Efficacy and safety of sotalol in digitalized patients with chronic atrial fibrillation

Acute conversion of persistent atrial fibrillation during dofetilide loading does not predict long-term atrial fibrillation-free survival

“…Amiodarone has comparable rates of pharmacologic [18,19], but conversion during oral amiodarone loading is less common and often delayed [20]. Sotalol does not appear to be effective in terminating persistent AF/AFl [21,22]. Overall, the high rate of pharmacologic conversion observed with dofetilide in our study increases its desirability in the treatment of persistent AF/AFl as pharmacologic conversion obviates the risks associated with anesthesia and direct current cardioversion.…”

2011 ACCF/AHA/HRS Focused Updates Incorporated Into the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation

“…Digoxin has few adverse effects after acute administration in therapeutic doses, aside from AV block and increased ventricular ectopy, but all manifestations of digitalis toxicity are dose related. 375,378,494,505,526,530,540,542 8.1.5.5.6. Disopyramide.…”

Chronic atrial fibrillation: a systematic review of medical heart rate control management

“…Better HR control at rest18 27 31 – 41 and exercise18 22 24 27 28 31 – 44 is achieved with the combination of digoxin with a β-blocker. However, the effect of this combination on exercise tolerance is inconsistent, with some studies reporting deterioration in exercise capacity,31–33 35 41 some improvement26 36 39 and most no change 22 24 27 28 31 34 37 40 42 44…”

“…However, the effect of this combination on exercise tolerance is inconsistent, with some studies reporting deterioration in exercise capacity,31–33 35 41 some improvement26 36 39 and most no change 22 24 27 28 31 34 37 40 42 44…”