Efficacy and Safety of Qinghao Biejia Decoction in the Treatment of Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

Li, Xiaobo; He, Zhouqing; Ru, Li; Yuan, Yueming; Zheng, Yuxin; Chen, Pengfei; Xu, Zhiyong; Wang, Qi; Shen, Jianping; Xu, Qin

doi:10.3389/fphar.2021.669269

Cited by 5 publications

(7 citation statements)

References 31 publications

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“…[21] QH and BJ are both sovereign herbs in QH-BJ decoction which is taken as a predominant prescription for SLE patients with Yin deficiency syndrome. [8] Studies have shown that the decoction can alleviate the progression of SLE by suppressing the production of Th17 cells and IL-17 in MRL/lpr mice. [22,23]…”

Section: Discussionmentioning

confidence: 99%

“…[7] TCM has been proven to be safe and effective in the treatment of SLE, especially in improving patients' symptoms and quality of life. [8] When combined with GCs, TCM shows a good synergistic effect by not only improving the treatment effect, but also reducing the dose of GCs and further promoting their withdrawal. Besides, it can prevent adverse reactions caused by GCs.…”

Section: Introductionmentioning

confidence: 99%

“…[9,10] Qinghao (QH)-Biejia (BJ) decoction, one of the classic prescriptions in ancient China, has been reported to be effective and safe in the treatment of SLE, by restoring body temperature, relieving joint pain, reducing erythema, and eliminating edema, etc. [8] QH and BJ are core components of this decoction and are always combined as a drug pair for the treatment of SLE. QH is the dried aerial part of Artemisia annua L., and BJ is the carapace of Trionyx sinensis Wiegmann.…”

Section: Introductionmentioning

confidence: 99%

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Molecular mechanism of QH-BJ drug pair in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking

Song¹,

Ji²,

Wu³

et al. 2022

Medicine

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To analyze the molecular mechanism of Qinghao-Biejia (QH-BJ) drug pair in the treatment of systemic lupus erythematosus (SLE) based on the method of network pharmacology and molecular docking technology. The components and related targets of QH-BJ drug pair, as well as SLE-related targets, were obtained. Intersection targets of QH-BJ drug pair and SLE were screened to construct the protein–protein interaction network, conduct gene ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, and establish the component-target-pathway network. The core active components and core targets of QH-BJ drug pair for the treatment of SLE were selected, and molecular docking was carried out between the ligand components and the receptor target proteins. The core active components of QH-BJ drug pair for the treatment of SLE are luteolin, quercetin, and kaempferol; the core targets are PTGS2, HSP90AA1, RELA, MAPK1, MAPK14, AKT1, JUN, TNF, TP53. The ligand components can spontaneously bind to the receptor target proteins. Besides, QH-BJ drug pair is likely to act on PI3K/Akt signal pathway, interleukin-17 signal pathway, and TNF signal pathway in the treatment of SLE. The study indicates that QH-BJ drug pair might play a role in the treatment of SLE through multi-components, multi-targets, and multi-pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular mechanism of QH-BJ drug pair in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking

Song¹,

Ji²,

Wu³

et al. 2022

Medicine

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“…Traditional Chinese medicine (TCM) has rich experience in treating SLE with a wide variety of therapies. TCM not only improves the symptoms and the quality of survival of SLE patients but also reduces the side effects of glucocorticoid drugs and is cost-effective, thus it is a common treatment for SLE in Chinese clinics [ 8 – 10 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Molecular Mechanism of Xijiao Dihuang Decoction for the Treatment of SLE Based on Network Pharmacology and Molecular Docking Analysis

