Efficacy and safety of recombinant human growth hormone therapy in pediatric intestinal transplant recipients

Vo, Hanh D.; Elrokhsi, Salaheddin; Iverson, Angela K.; Keck, Megan

doi:10.1111/petr.14321

Cited by 1 publication

(2 citation statements)

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“…Vo et al examined the effect of recombinant human growth hormone (rhGH) on growth and allograft function in children with growth delay after ITx. 22 Seven children received rhGH at a median age of rhGH start of 9.5 years (interquartile range 4.6). Median growth velocity z score increased significantly from -0.95 at the start of treatment to 2.3 (P = 0.04) after 1 year and 1.9 (P = 0.06) after 2 years.…”

Section: Growth After Itxmentioning

confidence: 99%

“…The authors also reported that linear growth was not associated with age at ITx, episodes of rejection, renal function, or intestinal absorption. Vo et al examined the effect of recombinant human growth hormone (rhGH) on growth and allograft function in children with growth delay after ITx 22 . Seven children received rhGH at a median age of rhGH start of 9.5 years (interquartile range 4.6).…”

Section: Growth After Itxmentioning

confidence: 99%

See 1 more Smart Citation

Nutrition support considerations in pediatric small bowel transplantation

Nucci,

Crim,

King

et al. 2023

Nut in Clin Prac

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Enteral autonomy is the primary goal of intestinal failure therapy. Intestinal transplantation (ITx) is an option when enteral autonomy cannot be achieved and management complications become life‐threatening. The purpose of this review is to summarize existing medical literature related to nutrition requirements, nutrition status, and nutrition support after pediatric ITx. Achieving or maintaining adequate growth after intestinal transplant in children can be challenging because of episodes of rejection that require the use of corticosteroids, occurrences of infection that require a reduction or discontinuation of enteral or parenteral support, and fat malabsorption caused by impaired lymphatic circulation. Nutrient requirements should be assessed and modified regularly based on nutrition status, growth, ventilatory status, wound healing, and the presence of complications. Parenteral nutrition (PN) should be initiated as a continuous infusion early postoperatively. Enteral support should be initiated after evidence of graft bowel function and in the absence of clinical complications. Foods high in simple carbohydrates should be limited, as consumption may result in osmotic diarrhea. Short‐term use of a fat‐free diet followed by a low‐fat diet may reduce the risk of the development of chylous ascites. Micronutrient deficiencies and food allergies are common occurrences after pediatric ITx. Enteral/oral vitamin and mineral supplementation may be required after PN is weaned. Nutrition management of children after ITx can be challenging for all members of the healthcare team. Anthropometric parameters and micronutrient status should be monitored regularly so that interventions to promote growth and prevent or reverse nutrient deficiencies can be implemented promptly.

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Section: Growth After Itxmentioning

confidence: 99%

Section: Growth After Itxmentioning

confidence: 99%