Efficacy and Safety of Seprafilm for Preventing Postoperative Abdominal Adhesion: Systematic Review and Meta‐analysis

Abstract

Our systematic review and meta-analysis showed that Seprafilm could decrease abdominal adhesions after general surgery, which may benefit patients, but could not reduce postoperative intestinal obstruction. At the same time, Seprafilm did increase abdominal abscesses and anastomotic leaks.

Absorptive anti-adhesion barrier for the prevention of bowel obstruction after laparoscopic colorectal cancer surgery

“…The incidences of anastomotic leakage and abdominal abscess were increased in a large-scale randomized controlled clinical trial and meta-analysis 18,38) . However, there were no differences between the Seprafilm and non-Seprafilm groups regarding grade 3a anastomotic leakage and deep surgical site infection.…”

“…How- ever, several studies have reported negative results of Seprafilm [15][16][17][18] . Studies have described how Seprafilm was not useful in preventing BO, although it was effective in preventing adhesion 15,18) . In our study, Seprafilm was effective in preventing BO after colorectal cancer surgery.…”

“…Various products and postoperative management procedures have been used to prevent postoperative peritoneal adhesions [1][2][3][4][5][6][7][8] . The usefulness of the absorptive anti-adhesion barrier film Seprafilm [9][10][11][12][13][14] has been shown by many randomized control studies and meta-analysis, although studies with negative results do exist [15][16][17][18] . Interestingly, the reports on peritoneal adhesion or BO associated with laparoscopic surgery, the use of which has rapidly spread in recent years, are few compared with reports on open surgery 11,[19][20][21][22][23] .…”

Effect of Anti-Adhesive Barrier Use on Laryngotracheal Movement After Total Thyroidectomy: An Electrophysiological Study

“…Additionally, if two sides of the injury get in contact, fibrinogenesis and fibrinolysis are activated, and distortion of the dynamic balance between these two processes leads to adhesion formation. Seprafilm is frequently used in abdominal operations to prevent postoperative abdominal adhesions [15] and it was reported to be highly effective in a meta-analysis which analysed 8 studies and 4,203 patients. Moreover, this barrier dissolves spontaneously and does not need any further surgical procedure for removal [16].…”

On the issue of adhesions after noncomplicated thyroidectomy and application of antiadhesive medications in thyroid surgery

“…Interceed представляет собой раствор окисленной восстанов-ленной целлюлозы, а Seprafilm является комбини-рованным препаратом из гиалуроновой кислоты и карбоксиметилцеллюлозы, производимым в виде мембраны. Оба средства характеризуются нетоксич-ностью, неиммуногенностью и биосовместимостью [28][29][30][31]. O. Yigit и соавт.…”