Efficacy and safety of sodium phosphate tablets compared with PEG solution in colon cleansing: Two identically designed, randomized, controlled, parallel group, multicenter phase III trials

Kastenberg, David; Chasen, Richard; Choudhary, Cuckoo; Riff, Dennis; Steinberg, Stephen; Weiss, Eric G.; Wruble, Lawrence D.

doi:10.1067/mge.2001.119733

Cited by 137 publications

(99 citation statements)

References 18 publications

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“…Sodium phosphate osmotically draws plasma water into the bowel lumen to promote colonic cleansing and significant fluid and electrolyte shifts can occur [39] . Two meta analyses, comprising 71 trials (10 201 subjects) and 18 trials (2792 subjects) respectively, previously concluded that sodium phosphate-based bowel preparations resulted in a more complete and better quality of bowel preparation compared to 4-L PEG [44,45] , mainly due to the poorer compliance with the latter [46][47][48][49] . However, sodium phosphate is associated with significant fluid and electrolyte shifts due to its hyperosmotic nature and patients with renal impairment, dehydration, on angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers can develop renal failure [50][51][52] .…”

Section: Bowel Cleansing Agentsmentioning

confidence: 99%

Factors influencing quality of bowel preparation for colonoscopy

Romero

Mahadeva

2013

WJGE

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Recent technological advances in colonoscopy have led to improvements in both image enhancement and procedural performance. However, the utility of these technological advancements remain dependent on the quality of bowel preparation during colonoscopy. Poor bowel preparation has been shown to be associated with lower quality indicators of colonoscopy performance, such as reduced cecal intubation rates, increased patient discomfort and lower adenoma detection. The most popular bowel preparation regimes currently used are based on either Polyethylene glycol-electrolyte, a non-absorbable solution, or aqueous sodium phosphate, a lowvolume hyperosmotic solution. Statements from various international societies and several reviews have suggested that the efficacy of bowel preparation regimes based on both purgatives are similar, although patients' compliance with these regimes may differ somewhat. Many studies have now shown that factors other than the type of bowel preparation regime used, can influence the quality of bowel preparation among adult patients undergoing colonoscopy. These factors can be broadly categorized as either patient-related or procedure-related. Studies from both Asia and the West have identified patient-related factors such as an increased age, male gender, presence of co-morbidity and socioeconomic status of patients to be associated with poor bowel preparation among adults undergoing routine out-patient colonoscopy. Additionally, procedure-related factors such as adherence to bowel preparation instructions, timing of bowel purgative administration and appointment waiting times for colonoscopy are recognized to influence the quality of colon cleansing. Knowledge of these factors should aid clinicians in modifying bowel preparation regimes accordingly, such that the quality of colonoscopy performance and delivery of service to patients can be optimised.

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Section: Bowel Cleansing Agentsmentioning

confidence: 99%

Factors influencing quality of bowel preparation for colonoscopy

Romero

Mahadeva

2013

WJGE

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“…To the best of our knowledge, there are no published studies evaluating the safety of SPS-MC as bowel preparation before CTC and specifically its effect on renal function; following a literature search we concluded that all studies examining the metabolic safety of SPS-MC bowel preparation regimens were performed in the clinical setting of optical colonoscopy [9,11,12]. Without question, these studies are relevant to the practice of CTC.…”

Section: Introductionmentioning

confidence: 99%

Bowel preparation in CT colonography: electrolyte and renal function disturbances in the frail and elderly patient

et al. 2009

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“…However, poor compliance due to the salty taste, sulfate smell, and the large volume of solution required led to modifications of PEG preparation regimens [15,16] . NaP osmotically draws plasma water into the bowel lumen to promote colonic cleansing and is used as an alternative to PEG for bowel preparation prior to colonoscopy [5,6,17] . Oral NaP is available as an aqueous solution and in a tablet form.…”

Section: Discussionmentioning

confidence: 99%

“…onstrated equal colon cleansing with fewer side effects of the NaP regimen [17] . Recent reviews and a meta-analysis have reported that NaP preparations are generally more effective and better tolerated than are PEG formulations [18,19] .…”

Section: Times For the Completion Of The Bowel Preparationmentioning

confidence: 99%