Efficacy and safety of Shenkang injection as adjuvant therapy in patients with diabetic nephropathy

Wang, Yanping; Li, Mingzhu; Li, Chenyun; Xu, Shaohua; Wu, Jiangfeng; Zhang, Gaochuan; Cai, Yuanyuan

doi:10.1097/md.0000000000023821

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…Despite the fact that they can achieve some effects, they have unsatisfactory outcomes [ 9 – 11 ]. The study carried out path-type health education for patients and can carry out various nursing interventions such as diet, psychology, and exercise, which can make up for the lack of conventional nursing care [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Intervention Value of Path-Type Health Education on Cognition and Renal Function of Patients with Diabetic Nephropathy

Bao¹

2021

Computational and Mathematical Methods in Medicine

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Objective. Analyze and examine the effectiveness of path-based health education for patients with diabetic nephropathy and renal function. Methods. The 162 diabetic nephropathy patients admitted to our hospital from January 2018 to January 2021 were selected, and participants were randomly assigned to groups: study group ( n = 79 ) and control group ( n = 83 ). The control group received routine nursing care, whereas the study group received path-type health education. GQOLI-74, MUIS-A scores, biochemical indicators, dietary indicators, cognition, blood glucose levels, and renal function were compared between the two groups. Results. The GQOLI-74 score of the two groups was substantially higher, while the MUIS-A score was significantly lower, although the study group changed more significantly ( P < 0.05 ) than the control group. The biochemical markers in both groups decreased significantly, but the study group changed more dramatically ( P 0.05 ) than the control group; the nutritional index values of both groups increased significantly, but the study group’s nutritional index values increased significantly ( P 0.05 ) when compared to those of the control group; the control group’s awareness of drug treatment, basic knowledge, exercise, and diet was 79.4 percent, 78.9 percent, 73.4 percent, and 91.0 percent, respectively, and the study group’s awareness of drug treatment, basic knowledge, exercise, and diet was 90.3%, 96.4%, 92.8%, and 94.0%. The study group exhibited greater awareness ( P 0.05 ) than the control group. The blood glucose indices of both groups were dramatically lowered; however, the study group’s blood glucose level declined more significantly ( P 0.05 ) than the control group. The renal function indices of both groups were considerably lower, but the study group’s renal function indexes were significantly lower ( P 0.05 ) than those of the control group. Conclusion. Pathway health education is a new nursing method that can adjust nutritional indicators, improve blood sugar and kidney function, and significantly increase patients’ awareness of the disease, which can further improve patient compliance with treatment. This nursing method has high application feasibility and high clinical value.

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Section: Discussionmentioning

confidence: 99%

Intervention Value of Path-Type Health Education on Cognition and Renal Function of Patients with Diabetic Nephropathy

Bao¹

2021

Computational and Mathematical Methods in Medicine

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“…CRF derives from its close association with the spleen and kidney, that is, the spleen and kidney deficiency, deficiency of both qi and yin, and the accumulation of dampness and turbidity. Shenkang injection (SKI), a kind of Chinese patent injection composed of rhubarb, salvia miltiorrhiza, astragalus and safflower, has been extensively used to treat CRF (12)(13)(14). On the one hand, pharmacological studies have found that SKI can decrease proteinuria by effectively alleviating anemia and renal microcirculation, thus inhibiting the pathological proliferation of kidneys, which is conducive to reducing the damage to the kidneys, promoting the repair of damaged tissues, eventually improving renal function (15).…”

Section: Introductionmentioning

confidence: 99%

Shenkang injection combined with alprostadil for chronic renal failure: A systematic review and meta-analysis

Xie

Zhang

et al. 2023

Front. Med.

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ObjectiveTo systematically evaluate the clinical efficacy and safety of Shenkang injection (SKI) combined with alprostadil in the treatment of chronic renal failure (CRF).MethodRandomized controlled trials (RCTs) of Shenkang injection combined with alprostadil in CRF treatment were investigated by retrieving a total of 7 databases including CNKI, Wanfang database, VIP, CBM, PubMed, Embase and Cochrane Library, with the search time ranging from 2012 to now. Revman 5.2 software was used for data analysis, and Cochrane bias risk tool was used to evaluate the quality of the included literature. The final results were represented by relative risk (RR), mean difference (MD) and 95% confidence interval (95% CI).ResultsA total of 20 RCTs and 1,573 patients were included in this study. Meta-analysis showed that the overall response rate (ORR) of the treatment group was superior to the control group [RR = 0.20, 95% CI (0.16, 0.25), P < 0.00001]. Compared with the control group, the treatment group achieved favorable improvement in terms of the creatinine clearance rate (Ccr) [MD = 9.48, 95% CI (8.73, 10.24), P < 0.00001], serum creatinine (Scr) [MD = −55.12, 95% CI (−63.42, −46.82), P < 0.00001], quantitative urine protein (Upro) [MD = −0.48, 95% CI (−0.53, −0.43), P < 0.00001], and blood urea nitrogen (BUN) [MD=-3.73, 95% CI (−4.08, −3.3) 7, P < 0.00001]. There was no statistical difference in the incidence of adverse reactions in each group.ConclusionCurrently, Shenkang injection combined with alprostadil has been widely used in clinical treatment of CRF due to the certain effect superior to other methods. However, its specific efficacy and safety need to be further verified through numerous large-scale clinical trials.

