Efficacy and safety of Salvia miltiorrhiza (Salvia miltiorrhiza Bunge) and ligustrazine injection in the adjuvant treatment of early-stage diabetic kidney disease: A systematic review and meta-analysis

Xie, Fan; Zhang, Bingcai; Dai, Shengfeng; Jin, Bong‐Soo; Zhang, Te; Fang, Dong

doi:10.1016/j.jep.2021.114346

Cited by 17 publications

(14 citation statements)

References 3 publications

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“…Xuebijing injections attenuated renal inflammation and reduced levels of IL-6 and TNF-α in a mice model [ 93 ]. One meta-analysis demonstrated that an injection of ligustrazine (a compound extracted from Chuanxiong) and Danshen (Salvia miltiorrhiza) appeared to reduce inflammation in diabetic kidney diseases [ 94 ]. In addition, previous reviews also demonstrated that elevated IL-31 is associated with UP in dialysis patients [ 95 , 96 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials

Lai

Lin

et al. 2022

Pharmaceuticals

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Uremic pruritus is a disturbing and refractory symptom in patients with advanced chronic kidney disease. Chinese herbal medicine has been reported to alleviate uremic pruritus. To investigate the effects of Chinese herbal medicine, we conducted a systematic review and meta-analysis on patients with uremic pruritus. We searched databases (prior to 3 May 2022) for randomized controlled trials on the effects of Chinese herbal medicine in treating uremic pruritus. Our meta-analysis included 3311 patients from 50 randomized controlled trials. In patients with uremic pruritus, adjunctive Chinese herbal medicine significantly improved overall effectiveness (risk ratio 1.29, 95% CI 1.23 to 1.35), quality of life, renal function, reduced pruritus score, and inflammatory biomarkers compared to control groups with hemodialysis alone or with anti-pruritic treatments. Chinese herbal medicine treatment showed a time-dependent tendency in improving the visual analog scale of dialysis patients. Compared to control groups, no significantly higher risk of adverse events in patients taking Chinese herbal medicine (risk ratio 0.60, 95% CI 0.22 to 1.63). Chinese herbal medicine appears to be effective and safe in complementing the treatment of patients with uremic pruritus.

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Section: Discussionmentioning

confidence: 99%

Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials

Lai

Lin

et al. 2022

Pharmaceuticals

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“…For instance, a meta-analysis of 25 RCTs involving 1,645 DKD patients (ligustrazine group, n = 858; control group, n = 787) revealed that ligustrazine injection reduced BUN, SCr, 24-h UP, and UAER in these patients, exhibiting certain clinical efficacy [ 105 ]. Similarly, in another meta-analysis, the combination of Salvia Root and ligustrazine also decreased the body’s inflammatory response, and it was safe and effective in early DKD treatment as an adjuvant therapy [ 106 ]. Furthermore, there was a meta-analysis in animal experiments, which showed that ligustrazine (150 mg/kg) improved the glomerular and tubular pathological changes and the indices of renal function.…”

Section: Advances In Chinese Medicine In Treatment Of Dkdmentioning

confidence: 99%

Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention

Leng

et al. 2023

Renal Failure

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Diabetic kidney disease (DKD) is a common complication of diabetes and has become the leading cause of end-stage kidney disease. The pathogenesis of DKD is complicated, and oxidative stress is considered as a core of DKD onset. High glucose can lead to increased production of reactive oxygen species (ROS) via the polyol, PKC, AGE/RAGE and hexosamine pathways, resulting in enhanced oxidative stress response. In this way, pathways such as PI3K/Akt, TGF-β1/p38-MAPK and NF-κB are activated, inducing endothelial cell apoptosis, inflammation, autophagy and fibrosis that cause histologic and functional abnormalities of the kidney and finally result in kidney injury. Presently, the treatment for DKD remains an unresolved issue. Traditional Chinese medicine (TCM) has unique advantages for DKD prevention and treatment attributed to its multi-target, multi-component, and multi-pathway characteristics. Numerous studies have proved that Chinese herbs (e.g., Golden Thread, Kudzuvine Root, Tripterygium glycosides, and Ginseng) and patent medicines (e.g., Shenshuaining Tablet, Compound Rhizoma Coptidis Capsule, and Zishen Tongluo Granule) are effective for DKD treatment. The present review described the role of oxidative stress in DKD pathogenesis and the effect of TCM intervention for DKD prevention and treatment, in an attempt to provide evidence for clinical practice.

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“…The DLI is one of the most commonly used injections in clinical practice. Unlike the traditional compatibility method, this injection combines the extract of S. miltiorrhiza with the active ingredients of Ligusticum chuanxiong (Xie et al, 2021;Ye et al, 2021). CHI is composed of the main active ingredients of these two medicinal materials.…”

Section: Tcm Prescription Injectionmentioning

confidence: 99%

Chinese herbal injection for cardio-cerebrovascular disease: Overview and challenges

et al. 2023

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Cardio-cerebrovascular diseases are the leading cause of death worldwide and there is currently no optimal treatment plan. Chinese herbal medicine injection (CHI) is obtained by combining traditional Chinese medicine (TCM) theory and modern production technology. It retains some characteristics of TCM while adding injection characteristics. CHI has played an important role in the treatment of critical diseases, especially cardio-cerebrovascular diseases, and has shown unique therapeutic advantages. TCMs that promote blood circulation and remove blood stasis, such as Salvia miltiorrhiza, Carthami flos, Panax notoginseng, and Chuanxiong rhizoma, account for a large proportion of CHIs of cardio-cerebrovascular disease. CHI is used to treat cardio-cerebrovascular diseases and has potential pharmacological activities such as anti-platelet aggregation, anti-inflammatory, anti-fibrosis, and anti-apoptosis. However, CHIs have changed the traditional method of administering TCMs, and the drugs directly enter the bloodstream, which may produce new pharmacological effects or adverse reactions. This article summarizes the clinical application, pharmacological effects, and mechanism of action of different varieties of CHIs commonly used in the treatment of cardio-cerebrovascular diseases, analyzes the causes of adverse reactions, and proposes suggestions for rational drug use and pharmaceutical care methods to provide a reference for the rational application of CHIs for cardio-cerebrovascular diseases.

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Efficacy and safety of Salvia miltiorrhiza (Salvia miltiorrhiza Bunge) and ligustrazine injection in the adjuvant treatment of early-stage diabetic kidney disease: A systematic review and meta-analysis

Cited by 17 publications

References 3 publications

Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials

Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials

Advances in oxidative stress in pathogenesis of diabetic kidney disease and efficacy of TCM intervention

Chinese herbal injection for cardio-cerebrovascular disease: Overview and challenges

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