Efficacy and Safety of Single and Multiple Doses of Pseudoephedrine in the Treatment of Nasal Congestion associated with Common Cold

Abstract

The results demonstrate that pseudoephedrine is a safe and effective treatment for nasal congestion associated with URTI. The results from the laboratory study on day 1 demonstrate by both objective and subjective measures of nasal congestion that a single dose of 60 mg pseudoephedrine is superior to placebo treatment. Support for the decongestant efficacy of multiple doses of pseudoephedrine is provided by objective measures on day 3 and subjective measures made over three days, but not by the VAS scores on day 3.

Evidence‐based recommendations regarding the differential diagnosis and assessment of nasal congestion: using the new GRADE system

“…Correlation has been described between rhinomanometry and the subjective sensation of nasal obstruction determined by means of questionnaires and VAS scores (74,75). Some studies show corresponding results between rhinomanometry and subjective symptom scoring after inducing congestion or treating it, but no effort was made to correlate these findings with each other (76,77). Only one study stated that the findings were not an exact match, i.e.…”

Age-related changes of nasal cavity and conchae volumes and volume fractions in children: a stereological study

“…At present, there is no consensus on the best method with which to objectively assess nasal obstruction in surgery. Rhinomanometry gives a physiological measurement of nasal airflow as it measures the degree of obstruction during normal breathing by measuring nasal airflow and pressure [9]. Acoustic rhinometry gives an anatomical measure of the cross sectional area or volume of the NC during a breath hold and therefore it does not directly measure the ability of the patient to breathe through the nose.…”

Factors associated with efficacy of an ibuprofen/pseudoephedrine combination drug in pharmacy customers with common cold symptoms

“…While conservative methods such as bed rest and fluid intake can be helpful, many patients seek medical treatment to make symptoms more tolerable and/or shorten the course of symptoms. Drugs used in this regard include analgesics such as acetylsalicylic acid, ibuprofen and paracetamol (acetaminophen) and α‐adrenoceptor agonists such as phenylephrine,3 pseudoephedrine3, 4 and xylometazoline 5. As either of these drug classes is effective only against a subset of common cold symptoms, fixed‐dose combinations of two or more active ingredients are frequently used; specifically, the combination of ibuprofen plus pseudoephedrine has been shown to be more efficacious than either monotherapy 6, 7.…”