Efficacy and Safety of Single-Session Radiofrequency Ablation in Treating Benign Thyroid Nodules: A Short-Term Prospective Cohort Study

Nguyen, Van Bang; Nguyen, Thi Xuan Thu; Nguyen, Van Vy Hau; Nguyễn, Hải Thủy; Nguyen, Dinh Toan; Le, Chi Van

doi:10.1155/2021/7556393

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…Meanwhile, nodule shrinkage was also accompanied by improvements in symptoms and cosmesis, and MWA for the treatment of BTNs in this study significantly alleviated the patients’ symptoms and cosmetic problems at the time of the last follow-up. Interestingly, although the previous literature ( 24 – 28 ) had a shorter follow-up period than our study, we found similar results: the volume reduction rapidly increased in the first 6-12 months, and the symptoms and cosmetic problems improved as the nodule volume decreased.…”

Section: Discussionsupporting

confidence: 85%

Long-term outcome of microwave ablation for benign thyroid nodules: Over 48-month follow-up study

Quan

et al. 2022

Front. Endocrinol.

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ObjectivesThe short-term effects of microwave ablation (MWA) for the treatment of benign thyroid nodules (BTNs) were satisfactory in previous studies. However, as a slowly progressing disease, the long-term efficacy of MWA for BTNs at present is not clear. Our study aim was to assess the long-term results of MWA for BTNs after a 48-month follow-up.MethodsFrom June 2015 to September 2017, 148 patients had 148 BTNs. All patients were from the China-Japan Union Hospital of Jilin University. Careful ultrasound examinations were performed 1 day, 1 month, 3 months, 6 months, 12 months, and every 6 months after MWA. The volume, volume reduction rate (VRR), recurrence rate of the ablated area and thyroid function were recorded.ResultsThe mean volumes of the 148 nodules were 15.6 ± 9.4 cm3 (range: 1.3-48.9 cm3) and 0.6 ± 0.6 cm3 (range: 0-3.5 cm3) before and 48 months after MWA, respectively, with a nodule VRR of 96.9 ± 2.5% (range: 90.4-100%). Two patients (1.35%) had recurrence after MWA. Compared with thyroid function before MWA, no significant variation was observed after MWA. Five patients experienced complications (3.38%): two patients (1.35%) had bleeding, two patients (1.35%) had ear pain and toothache during MWA, and one patient (0.68%) had hoarseness after MWA. No cases of oesophageal injury, tracheal injury, infection, skin burns, etc., were reported during or after MWA.ConclusionsBased on a long-term follow-up, MWA is an effective method for treating BTNs and is expected to be a potential first-line treatment.

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Section: Discussionsupporting

confidence: 85%

Long-term outcome of microwave ablation for benign thyroid nodules: Over 48-month follow-up study

Quan

et al. 2022

Front. Endocrinol.

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“…In this respect, Kuo et al [ 22 ], investigating 109 nodules in 93 patients, found that the mean VRR was 55.9% six months after RFA. AAs well, Nguyen et al [ 23 ], in a study on 78 benign TNs correspondingly reported the mean VRR of 41.4% and 64.7% and the TSR (VRR > 50%) of 30.8% and 84.6% at the 1- and 3-month follow-ups, respectively.…”

Section: Discussionmentioning

confidence: 72%

“…According to Lee et al [ 7 ], investigating the determinants (VRR > 50%) of the RFA success on 1619 TNs, RFA was 1.2 times more successful in men than women, but this difference was not statistically significant (OR: 1.427, p = 0.430). Nguyen et al [ 23 ], studying 78 benign TNs via multivariate regression analysis showed no statistically significant relationship between VRR and patient age (β: 0.29, p = 0.135) or gender (β: -16.09, p = 0.17). Considering the discrepancy in these findings, future studies are recommended to explore the relationship between the RFA efficacy and the level of sex hormones.…”

Section: Discussionmentioning

confidence: 99%

Effect of ultrasound parameters of benign thyroid nodules on radiofrequency ablation efficacy