Wei

Song

Gong

et al. 2022

BioMed Research International

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Objective. To elucidate the main mechanism of Xijiao Dihuang decoction (XJDHT) for the treatment of systemic lupus erythematosus (SLE). Methods. TCMSP, BATMAN-TCM, ETCM, and TCMID databases and literature search were used to screen the potential active compounds of XJDHT, and TCMSP and SwissProt databases were searched to predict the targets of the compounds. The targets of SLE were obtained from Genegards, OMIM, and DisGeNET databases, and Venn online platform was used to obtain the intersection targets of XJDHT and SLE. Afterwards, the PPI network was constructed by using the STRING database, and the core targets were identified by network topology analysis. GO and KEGG enrichment analyses were performed through R software, and molecular docking of the top three core targets and their corresponding compounds were accomplished by Autodock Vina and Pymol softwares. Results. There were 30 potential active ingredients, 289 potential targets, and 129 intersection targets screened from the above databases. Network topology analysis identified 23 core targets, such as AKT1, TNF, IL6, IL1B, and INS. GO enrichment analysis obtained 2555 terms and mainly clustering on the react to lipopolysaccharide, membrane raft, and ubiquitin-like protein ligase binding. KEGG enrichment analysis obtained 187 signaling pathways, mainly concentrating on the lipid and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, fluid shear stress, and atherosclerosis. Molecular docking verified that the active compounds of XJDHT have the strong binding activity to the core targets. Conclusion. This study preliminarily uncovers the mechanism of XJDHT acting on SLE through a “multicompound, multitarget, and multipathway” manner. XJDHT may achieve the treatment of SLE by inhibiting the proinflammatory factors, inflammatory signal cvtokines, proliferation, injury, and apoptosis processes. In summary, the present study would provide a promising theoretical basis for further clinical and experimental studies.

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“…It was one of the main prescriptions used in ancient China. In a modern pharmacological study, 1 QBD was shown to exert antipyretic, antipathogenic, and anti‐inflammatory effects and to improve immunity and sedation. It can be used in the clinical treatment of cancer fever, various inflammatory conditions, recurrent fever from multi‐drug resistant bacterial infections, rheumatic immune disease, and climacteric syndrome 2…”

Section: Introductionmentioning

confidence: 99%

Qualitative and quantitative analysis of the major components in Qinghao Biejia decoction by UPLC‐Orbitrap Fusion‐MS/MS and UPLC‐QQQ‐MS/MS and evaluation of their antibacterial activities

Cheng

Han

et al. 2022

Phytochemical Analysis

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Objective: In the present study, the chemical components of Qinghao Biejia decoction (QBD) were qualitatively and quantitatively analyzed using UPLC-Orbitrap Fusion-MS/MS and UPLC-QQQ-MS/MS techniques, followed by identification of each component's origin and evaluation of the antibacterial activity of QBD and its components.Methods: High-resolution mass spectrometry was used to obtain information on the precise molecular weight, retention time, and fragmentation ion peaks of the compounds used to identify the components of QBD and establish a method for their quantification. In vitro assays including determination of the minimal inhibitory concentration and growth curves were used to assess the antibacterial activity of QBD and its components.Results: A total of 39 components, including fatty acids, phenolic acids, amino acids, flavonoids, coumarins, terpenoids, and alkaloids, were identified by UPLC-Orbitrap Fusion-MS/MS. A high-performance analytical method was also established to quantify 12 components of QBD. The content of mangiferin was relatively high (estimated to be 814 μg/g). The results of the antibacterial assays indicated that mangiferin exhibits antibacterial effects against two strains causing respiratory tract infections. Conclusions:The present study suggests that mangiferin may serve as a natural compound which shows high antibacterial activity. The results can aid the discovery and analysis of the active antimicrobial components present in QBD and further provide a reference for quality assessment of multi-component herbal prescriptions.

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Efficacy and Safety of Qinghao Biejia Decoction in the Treatment of Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

Cited by 5 publications

References 31 publications

Molecular mechanism of QH-BJ drug pair in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking

Molecular mechanism of QH-BJ drug pair in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking

Investigating the Molecular Mechanism of Xijiao Dihuang Decoction for the Treatment of SLE Based on Network Pharmacology and Molecular Docking Analysis

Qualitative and quantitative analysis of the major components in Qinghao Biejia decoction by UPLC‐Orbitrap Fusion‐MS/MS and UPLC‐QQQ‐MS/MS and evaluation of their antibacterial activities

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