Efficacy and safety of small intestinal submucosa in dural defect repair in a canine model

He, Shu-Kun; Guo, Jinhai; Wang, Zhu-Le; Zhang, Yi; Tu, Yun-hu; Wu, Shizhou; Huang, Fuguo; Xie, Huiqi

doi:10.1016/j.msec.2016.12.077

Cited by 28 publications

(10 citation statements)

References 67 publications

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“…According to reports, dural defects are not uncommon in neurosurgery, and they are an important factor in inducing cerebrospinal fluid leakage, intracranial infection, meningitis, encephalocele, and epilepsy. Therefore, a series of studies have been carried out for dural repair to reduce the risk of clinical treatment [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] The Study of Expanded Polytetrafluoroethylene New Material in Dural Repair

Gao

Xing

et al. 2022

Journal of Nanomaterials

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Dural defect is a common problem in neurosurgery, and the emergence of expanded polytetrafluoroethylene material provides an effective solution for the rehabilitation of artificial blood vessels, heart patches, and other fields. However, studies on the repair of expanded polytetrafluoroethylene in the dura have reported the occurrence of adverse events of cerebrospinal fluid leakage. Therefore, the task of improving expanded polytetrafluoroethylene materials cannot be delayed. In this study, a new composite dural repair material based on expanded polytetrafluoroethylene and polylactic acid-glycolic acid (expanded polytetrafluoroethylene/polylactic acid-glycolic acid) was designed and synthesized. The results of in vivo experiments confirmed that the material can fully meet the requirements of repairing the integrity of the dura mater, providing protection for the intracranial structure and rebuilding the extracellular matrix. More importantly, the new composite dural repair material can greatly reduce the incidence of cerebrospinal fluid leakage and inhibit inflammation. Therefore, the application data of this study on New Zealand rabbit species will lay an important foundation for the development of dural repair technology.

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Section: Introductionmentioning

confidence: 99%

[Retracted] The Study of Expanded Polytetrafluoroethylene New Material in Dural Repair

Gao

Xing

et al. 2022

Journal of Nanomaterials

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“…As a xenogeneic, acellular, biocompatible, biodegradable, and collagen-based scaffold, porcine SIS can enable bladder regeneration without ex vivo cell seeding before the implantation [ [40] , [41] , [42] , [43] ]. The particular biochemical components and excellent mechanical properties have conferred it with appropriate structure and microenvironment not only as a scaffold but also with specific physiological functions suitable for cell adhesion, proliferation, differentiation, and the ultimate tissue regeneration [ 35 , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] ].…”

Section: Discussionmentioning

confidence: 99%

Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model

Song

Tian

et al. 2022

Bioactive Materials

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“…Materials used for skull defect reconstruction can include autologous bone, allogenic and alloplastic materials, synthetic and organic biomaterials, or biocompatible metals and their alloys. Titanium mesh is used in human surgery for its strength, malleability, ability for easy intraoperative handling, biocompatibility and low infection rate [ 20 – 23 ]. These systems are routinely used for defect reconstruction in maxillofacial surgery for the treatment of depressed skull fractures and reconstruction of paranasal sinuses.…”

Section: Discussionmentioning

confidence: 99%

“…In the event of compromise to the dura, augmentation of the dural layer facility is indicated as previously described [ 5 ]. Dural repair materials should be biocompatible, non-toxic and may include autologous substances (pericranium, temporalis fascia and fascia lata) or biological substitute materials such as Small Intestinal Submucosa [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Treatment of calvarial defects by resorbable and non-resorbable sonic activated polymer pins and mouldable titanium mesh in two dogs: a case report

Langer¹,

Black²,

Egan³

et al. 2018

BMC Vet Res

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BackgroundTo date, calvarial defects in dogs have traditionally been addressed with different types of implants including bone allograft, polymethylmethacrylate and titanium mesh secured with conventional metallic fixation methods. This report describes the use of an absorbable and non absorbable novel polymer fixation method, Bonewelding® technology, in combination with titanium mesh for the repair of calvarial defects in two dogs. The clinical outcomes and comparative complication using resorbable and non-resorbable thermoplastic pins were compared.Case presentationThis report of two cases documents the repair of a traumatic calvarial fracture in an adult male Greyhound and a cranioplasty following frontal bone tumor resection in an adult female Cavalier King Charles Spaniel with the use of a commercially available titanium mesh secured with an innovative thermoplastic polymer screw system (Bonewelding®). The treatment combination aimed to restore cranial structure, sinus integrity and cosmetic appearance. A mouldable titanium mesh was cut to fit the bone defect of the frontal bone and secured with either resorbable or non-resorbable polymer pins using Bonewelding® technology. Gentamycin-impregnated collagen sponge was used intraoperatively to assist with sealing of the frontal sinuses. Calvarial fracture and post-operative implant positioning were advised using computed tomography. A satisfactory restoration of skull integrity and cosmetic result was achieved, and long term clinical outcome was deemed clinically adequate with good patient quality of life. Postoperative complications including rostral mesh uplift with minor associated clinical signs were encountered when resorbable pins were used. No postoperative complications were experienced in non-resorbable pins at 7 months follow-up, by contrast mesh uplift was noted 3 weeks post-procedure in the case treated using absorbable pins.ConclusionsThe report demonstrates the innovative use of sonic-activated polymer pins (Bonewelding® technology) alongside titanium mesh is a suitable alternative technique for skull defect repair in dogs. The use of Bonewelding® may offer advantages in reduction of surgical time. Further, ultrasonic pin application may be less invasive than alternative metallic fixation and potentially reduces bone trauma. Polymer systems may offer enhanced mesh-bone integration when compared to traditional metallic implants. The use of polymer pins demonstrates initial potential as a fixation method in cranioplasty. Initial findings in a single case comparison indicate a possible advantage in the use of non-absorbable over the absorbable systems to circumvent complications associated with variable polymer degradation, further long term studies with higher patient numbers are required before reliable conclusions can be made.

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Efficacy and safety of small intestinal submucosa in dural defect repair in a canine model

Cited by 28 publications

References 67 publications

[Retracted] The Study of Expanded Polytetrafluoroethylene New Material in Dural Repair

[Retracted] The Study of Expanded Polytetrafluoroethylene New Material in Dural Repair

Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model

Treatment of calvarial defects by resorbable and non-resorbable sonic activated polymer pins and mouldable titanium mesh in two dogs: a case report

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