…”

Section: Introductionmentioning

confidence: 99%

Effect of dexmedetomidine and midazolam for flexible fiberoptic bronchoscopy in intensive care unit patients

et al. 2017

View full text Add to dashboard Cite

This study aimed to investigate the clinical effectiveness of dexmedetomidine and midazolam for sedation of intensive care unit (ICU) patients requiring flexible fiberoptic bronchoscopy (FFB).This retrospective cohort study included 148 patients from the third ICU ward of the Second Affiliated Hospital of Harbin Medical University (Harbin, China) who received simultaneous invasive mechanical ventilation and FFB between March 2012 and December 2014. Patients were divided into dexmedetomidine (n = 72) and midazolam (n = 76) groups according to sedative mode. The sedative effects, incidence of adverse events, and bronchoscopist satisfaction scores were compared between groups.During FFB, total sedation time and total time of FFB were significantly shorter in the midazolam group (P < .001, respectively), with a lower percentage of these patients requiring propofol for remedial sedation (P < .001). The incidence of FFB-related adverse events (including bronchospasm, cough, and decreased oxygen saturation) was significantly higher in dexmedetomidine group compared with midazolam group (P = .007, .014 and .008, respectively). However, the incidence of other adverse events was not significantly different between groups. In addition, bronchoscopist satisfaction scores were significantly higher in the midazolam compared with dexmedetomidine group (7.72 ± 1.65 vs 7.08 ± 1.77; P = .030).For sedation of ICU patients during FFB, combination of midazolam and dexmedetomidine demonstrated an enhanced sedative effect, lower incidence of adverse events, and higher bronchoscopist satisfaction score compared with dexmedetomidine alone, thus represents a suitable alternative sedative for FFB patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of dexmedetomidine and midazolam for flexible fiberoptic bronchoscopy in intensive care unit patients

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Bronchospasm and hypoxemia are common complications during the TFB removal procedure and could delay surgical intervention . In the present study, we found that the incidences of bronchospasm and hypoxemia in the LE and LED groups were much lower than those in the C and S groups, indicating that dexamethasone with lidocaine and epinephrine could reduce the incidences of bronchospasm and hypoxemia .…”

Section: Discussionmentioning

confidence: 46%

Effects of different bronchoalveolar lavage methods on tracheobronchial foreign body patients

Luo

Guo

et al. 2015

The Laryngoscope

View full text Add to dashboard Cite

show abstract

“…Severe morbidity and death have been associated with chloral hydrate . Similar problems have not been identified with dexmedetomidine . Intranasal dexmedetomidine appears to be a safer and more acceptable method of sedating children than oral chloral hydrate .…”

Section: Discussionmentioning

confidence: 85%

A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children

Yuen

Cheuk

et al. 2017

Anaesthesia

View full text Add to dashboard Cite

Chloral hydrate is commonly used to sedate children for painless procedures. Children may recover more quickly after sedation with dexmedetomidine, which has a shorter half-life. We randomly allocated 196 children to chloral hydrate syrup 50 mg.kg and intranasal saline spray, or placebo syrup and intranasal dexmedetomidine spray 3 μg.kg , 30 min before computerised tomography studies. More children resisted or cried after drinking chloral hydrate syrup than placebo syrup, 72 of 107 (67%) vs. 42 of 87 (48%), p = 0.009, but there was no difference after intranasal saline vs. dexmedetomidine, 49 of 107 (46%) vs. 40 of 87 (46%), p = 0.98. Sedation was satisfactory in 81 of 107 (76%) children after chloral hydrate and 64 of 87 (74%) children after dexmedetomidine, p = 0.74. Of the 173 children followed up for at least 4 h after discharge, 38 of 97 (39%) had recovered normal function after chloral hydrate and 32 of 76 (42%) after dexmedetomidine, p = 0.76. Six children vomited after chloral hydrate syrup and placebo spray vs. none after placebo syrup and dexmedetomidine spray, p = 0.03.

show abstract

Efficacy and safety of spontaneous ventilation technique using dexmedetomidine for rigid bronchoscopic airway foreign body removal in children

Abstract: Dexmedetomidine may provide appropriately deep anesthesia and ideal conditions for rigid bronchoscopic airway foreign body removal without respiratory depression or hemodynamic instability.

Cited by 26 publications

References 19 publications

Effect of dexmedetomidine and midazolam for flexible fiberoptic bronchoscopy in intensive care unit patients

Effect of dexmedetomidine and midazolam for flexible fiberoptic bronchoscopy in intensive care unit patients

Effects of different bronchoalveolar lavage methods on tracheobronchial foreign body patients

A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children

Contact Info

Product

Resources

About