Efficacy and safety of silymarin containing antioxidant serum as an adjuvant treatment of mild‐to‐moderate acne vulgaris: A prospective, open‐label pilot study

Kim, Jemin; Lee, Yun Na; Lee, Joohee; Kim, Tae Hyun; Kim, Hyun; Choi, Ye Seul; Draelos, Zoe Diana; Kim, Jun Hyung

doi:10.1111/jocd.15439

Cited by 8 publications

(9 citation statements)

References 21 publications

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“…The severity of acne, as evaluated by GAGS, was significantly reduced after treatment with silymarin cream for one half of the face twice daily for 3 months ( p < .001). Kim and colleagues 26 investigated 22 patients with mild to moderate acne. They prescribed 0.5% silymarin-containing antioxidant serum, twice daily for 4 weeks, as an adjuvant treatment for participants while using their anti-acne medications.…”

Section: Discussionmentioning

confidence: 99%

Topical Silymarin Cream as a Novel Therapy Versus Salicylic Acid Peels in Acne Vulgaris: A Split-Face Clinical Trial

Atallah,

Badran,

Makhlouf

et al. 2023

J Cutan Med Surg

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Background Acne vulgaris is a common dermatological condition that greatly impacts patients’ self-confidence. Ongoing research is conducted to explore new treatment modalities. Silymarin owns special characteristics that qualify it as a possible treatment for acne vulgaris. Objective We evaluated the efficacy and safety of silymarin cream as a new therapeutic option against salicylic acid peels in the treatment of mild to moderate acne vulgaris. Methods A split-face, comparative, Quasi-experimental clinical trial included 30 patients with acne vulgaris. Salicylic acid 30% peels were applied as an office procedure to one half of the face every 2 weeks for 3 months. Topical silymarin 1.4% cream was prescribed as a home treatment, twice daily, to the other half of the face for 3 months. The results were evaluated using the Global Acne Grading System (GAGS), photographic evaluation, and patient self-assessment scale. The adverse effects during treatment were recorded. The sample size was calculated by Stata/IC 16.1. Results After treatment, a significant reduction of GAGS was noted on both sides of the face, with an insignificant difference between both treatments. The comparative photographic evaluation and patient self-assessment scale were also insignificant. Hyperpigmentation was recorded in 2 cases on the salicylic acid-treated side. No side effects for silymarin cream were observed. Conclusion Topical silymarin cream 1.4% showed comparable results to Salicylic acid 30% peels. It can be considered a promising safe treatment modality for mild to moderate acne vulgaris.

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Section: Discussionmentioning

confidence: 99%

Topical Silymarin Cream as a Novel Therapy Versus Salicylic Acid Peels in Acne Vulgaris: A Split-Face Clinical Trial

Atallah,

Badran,

Makhlouf

et al. 2023

J Cutan Med Surg

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“…Silymarin is the active component of milk thistle, which has antioxidant properties by scavenging free radicals 21 . It is a useful adjuvant for treating mild‐to‐moderate acne vulgaris as a silymarin‐loaded antioxidant serum 22,23 . Silymarin also prevents melanin production without affecting cell viability and decreases the expression of tyrosinase protein, which aids in preventing postinflammatory hyperpigmentation associated with acne 24 …”

Section: Discussionmentioning

confidence: 99%

“…21 It is a useful adjuvant for treating mild-to-moderate acne vulgaris as a silymarinloaded antioxidant serum. 22,23 Silymarin also prevents melanin production without affecting cell viability and decreases the expression of tyrosinase protein, which aids in preventing postinflammatory hyperpigmentation associated with acne. 24 Dietary changes might also be considered as part of the holistic treatment of acne.…”

Section: Approach To Treating Acne In the Aesthetic Patientmentioning

confidence: 99%

Treatment of acne in the aesthetic patient: A round table update

Fabi

Beleznay²,

Berson

et al. 2023

J of Cosmetic Dermatology

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BackgroundThe popularity of social media appears to be increasing the acceptance of cosmetic treatments, prompting more consumers to seek cosmetic treatments. As the estimated prevalence of acne vulgaris among adult women may be as high as 54%, acne is commonly observed among patients presenting for cosmetic treatments. Concomitant treatment of acne in the aesthetic patient population will improve overall clinical outcomes.AimsThe goal of this work was to deliver a high‐quality ethical and evidence‐based educational program to physicians and adjunctive health care providers to advance patient care.MethodsThis paper is based on a webcam presentation with roundtable discussion by several notable experts in their field.ResultsA range of topical medications, injectable products, chemical peels, and energy‐based devices are available for treating acne vulgaris. In most instances, these are compatible with rejuvenation procedures in the aesthetic patient.ConclusionThe growth of social media is raising awareness of aesthetic procedures and appears to be increasing the number of patients seeking aesthetic treatment. Educating patients about the importance of treating acne vulgaris can improve overall treatment outcomes. In most instances, the presence of acne is not a barrier to aesthetic care.

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“…Second, there are multiple confounding factors related to sebum secretion, such as weather changes, diet, and anatomical location of the measurement. 23 31 32 Third, the assessment of the participants’ satisfaction was not blinded. This could potentially introduce bias in how participants responded, as their knowledge of the treatment they received might influence their reported satisfaction.…”

Section: Discussionmentioning

confidence: 99%

Combination of Fractional Microneedling Radiofrequency and Ablative Fractional Laser versus Ablative Fractional Laser Alone for Acne and Acne Scars

Kim,

Lee,

Choi

et al. 2023

Yonsei Med J

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Purpose Fractional microneedle radiofrequency (FMR) systems are used to treat inflammatory acne and scarring. Nonetheless, few controlled studies have combined this treatment with the traditional ablative fractional laser (AFL). We aimed to assess the safety and efficacy of the combination of FMR and AFL versus AFL alone in treating acne and acne scars. Materials and Methods In this 20-week, randomized, split-face study, 23 Korean patients with facial acne and acne scars underwent FMR and AFL treatments. One half of each patient’s face was randomly assigned to receive FMR+AFL, whereas the other half received AFL alone. Treatments were administered in three consecutive sessions at 4-week intervals. This study investigated the severity of inflammatory acne, acne scars, individual lesion counts, depressed scar volumes, as well as patient and physician satisfaction. In addition, five patients underwent skin biopsy, and sebum output was measured. Results The FMR+AFL treatment demonstrated superior efficacy compared to AFL alone in terms of inflammatory acne and acne scar grading, lesion counts, and subjective satisfaction. The side effects were minimal and well-tolerated in both groups. Immunohistochemical findings from skin biopsy samples revealed that the application of FMR+AFL could induce an inhibitory effect on sebum secretion at the molecular level. Conclusion FMR combined with AFL is a well-tolerated and effective treatment modality for inflammatory acne and acne scarring.

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Efficacy and safety of silymarin containing antioxidant serum as an adjuvant treatment of mild‐to‐moderate acne vulgaris: A prospective, open‐label pilot study

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 8 publications

References 21 publications

Topical Silymarin Cream as a Novel Therapy Versus Salicylic Acid Peels in Acne Vulgaris: A Split-Face Clinical Trial

Topical Silymarin Cream as a Novel Therapy Versus Salicylic Acid Peels in Acne Vulgaris: A Split-Face Clinical Trial

Treatment of acne in the aesthetic patient: A round table update

Combination of Fractional Microneedling Radiofrequency and Ablative Fractional Laser versus Ablative Fractional Laser Alone for Acne and Acne Scars

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