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“…A total of 27 RCTs (Han and Zhang, 2013;Lin, 2013;Liu, 2013;Lan, 2014;Yin, 2014;Zhou et al, 2014;He, 2015;Li and Li, 2015;Liu and Guo, 2015;Fang et al, 2016;Liu and Sun, 2016;Zhang, 2016;Zhang and Peng, 2016;Zhang, 2017a;Zhang, 2017b;Liu, 2017;Zhong, 2017;Jia, 2018;Liang, 2018;Shen, 2018;Tian et al, 2018;Ye, 2018;Lin et al, 2019;Wang et al, 2019;Xiao, 2019;Zhang and Nan, 2019;Wen et al, 2021) reported the total effective rate, including six TCMIs and seven interventions. Five TCMIs combined with PGE1 were better than PGE1 alone, including PGE1+ DCI (RR: 1.17, CI: 1.02, 1.37), PGE1+DHI (RR: 1.28, CI: 1.13, 1.46), PGE1+HQI (RR: 1.43, CI: 1.26, 1.66), PGE1+SKI (RR: 1.2, CI: 1.12, 1.3), PGE1+SMI (RR: 1.24, CI: 1.15, 1.35), and PGE1+HQI were better than PGE1+DCI (RR: 1.23, CI: 1, 1.51), which suggested advantages in improving clinical symptoms (Table 3).…”

Section: Total Effective Ratementioning

confidence: 99%

Efficacy of traditional Chinese medicine injection for diabetic kidney disease: A network meta analysis and systematic review

Long

Feng²,

Liu³

et al. 2023

Front. Pharmacol.

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Background: Diabetic kidney disease (DKD) is an important public health problem worldwide that increases the mortality of patients and incurs high medical costs. Traditional Chinese Medicine injections (TCMIs) are widely used in clinical practice. However, their efficacy is unknown owing to a lack of definitive evidence. This study conducted a network meta-analysis (NMA) to evaluate the efficacy and safety of traditional Chinese medicine injections in the treatment of DKD to provide a reference for clinical treatment.Methods: Total 7 databases had been searched, which included PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese scientific journal database (VIP), WanFang, and SinoMed. Only randomised controlled trials (RCT) had been included for analysis. The retrieval time limit was from the establishment of the database until 20 July 2022. Cochrane Risk of Bias 2.0 tool was used to evaluate the quality of the studies. Network meta-analyses, and Trial Sequential Analyses (TSA) were used to analysis the effectiveness of the included RCTs for DKD. The Stata 15.1 and R 4.0.4 were used to perform the network meta-analysis. Sensitivity analysis was used to assess the robustness of the findings. The effect of the intervention evidence are summarized on the basis of the minimum background framework.Results: NMA showed that the total effective rate of SMI, DCI, DHI, HQI, and SKI combined with alprostadil injection (PGE1) was better than PGE1 single used. Based on the surface under the cumulative ranking curve values, PGE1+DHI was the most effective for urinary albumin excretion rate and 24 h urinary albumin, PGE1+HQI was the most effective for the total response rate and β2-MG, and PGE1+SKI was the most effective for serum creatinine and blood urea nitrogen. Cluster analysis found that PGE1+HQI and PGE1+SKI could be the best treatments in terms of primary outcome measures. PGE1+SKI was found to be most effective on glomerular filtration function. PGE1+DHI was most effective for urinary protein-related indices.Conclusion: The efficacy of TCMI combined with PGE1 was higher than PGE1 single used. PGE1+HQI and PGE1+SKI were the most effective treatments. The safety of TCMI treatment should be investigated further. This study needs to be validated using large-sample, double-blind, multicentre RCTs.Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=348333], identifier [CRD42022348333].

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Efficacy and safety of Shenkang injection as adjuvant therapy in patients with diabetic nephropathy

Cited by 6 publications

References 13 publications

Intervention Value of Path-Type Health Education on Cognition and Renal Function of Patients with Diabetic Nephropathy

Intervention Value of Path-Type Health Education on Cognition and Renal Function of Patients with Diabetic Nephropathy

Shenkang injection combined with alprostadil for chronic renal failure: A systematic review and meta-analysis

Efficacy of traditional Chinese medicine injection for diabetic kidney disease: A network meta analysis and systematic review

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