Efficacy and safety of Shenkang injection in the treatment of chronic renal failure

Abstract

Background: Chronic renal failure (CRF) is the final outcome of the development of multiple kidney diseases, and there is no effective method at home and abroad. Traditional Chinese medicine is found to play a major role in the treatment of the non-replacement stage of CRF. Shenkang injection can not only nourish the kidney, but also promote blood circulation and remove blood stasis, which is suitable for the treatment of CRF. This study aims to explore the efficacy and safety of Shenkang injection for CRF and provide evidence for clinical practice. Methods: This was a prospective randomized controlled trial. One hundred four patients with CRF were randomly divided into treatment groups and control groups according to 1:1, with 52 patients in each group. The control group received basic treatment of western medicine and the treatment group was given Shenkang injection intravenously on the basis of control group. Both groups were given standard treatment for 4 weeks with concurrent follow-up for 1 month. The outcome indicators included: total efficiency, symptom scores, creatinine clearance rate, serum creatinine, blood urea nitrogen, CystatinC, liver function, blood routine, urine routine, incidence of adverse reactions, etc. Data analysis was performed using SPSS 25.0 software. Discussion: This study will evaluate the efficacy and safety of Shenkang injection for CRF, and the results of this trial will provide clinical evidence for the treatment of CRF. Trial registration: OSF Registration number: DOI 10.17605/OSF.IO/K9C5T.

Shenkang injection combined with alprostadil for chronic renal failure: A systematic review and meta-analysis

“…From the perspective of traditional Chinese medicine (TCM), CRF belongs to the categories of “edema,” “Stranguria syndrome,” and “kidney exhaustion.” CRF derives from its close association with the spleen and kidney, that is, the spleen and kidney deficiency, deficiency of both qi and yin, and the accumulation of dampness and turbidity. Shenkang injection (SKI), a kind of Chinese patent injection composed of rhubarb, salvia miltiorrhiza, astragalus and safflower, has been extensively used to treat CRF ( 12 – 14 ). On the one hand, pharmacological studies have found that SKI can decrease proteinuria by effectively alleviating anemia and renal microcirculation, thus inhibiting the pathological proliferation of kidneys, which is conducive to reducing the damage to the kidneys, promoting the repair of damaged tissues, eventually improving renal function ( 15 ).…”

Curcumenol improves renal function in 5/6 nephrectomy‐induced chronic renal failure rats via the SIRT1/NF‐κB pathway

“…At present, it is believed that the essence of the progression of CRF is glomerulosclerosis and tubulointerstitial fibrosis under the alternating action of inflammatory and fibrogenic factors; however, still there is lacking of effective targeted prevention and treatment measures in clinic. In China, TCM has been in practice for thousands of years in the treatment of CRF and has showed number of remarkable results (Lu et al, 2018; Mei, Yang, Wang, & Wang, 2021). Buxu Xiaozheng recipe is a TCM preparation developed by famous and experienced TCM doctors, which previously reported to delay renal interstitial fibrosis progression by modulating the levels of inflammatory factors and oxidative stress in chronic kidney disease patients and rat mesangial cells (Ni, Zhong, & Cai, 2016; Zhong, Wei, & Xing, 2014).…”