Motaghed,

Chegeni,

Mosadeghkhah

et al. 2023

BMC Med Imaging

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Background and aim Ultrasound-guided radiofrequency ablation (RFA) is a minimally invasive therapy for thyroid nodules (TNs). Understanding the determinants of RFA efficacy can improve treatment and prognosis. This study aims to investigate the relationship between ultrasound parameters of benign TNs and the efficacy of RFA. Methods A pretest–posttest interventional study was conducted in 2021 on 250 randomly sampled patients with benign TNs, receiving RFA. For this purpose, the volume reduction (VR) and the VR ratio (VRR) of the nodules were measured at the 1-, 3-, 6-, and 12-month follow-up periods after the RFA completion. The technical success rate (TSR) of this procedure was then categorized into four states, including low (VRR < 25%), moderate (VRR = 25–49%), high (VRR = 50–74%), and very high (VRR ≥ 75). Ordered logistic regression (OLR) was further utilized to investigate the effect of the ultrasound parameters of TNs on the TSR. The analyses were notably performed using Stata 14.2. Results The VRR at the 1-, 3-, 6-, and 12-month follow-up periods were 38.7%, 53.6%, 59.3%, and 59.9%, respectively. The mean VR was also statistically significant at all follow-ups (p < 0.001). At the 1-, 3-, and 6-month follow-up periods, the VR of over 50% was observed in 28.2%, 52.1%, and 65.2% of the nodules, respectively. The odds ratios (ORs) of the RFA success were found to be 4.3 times higher for the nodules in the left lobe compared to the right lobe (OR: 4.31, p = 0.002), 6.3 times greater for isoechoic nodules compared to hyperechoic nodules (OR: 6.39, p < 0.001), 6.2 times higher for hyper-vascular nodules compared to hypo-vascular nodules (OR: 6.25, p = 0.005), and 2.3 times greater for mixed nodules compared to solid ones (OR: 2.37, p = 0.049). Conclusion The ultrasound parameters of TNs had a statistically significant effect on the efficacy of RFA. Small-sized, isoechoic, and hyper-vascular nodules, as well as those with mixed tissue, were observed to respond better to RFA, leading to a better prognosis in terms of VR after treatment.

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“…Thus, a few studies about the safety and efficacy of RFA for benign thyroid nodules were available and no study demonstrated its efficacy on AFTNs. 23 , 24 Therefore, our study aims to evaluate the efficacy and safety of RFA in the AFTN treatment after 2 years of follow-up and to find the factors related to treatment responses through TSH level and VRR.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Radiofrequency Ablation for the Treatment of Autonomously Functioning Thyroid Nodules: A Long-Term Prospective Study

Vu¹,

Pham²,

Nguyen³

et al. 2022

TCRM

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Objective: This study aims to evaluate the efficacy and safety of RFA in the AFTN treatment after 2 years of follow-up and to find the factors related to treatment responses through TSH level and VRR. Materials and Methods: This long-term prospective study was conducted from September 2017 to April 2021 on 17 AFTNs treated with RFA. Clinical evaluations, thyroid function tests, thyroid scintigraphy, and ultrasonography examinations were performed at 1 month, 3 months, 6 months, and 24 months after ablation. The primary endpoint was the success rate of RFA in restoring the euthyroidism stage after 24 months of follow-ups; secondary outcomes were VRR and improvements of US parameters, clinical examinations, and complications. The Spearman rank correlation test was used to determine related factors with treatment response variables. Results: At the 24 months after the procedure, symptom score, cosmetic score, vascularity grade, and nodule volume significantly decreased. The VRR reduced approximately 42.77%, 63.13%, 78.3%, and 95.65% after 1 month, 3 months, 6 months, and 24 months follow-up. All 17 patients were restored euthyroid state without taking ATDs. No major complications were collected. The last TSH level was significantly correlated with the age of patients (Spearman rho = −0.637, p = 0.008). The VRR was significantly correlated with age of patients (Spearman rho = 0.566, p = 0.018) and initial TSH (Spearman rho = 0.485, p = 0.048). Conclusion: RFA was demonstrated as a safe and effective option for AFTN treatment in long-term follow-up. It can be used as an alternative treatment with encouraging results.

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Efficacy and Safety of Single-Session Radiofrequency Ablation in Treating Benign Thyroid Nodules: A Short-Term Prospective Cohort Study

Cited by 7 publications

References 40 publications

Long-term outcome of microwave ablation for benign thyroid nodules: Over 48-month follow-up study

Long-term outcome of microwave ablation for benign thyroid nodules: Over 48-month follow-up study

Effect of ultrasound parameters of benign thyroid nodules on radiofrequency ablation efficacy

Efficacy and Safety of Radiofrequency Ablation for the Treatment of Autonomously Functioning Thyroid Nodules: A Long-Term Prospective Study

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